KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
Alam, Hunain, Tang, Ming, Maitituoheti, Mayinuer, Dhar, Shilpa S., Kumar, Manish, Han, Chae Young, Ambati, Chandrashekar R., Amin, Samir B., Gu, Bingnan, Chen, Tsai-Yu, Lin, Yu-Hsi, Chen, Jichao, Muller, Florian L., Putluri, Nagireddy, Flores, Elsa R., DeMayo, Francesco J., Baseler, Laura, Rai, Kunal, Lee, Min Gyu
Published in Cancer cell (13.04.2020)
Published in Cancer cell (13.04.2020)
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Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer
Lissanu Deribe, Yonathan, Sun, Yuting, Terranova, Christopher, Khan, Fatima, Martinez-Ledesma, Juan, Gay, Jason, Gao, Guang, Mullinax, Robert A., Khor, Tin, Feng, Ningping, Lin, Yu-Hsi, Wu, Chia-Chin, Reyes, Claudia, Peng, Qian, Robinson, Frederick, Inoue, Akira, Kochat, Veena, Liu, Chang-Gong, Asara, John M., Moran, Cesar, Muller, Florian, Wang, Jing, Fang, Bingliang, Papadimitrakopoulou, Vali, Wistuba, Ignacio I., Rai, Kunal, Marszalek, Joseph, Futreal, P. Andrew
Published in Nature medicine (01.07.2018)
Published in Nature medicine (01.07.2018)
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Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine
Barekatain, Yasaman, Ackroyd, Jeffrey J., Yan, Victoria C., Khadka, Sunada, Wang, Lin, Chen, Ko-Chien, Poral, Anton H., Tran, Theresa, Georgiou, Dimitra K., Arthur, Kenisha, Lin, Yu-Hsi, Satani, Nikunj, Ballato, Elliot S., Behr, Eliot I., deCarvalho, Ana C., Verhaak, Roel G. W., de Groot, John, Huse, Jason T., Asara, John M., Kalluri, Raghu, Muller, Florian L.
Published in Nature communications (09.07.2021)
Published in Nature communications (09.07.2021)
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ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase
Satani, Nikunj, Lin, Yu-Hsi, Hammoudi, Naima, Raghavan, Sudhir, Georgiou, Dimitra K, Muller, Florian L
Published in PloS one (28.12.2016)
Published in PloS one (28.12.2016)
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Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma
Maitituoheti, Mayinuer, Keung, Emily Z., Tang, Ming, Yan, Liang, Alam, Hunain, Han, Guangchun, Singh, Anand K., Raman, Ayush T., Terranova, Christopher, Sarkar, Sharmistha, Orouji, Elias, Amin, Samir B., Sharma, Sneha, Williams, Maura, Samant, Neha S., Dhamdhere, Mayura, Zheng, Norman, Shah, Tara, Shah, Amiksha, Axelrad, Jacob B., Anvar, Nazanin E., Lin, Yu-Hsi, Jiang, Shan, Chang, Edward Q., Ingram, Davis R., Wang, Wei-Lien, Lazar, Alexander, Lee, Min Gyu, Muller, Florian, Wang, Linghua, Ying, Haoqiang, Rai, Kunal
Published in Cell reports (Cambridge) (20.10.2020)
Published in Cell reports (Cambridge) (20.10.2020)
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The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues
Pisaneschi, Federica, Yu-Hsi, Lin, Leonard, Paul G, Satani, Nikunj, Yan, Victoria C, Hammoudi, Naima, Raghavan, Sudhir, Link, Todd M, Georgiou, Dimitra K, Czako, Barbara, Muller, Florian L
Published in Molecules (Basel, Switzerland) (09.07.2019)
Published in Molecules (Basel, Switzerland) (09.07.2019)
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An enolase inhibitor for the targeted treatment of ENO1-deleted cancers
Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Yan, Victoria C, Barekatain, Yasaman, Khadka, Sunada, Ackroyd, Jeffrey J, Georgiou, Dimitra K, Pham, Cong-Dat, Arthur, Kenisha, Maxwell, David, Peng, Zhenghong, Leonard, Paul G, Czako, Barbara, Pisaneschi, Federica, Mandal, Pijus, Sun, Yuting, Zielinski, Rafal, Pando, Susana Castro, Wang, Xiaobo, Tran, Theresa, Xu, Quanyu, Wu, Qi, Jiang, Yongying, Kang, Zhijun, Asara, John M, Priebe, Waldemar, Bornmann, William, Marszalek, Joseph R, DePinho, Ronald A, Muller, Florian L
Published in Nature metabolism (01.12.2020)
Published in Nature metabolism (01.12.2020)
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Journal Article
Targeting Host Glycolysis as a Strategy for Antimalarial Development
Jezewski, Andrew J, Lin, Yu-Hsi, Reisz, Julie A, Culp-Hill, Rachel, Barekatain, Yasaman, Yan, Victoria C, D'Alessandro, Angelo, Muller, Florian L, Odom John, Audrey R
Published in Frontiers in cellular and infection microbiology (16.09.2021)
Published in Frontiers in cellular and infection microbiology (16.09.2021)
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Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma
Khadka, Sunada, Arthur, Kenisha, Barekatain, Yasaman, Behr, Eliot, Washington, Mykia, Ackroyd, Jeffrey, Crowley, Kaitlyn, Suriyamongkol, Pornpa, Lin, Yu-Hsi, Pham, Cong-Dat, Zielinski, Rafal, Trujillo, Marissa, Galligan, James, Georgiou, Dimitra K, Asara, John, Muller, Florian
Published in Cancer & metabolism (25.06.2021)
Published in Cancer & metabolism (25.06.2021)
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Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment
Wang, Qianghu, Hu, Baoli, Hu, Xin, Kim, Hoon, Squatrito, Massimo, Scarpace, Lisa, deCarvalho, Ana C., Lyu, Sali, Li, Pengping, Li, Yan, Barthel, Floris, Cho, Hee Jin, Lin, Yu-Hsi, Satani, Nikunj, Martinez-Ledesma, Emmanuel, Zheng, Siyuan, Chang, Edward, Sauvé, Charles-Etienne Gabriel, Olar, Adriana, Lan, Zheng D., Finocchiaro, Gaetano, Phillips, Joanna J., Berger, Mitchel S., Gabrusiewicz, Konrad R., Wang, Guocan, Eskilsson, Eskil, Hu, Jian, Mikkelsen, Tom, DePinho, Ronald A., Muller, Florian, Heimberger, Amy B., Sulman, Erik P., Nam, Do-Hyun, Verhaak, Roel G.W.
Published in Cancer cell (10.07.2017)
Published in Cancer cell (10.07.2017)
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An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Molina, Jennifer R., Sun, Yuting, Protopopova, Marina, Gera, Sonal, Bandi, Madhavi, Bristow, Christopher, McAfoos, Timothy, Morlacchi, Pietro, Ackroyd, Jeffrey, Agip, Ahmed-Noor A., Al-Atrash, Gheath, Asara, John, Bardenhagen, Jennifer, Carrillo, Caroline C., Carroll, Christopher, Chang, Edward, Ciurea, Stefan, Cross, Jason B., Czako, Barbara, Deem, Angela, Daver, Naval, de Groot, John Frederick, Dong, Jian-Wen, Feng, Ningping, Gao, Guang, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Giuliani, Virginia, Han, Jing, Han, Lina, Henry, Verlene K., Hirst, Judy, Huang, Sha, Jiang, Yongying, Kang, Zhijun, Khor, Tin, Konoplev, Sergej, Lin, Yu-Hsi, Liu, Gang, Lodi, Alessia, Lofton, Timothy, Ma, Helen, Mahendra, Mikhila, Matre, Polina, Mullinax, Robert, Peoples, Michael, Petrocchi, Alessia, Rodriguez-Canale, Jaime, Serreli, Riccardo, Shi, Thomas, Smith, Melinda, Tabe, Yoko, Theroff, Jay, Tiziani, Stefano, Xu, Quanyun, Zhang, Qi, Muller, Florian, DePinho, Ronald A., Toniatti, Carlo, Draetta, Giulio F., Heffernan, Timothy P., Konopleva, Marina, Jones, Philip, Di Francesco, M. Emilia, Marszalek, Joseph R.
