Therapeutic and diagnostic implications of Hsp90 activation
Kamal, Adeela, Boehm, Marcus F, Burrows, Francis J
Published in Trends in molecular medicine (01.06.2004)
Published in Trends in molecular medicine (01.06.2004)
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BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90
Lundgren, Karen, Zhang, Hong, Brekken, John, Huser, Nanni, Powell, Rachel E, Timple, Noel, Busch, David J, Neely, Laura, Sensintaffar, John L, Yang, Yong-ching, McKenzie, Andres, Friedman, Jessica, Scannevin, Robert, Kamal, Adeela, Hong, Kevin, Kasibhatla, Srinivas R, Boehm, Marcus F, Burrows, Francis J
Published in Molecular cancer therapeutics (01.04.2009)
Published in Molecular cancer therapeutics (01.04.2009)
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EC144 Is a Potent Inhibitor of the Heat Shock Protein 90
Shi, Jiandong, Van de Water, Ryan, Hong, Kevin, Lamer, Ryan B, Weichert, Kenneth W, Sandoval, Cristina M, Kasibhatla, Srinivas R, Boehm, Marcus F, Chao, Jianhua, Lundgren, Karen, Timple, Noelito, Lough, Rachel, Ibanez, Gerardo, Boykin, Christina, Burrows, Francis J, Kehry, Marilyn R, Yun, Theodore J, Harning, Erin K, Ambrose, Christine, Thompson, Jeffrey, Bixler, Sarah A, Dunah, Anthone, Snodgrass-Belt, Pamela, Arndt, Joseph, Enyedy, Istvan J, Li, Ping, Hong, Victor S, McKenzie, Andres, Biamonte, Marco A
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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7‘-Substituted Benzothiazolothio- and Pyridinothiazolothio-Purines as Potent Heat Shock Protein 90 Inhibitors
Zhang, Lin, Fan, Junhua, Vu, Khang, Hong, Kevin, Le Brazidec, Jean-Yves, Shi, Jiandong, Biamonte, Marco, Busch, David J, Lough, Rachel E, Grecko, Roy, Ran, Yingqing, Sensintaffar, John L, Kamal, Adeela, Lundgren, Karen, Burrows, Francis J, Mansfield, Robert, Timony, Gregg A, Ulm, Edgar H, Kasibhatla, Srinivas R, Boehm, Marcus F
Published in Journal of medicinal chemistry (24.08.2006)
Published in Journal of medicinal chemistry (24.08.2006)
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Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
Mukherjee, Ranjan, Davies, Peter J. A, Crombie, Diane L, Bischoff, Eric D, Cesario, Rosemary M, Jow, Lily, Hamann, Lawrence G, Boehm, Marcus F, Mondon, Carl E, Nadzan, Alex M, Paterniti, James R, Heyman, Richard A
Published in Nature (London) (27.03.1997)
Published in Nature (London) (27.03.1997)
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Results From the First‐in‐Human Study With Ozanimod, a Novel, Selective Sphingosine‐1‐Phosphate Receptor Modulator
Tran, Jonathan Q., Hartung, Jeffrey P., Peach, Robert J., Boehm, Marcus F., Rosen, Hugh, Smith, Heather, Brooks, Jennifer L., Timony, Gregg A., Olson, Allan D., Gujrathi, Sheila, Frohna, Paul A.
Published in Journal of clinical pharmacology (01.08.2017)
Published in Journal of clinical pharmacology (01.08.2017)
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Inhibition of mast cell degranulation by novel small molecule MRGPRX2 antagonists
Wollam, Joshua, Solomon, Michelle, Villescaz, Christiane, Lanier, Marion, Evans, Samantha, Bacon, Corinne, Freeman, David, Vasquez, Alexis, Vest, Alan, Napora, Jim, Charlot, Brittney, Cavarlez, Christine, Kim, Andrew, Dvorak, Lisa, Selfridge, Brandon, Huang, Liming, Nevarez, Andres, Dedman, Harry, Brooks, Jennifer, Frischbutter, Stefan, Metz, Martin, Serhan, Nadine, Gaudenzio, Nicolas, Timony, Gregg, Martinborough, Esther, Boehm, Marcus F., Viswanath, Veena
Published in Journal of allergy and clinical immunology (01.10.2024)
Published in Journal of allergy and clinical immunology (01.10.2024)
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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
Burrows, Francis J, Kamal, Adeela, Thao, Lia, Sensintaffar, John, Zhang, Lin, Boehm, Marcus F, Fritz, Lawrence C
Published in Nature (25.09.2003)
Published in Nature (25.09.2003)
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Journal Article
Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids
Boehm, Marcus F, Zhang, Lin, Badea, Beth Ann, White, Steven K, Mais, Dale E, Berger, Elaine, Suto, Carla M, Goldman, Mark E, Heyman, Richard A
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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Cardiac Safety of Ozanimod, a Novel Sphingosine‐1‐Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study
Tran, Jonathan Q., Hartung, Jeffrey P., Olson, Allan D., Mendzelevski, Boaz, Timony, Gregg A., Boehm, Marcus F., Peach, Robert J., Gujrathi, Sheila, Frohna, Paul A.
