Promotion of Sleep by Suvorexant-A Novel Dual Orexin Receptor Antagonist
Winrow, Christopher J., Gotter, Anthony L., Cox, Christopher D., Doran, Scott M., Tannenbaum, Pamela L., Breslin, Michael J., Garson, Susan L., Fox, Steven V., Harrell, Charles M., Stevens, Joanne, Reiss, Duane R., Cui, Donghui, Coleman, Paul J., Renger, John J.
Published in Journal of neurogenetics (01.03.2011)
Published in Journal of neurogenetics (01.03.2011)
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Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
Cox, Christopher D., Breslin, Michael J., Mariano, Brenda J., Coleman, Paul J., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Huber, Hans E., Kohl, Nancy E., Torrent, Maricel, Yan, Youwei, Kuo, Laurence C., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
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Nonpeptide alpha(v)beta(3) antagonists. 8. In vitro and in vivo evaluation of a potent alpha(v)beta(3) antagonist for the prevention and treatment of osteoporosis
Hutchinson, JH, Hatczenko, W, Brashear, KM, Breslin, MJ, Coleman, PJ, Duong, LT, Fernandez-Metzler, C, Gentile, MA, Fisher, JE, Hartman, GD, Huff, Kimmel, DB, Leu, CT, Meissner, RS, Merkle, K, Nagy, R, Pennypacker, B, Perkins, JJ, Prueksaritanont, T, Rodan, GA, Varga, SL, Wesolowski, GA, Zartman, AE, Rodan, SB, Duggan, ME
Published in Journal of medicinal chemistry (23.10.2003)
Published in Journal of medicinal chemistry (23.10.2003)
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Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP
COX, Christopher D, TORRENT, Maricel, LOBELL, Robert B, WEIKANG TAO, SOUTH, Vicki J, KOHL, Nancy E, YOUWEI YAN, KUO, Lawrence C, PRUEKSARITANONT, Thomayant, SLAUGHTER, Donald E, CHUNZE LI, MAHAN, Elizabeth, BRESLIN, Michael J, BING LU, HARTMAN, George D, MARIANO, Brenda J, WHITMAN, David B, COLEMAN, Paul J, BUSER, Carolyn A, WALSH, Eileen S, HAMILTON, Kelly, SCHABER, Michael D
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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Non-peptide glycoprotein IIb/IIIa antagonists .2. Design and in vivo evaluation of 3,4-dihydro-1(1H)-isoquinolinone-based antagonists and ethyl ester prodrugs
Hutchinson, JH, Cook, JJ, Brashear, KM, Breslin, MJ, Glass, JD, Gould, RJ, Halczenko, W, Holahan, MA, Lynch, RJ, Sitko, GR, Stranieri, MT, Hartman, GD
Published in Journal of medicinal chemistry (08.11.1996)
Published in Journal of medicinal chemistry (08.11.1996)
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N-Arylpiperazinone Inhibitors of Farnesyltransferase: Discovery and Biological Activity
Williams, Theresa M, Bergman, Jeffrey M, Brashear, Karen, Breslin, Michael J, Dinsmore, Christopher J, Hutchinson, John H, MacTough, Suzanne C, Stump, Craig A, Wei, Donna D, Zartman, C. Blair, Bogusky, Michael J, Culberson, J. Christopher, Buser-Doepner, Carolyn, Davide, Joseph, Greenberg, Ian B, Hamilton, Kelly A, Koblan, Kenneth S, Kohl, Nancy E, Liu, Dongming, Lobell, Robert B, Mosser, Scott D, O'Neill, Timothy J, Rands, Elaine, Schaber, Michael D, Wilson, Francine, Senderak, Edith, Motzel, Sherri L, Gibbs, Jackson B, Graham, Samuel L, Heimbrook, David C, Hartman, George D, Oliff, Allen I, Huff, Joel R
Published in Journal of medicinal chemistry (23.09.1999)
Published in Journal of medicinal chemistry (23.09.1999)
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PSEUDOPEPTIDE INHIBITORS OF RAS FARNESYL-PROTEIN TRANSFERASE
GRAHAM, SL, DESOLMS, SJ, GIULIANI, EA, KOHL, NE, MOSSER, SD, OLIFF, AI, POMPLIANO, DL, RANDS, E, BRESLIN, MJ, DEANA, AA, GARSKY, VM, SCHOLZ, TH, GIBBS, JB, SMITH, RL
Published in Journal of medicinal chemistry (18.03.1994)
Published in Journal of medicinal chemistry (18.03.1994)
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Non-Peptide α vβ 3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel β-Amino acids as aspartic acid replacements
Coleman, Paul J, Brashear, Karen M, Hunt, Cecilia A, Hoffman, William F, Hutchinson, John H, Breslin, Michael J, McVean, Carol A, Askew, Ben C, Hartman, George D, Rodan, Sevgi B, Rodan, Gideon A, Leu, Chih-Tai, Prueksaritanont, Thomayant, Fernandez-Metzler, Carmen, Ma, Bennett, Libby, Laura A, Merkle, Kara M, Stump, Gary L, Wallace, Audrey A, Lynch, Joseph J, Lynch, Robert, Duggan, Mark E
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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Discovery and initial structure–Activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists
Barrow, James C, Nantermet, Philippe G, Selnick, Harold G, Glass, Kristen L, Ngo, Phung L, Young, Mary Beth, Pellicore, Janetta M, Breslin, Michael J, Hutchinson, John H, Freidinger, Roger M, Condra, Cindra, Karczewski, Jerzy, Bednar, Rodney A, Gaul, Stanley L, Stern, Andrew, Gould, Robert, Connolly, Thomas M
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
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Potent, non-thiol inhibitors of farnesyltransferase
Breslin, Michael J., deSolms, S.Jane, Giuliani, Elizabeth A., Stokker, Gerald E., Graham, Samuel L., Pompliano, David L., Mosser, Scott D., Hamilton, Kelly A., Hutchinson, John H.
Published in Bioorganic & medicinal chemistry letters (01.12.1998)
Published in Bioorganic & medicinal chemistry letters (01.12.1998)
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In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist : An approach for the selection of a prodrug candidate
PRUEKSARITANONT, T, GORHAM, L. M, BRESLIN, M. J, HUTCHINSON, J. H, HARTMAN, G. D, VYAS, K. P, BAILLIE, T. A
Published in Drug metabolism and disposition (01.08.1997)
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Published in Drug metabolism and disposition (01.08.1997)
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Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors
Egbertson, Melissa S, Bednar, Bohumil, Askew, Ben C, Bednar, Rodney A, Brashear, Karen, Breslin, Michael J, Duggan, Mark E, Fisher, Thorsten E, Halczenko, Wasyl, Hutchinson, John H, Ihle, Nathan, Prugh, John D, Wai, John S, Gould, Robert J, Hartman, George D
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
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