Published in Nature medicine (01.07.2018)
Published in Nature medicine (01.07.2018)
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SF2312 is a natural phosphonate inhibitor of enolase
Leonard, Paul G, Satani, Nikunj, Maxwell, David, Lin, Yu-Hsi, Hammoudi, Naima, Peng, Zhenghong, Pisaneschi, Federica, Link, Todd M, Lee, Gilbert R, Sun, Duoli, Prasad, Basvoju A Bhanu, Di Francesco, Maria Emilia, Czako, Barbara, Asara, John M, Wang, Y Alan, Bornmann, William, DePinho, Ronald A, Muller, Florian L
Published in Nature chemical biology (01.12.2016)
Published in Nature chemical biology (01.12.2016)
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A Novel B7-H6-Targeted IgG-Like T Cell-Engaging Antibody for the Treatment of Gastrointestinal Tumors
Zhang, Wei, Auguste, Aurélie, Liao, Xiaoyun, Walterskirchen, Christian, Bauer, Kathrin, Lin, Yu-Hsi, Yang, Ling, Sayedian, Farzaneh, Fabits, Markus, Bergmann, Michael, Binder, Carina, Corrales, Leticia, Vogt, Anne B, Hudson, Lindsey J, Barnes, Martin P, Bisht, Arnima, Giragossian, Craig, Voynov, Vladimir, Adam, Paul J, Hipp, Susanne
Published in Clinical cancer research (01.12.2022)
Published in Clinical cancer research (01.12.2022)
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Prodrugs of a 1‑Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers
Yan, Victoria C., Pham, Cong-Dat, Ballato, Elliot S., Yang, Kristine L., Arthur, Kenisha, Khadka, Sunada, Barekatain, Yasaman, Shrestha, Prakriti, Tran, Theresa, Poral, Anton H., Washington, Mykia, Raghavan, Sudhir, Czako, Barbara, Pisaneschi, Federica, Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Ackroyd, Jeffrey J., Georgiou, Dimitra K., Millward, Steven W., Muller, Florian L.
Published in Journal of medicinal chemistry (27.10.2022)
Published in Journal of medicinal chemistry (27.10.2022)
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Combination of JAK2 and HSP90 inhibitors: an effective therapeutic option in drug-resistant chronic myelogenous leukemia
Chakraborty, Sandip N, Leng, Xiaohong, Perazzona, Bastianella, Sun, Xiaoping, Lin, Yu-Hsi, Arlinghaus, Ralph B
Published in Genes & cancer (01.05.2016)
Published in Genes & cancer (01.05.2016)
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Comparative Pharmacology of a Bis-Pivaloyloxymethyl Phosphonate Prodrug Inhibitor of Enolase after Oral and Parenteral Administration
Yan, Victoria C., Barekatain, Yasaman, Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Arthur, Kenisha, Georgiou, Dimitra K., Jiang, Yongying, Sun, Yuting, Marszalek, Joseph R., Millward, Steven W., Muller, Florian L.
Published in ACS pharmacology & translational science (10.02.2023)
Published in ACS pharmacology & translational science (10.02.2023)
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Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment
Wang, Qianghu, Hu, Baoli, Hu, Xin, Kim, Hoon, Squatrito, Massimo, Scarpace, Lisa, deCarvalho, Ana C., Lyu, Sali, Li, Pengping, Li, Yan, Barthel, Floris, Cho, Hee Jin, Lin, Yu-Hsi, Satani, Nikunj, Martinez-Ledesma, Emmanuel, Zheng, Siyuan, Chang, Edward, Gabriel Sauvé, Charles-Etienne, Olar, Adriana, Lan, Zheng D., Finocchiaro, Gaetano, Phillips, Joanna J., Berger, Mitchel S., Gabrusiewicz, Konrad R., Wang, Guocan, Eskilsson, Eskil, Hu, Jian, Mikkelsen, Tom, DePinho, Ronald A., Muller, Florian, Heimberger, Amy B., Sulman, Erik P., Nam, Do-Hyun, Verhaak, Roel G.W.
Published in Cancer cell (08.01.2018)
Published in Cancer cell (08.01.2018)
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TAMI-62. ANGIOGENESIS INHIBITORS STRONGLY SYNERGIZE WITH THERAPEUTICS TARGETING TUMOR METABOLISM
Khadka, Sunada, Lin, Yu-Hsi, Ackroyd, Jeffrey, Arthur, Kenisha, Barekatain, Yasaman, Poral, Anton, Tran, Theresa, Georgiou, Dimitra, de Groot, John, Huse, Jason, Asara, John, Muller, Florian
Published in Neuro-oncology (Charlottesville, Va.) (09.11.2020)
Published in Neuro-oncology (Charlottesville, Va.) (09.11.2020)
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