Published in Clinical pharmacology in drug development (01.03.2018)
Published in Clinical pharmacology in drug development (01.03.2018)
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Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids
Michellys, Pierre-Yves, Ardecky, Robert J, Chen, Jyun-Hung, D'Arrigo, Jennifer, Grese, Timothy A, Karanewsky, Donald S, Leibowitz, Mark D, Liu, Sha, Mais, Dale A, Mapes, Christopher M, Montrose-Rafizadeh, Chahrzad, Ogilvie, Katheen M, Reifel-Miller, Anne, Rungta, Deepa, Thompson, Anthony W, Tyhonas, John S, Boehm, Marcus F
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
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Design, synthesis and structure–activity relationship of novel RXR-selective modulators
Michellys, Pierre-Yves, D'Arrigo, Jennifer, Grese, Timothy A., Karanewsky, Donald S., Leibowitz, Mark D., Mais, Dale A., Mapes, Christopher M., Reifel-Miller, Anne, Rungta, Deepa, Boehm, Marcus F.
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
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Rationally Designed High-Affinity 2-Amino-6-halopurine Heat Shock Protein 90 Inhibitors That Exhibit Potent Antitumor Activity
Kasibhatla, Srinivas R, Hong, Kevin, Biamonte, Marco A, Busch, David J, Karjian, Patricia L, Sensintaffar, John L, Kamal, Adeela, Lough, Rachel E, Brekken, John, Lundgren, Karen, Grecko, Roy, Timony, Gregg A, Ran, Yingqing, Mansfield, Robert, Fritz, Lawrence C, Ulm, Edgar, Burrows, Francis J, Boehm, Marcus F
Published in Journal of medicinal chemistry (14.06.2007)
Published in Journal of medicinal chemistry (14.06.2007)
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Cloning and expression of goldfish opsin sequences
Johnson, Randy L, Grant, Kathryn B, Zankel, Todd C, Boehm, Marcus F, Merbs, Shannath L, Nathans, Jeremy, Nakanishi, Koji
Published in Biochemistry (Easton) (12.01.1993)
Published in Biochemistry (Easton) (12.01.1993)
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Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90
Biamonte, Marco A, Shi, Jiandong, Hong, Kevin, Hurst, David C, Zhang, Lin, Fan, Junhua, Busch, David J, Karjian, Patricia L, Maldonado, Angelica A, Sensintaffar, John L, Yang, Yong-Ching, Kamal, Adeela, Lough, Rachel E, Lundgren, Karen, Burrows, Francis J, Timony, Gregg A, Boehm, Marcus F, Kasibhatla, Srinivas R
Published in Journal of medicinal chemistry (26.01.2006)
Published in Journal of medicinal chemistry (26.01.2006)
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Journal Article
Synthesis and Biological Evaluation of a New Class of Geldanamycin Derivatives as Potent Inhibitors of Hsp90
Le Brazidec, Jean-Yves, Kamal, Adeela, Busch, David, Thao, Lia, Zhang, Lin, Timony, Gregg, Grecko, Roy, Trent, Katy, Lough, Rachel, Salazar, Tim, Khan, Samina, Burrows, Francis, Boehm, Marcus F
Published in Journal of medicinal chemistry (15.07.2004)
Published in Journal of medicinal chemistry (15.07.2004)
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Journal Article
Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes
Leibowitz, Mark D, Ardecky, Robert J, Boehm, Marcus F, Broderick, Carol L, Carfagna, Mark A, Crombie, Diane L, D’Arrigo, Jennifer, Etgen, Garrett J, Faul, Margaret M, Grese, Timothy A, Havel, Henry, Hein, Nancy I, Heyman, Richard A, Jolley, Diane, Klausing, Kay, Liu, Sha, Mais, Dale E, Mapes, Christopher M, Marschke, Keith B, Michellys, Pierre-Yves, Montrose-Rafizadeh, Chahrzad, Ogilvie, Kathleen M, Pascual, Bernadette, Rungta, Deepa, Tyhonas, John S, Urcan, Mary S, Wardlow, Marilyn, Yumibe, Nathan, Reifel-Miller, Anne
Published in Endocrinology (Philadelphia) (01.02.2006)
Published in Endocrinology (Philadelphia) (01.02.2006)
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Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells
Boehm, Marcus F, Zhang, Lin, Zhi, Lin, McClurg, Michael R, Berger, Elain, Wagoner, Murriel, Mais, Dale E, Suto, Carla M, Davies, Peter J. A, Heyman, Richard A, Nadzan, Alex M
Published in Journal of medicinal chemistry (01.08.1995)
Published in Journal of medicinal chemistry (01.08.1995)
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