Optimization of Novel Antagonists to the Neurokinin‑3 Receptor for the Treatment of Sex-Hormone Disorders (Part II)
Hoveyda, Hamid R, Fraser, Graeme L, Dutheuil, Guillaume, El Bousmaqui, Mohamed, Korac, Julien, Lenoir, François, Lapin, Alexey, Noël, Sophie
Published in ACS medicinal chemistry letters (09.07.2015)
Published in ACS medicinal chemistry letters (09.07.2015)
Get full text
Journal Article
Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Roy, Marie-Odile, El Bousmaqui, Mohamed, Batt, Frederic, Fraser, Graeme Lovat, Hoveyda, Hamid R, Dutheuil, Guillaume
Year of Publication 09.03.2021
Get full text
Year of Publication 09.03.2021
Patent
NOVEL CHIRAL N-ACYL-5,6,7(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
Roy, Marie-Odile, Batt, Frederic, Fraser, Graeme Lovat, Hoveyda, Hamid R, Dutheuil, Guillaume, Bousmaqui, Mohamed El
Year of Publication 10.09.2020
Get full text
Year of Publication 10.09.2020
Patent
Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Roy, Marie-Odile, Batt, Frederic, Fraser, Graeme Lovat, Hoveyda, Hamid R, Dutheuil, Guillaume, Bousmaqui, Mohamed El
Year of Publication 16.06.2020
Get full text
Year of Publication 16.06.2020
Patent
NOVEL CHIRAL N-ACYL-5,6,7(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
Roy, Marie-Odile, Batt, Frederic, Fraser, Graeme Lovat, Hoveyda, Hamid R, Dutheuil, Guillaume, Bousmaqui, Mohamed El
Year of Publication 24.01.2019
Get full text
Year of Publication 24.01.2019
Patent
Novel chiral N-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Roy, Marie-Odile, Fraser, Graeme, Hoveyda, Hamid, El Bousmaqui, Mohamed, Batt, Frederic, Dutheuil, Guillaume
Year of Publication 19.07.2018
Get full text
Year of Publication 19.07.2018
Patent
Novel chiral N-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Roy, Marie-Odile, Fraser, Graeme, Hoveyda, Hamid, El Bousmaqui, Mohamed, Batt, Frederic, Dutheuil, Guillaume
Year of Publication 06.07.2017
Get full text
Year of Publication 06.07.2017
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
Hoveyda Hamid, Fraser Graeme, Bousmaqui Mohamed El, Batt Frédéric, Dutheuil Guillaume, Roy Marie-Odile
Year of Publication 02.02.2017
Get full text
Year of Publication 02.02.2017
Patent
Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Batt Frederic, El Bousmaqui Mohamed, Fraser Graeme L, Dutheuil Guillaume, Hoveyda Hamid R, Roy Marie-Odile
Year of Publication 25.10.2016
Get full text
Year of Publication 25.10.2016
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
Roy, Marie-Odile, Fraser, Graeme, El Bousmaqui, Mohamed, Dutheuil, Guillaume, Hoveyeda, Hamid, Batt, Frédéric
Year of Publication 15.07.2016
Get full text
Year of Publication 15.07.2016
Patent
CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
HOVEYDA, HAMID, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME, BATT, FREDERIC
Year of Publication 11.06.2019
Get full text
Year of Publication 11.06.2019
Patent
N-acil-5,6,7, (8-substituído) - tetraidro-[1,2,4] triazolo [4,3 -a] pirazinas quirais inovadoras como antagonistas de receptor de nk-3 seletivos, composição farmacêutica, métodos para usar em distúrbios mediados por receptor de nk-3 e síntese quiral dos mesmos
DUTHEUIL GUILLAUME, BATT FRÉDÉRIC, ROY MARIE-ODILE, FRASER GRAEME, MOHAMED EL BOUSMAQUI, HOVEYDA HAMID
Year of Publication 17.05.2022
Get full text
Year of Publication 17.05.2022
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS
DUTHEUIL, Guillaume, EL BOUSMAQUI, Mohamed, ROY, Marie-Odile, HOVEYEDA, Hamid, FRASER, Graeme, BATT, Frederic
Year of Publication 30.01.2017
Get full text
Year of Publication 30.01.2017
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-(1,2,4)TRIAZOLO(4,3-A)PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS
ROY Marie-Odile, FRASER Graeme, EL BOUSMAQUI Mohamed, BATT Frederic, HOVEYEDA Hamid, DUTHEUIL Guillaume
Year of Publication 31.08.2016
Get full text
Year of Publication 31.08.2016
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS
BATT, FRÉDÉRIC, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME, HOVEYEDA, HAMID
Year of Publication 31.08.2016
Get full text
Year of Publication 31.08.2016
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS
BATT, FRÉDÉRIC, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME, HOVEYEDA, HAMID
Year of Publication 24.08.2016
Get full text
Year of Publication 24.08.2016
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
BATT, FRÉDÉRIC, HOVEYDA, HAMID, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME
Year of Publication 08.06.2016
Get full text
Year of Publication 08.06.2016
Patent
HIDTIL UKENDTE CHIRALE N-ACYL-5,6,7,(8-SUBSTITUERET)-TETRAHYDRO-[1,2,4]TRIAZOL[4,3-A]PYRAZINER SOM SELEKTIVE NK-3-RECEPTORANTAGONISTER, FARMACEUTISK SAMMENSÆTNING OG FREMGANGSMÅDER TIL ANVENDELSE VED NK-3-RECEPTORMEDIEREDE SYGDOMME
BATT, FRÉDÉRIC, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, FRASER, GRAEME, DUTHEUIL, GUILLAUME, HOVEYEDA, HAMID
Year of Publication 25.04.2016
Get full text
Year of Publication 25.04.2016
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS
BATT, FRÉDÉRIC, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME, HOVEYEDA, HAMID
Year of Publication 06.04.2016
Get full text
Year of Publication 06.04.2016
Patent
Novel chiral n-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor mediated disorders and chiral synthesis thereof
DUTHEUIL GUILLAUME, ROY MARIE-ODILE, FRASER GRAEME, EL BOUSMAQUI MOHAMED, BATT FREDERIC, HOVEYDA HAMID
Year of Publication 23.12.2015
Get full text
Year of Publication 23.12.2015
Patent