Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides
Lau, Yu Heng, Wu, Yuteng, Rossmann, Maxim, Tan, Ban Xiong, de Andrade, Peterson, Tan, Yaw Sing, Verma, Chandra, McKenzie, Grahame J., Venkitaraman, Ashok R., Hyvönen, Marko, Spring, David R.
Published in Angewandte Chemie (14.12.2015)
Published in Angewandte Chemie (14.12.2015)
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Journal Article
Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer
Wiedmann, Mareike M., Tan, Yaw Sing, Wu, Yuteng, Aibara, Shintaro, Xu, Wenshu, Sore, Hannah F., Verma, Chandra S., Itzhaki, Laura, Stewart, Murray, Brenton, James D., Spring, David R.
Published in Angewandte Chemie International Edition (09.01.2017)
Published in Angewandte Chemie International Edition (09.01.2017)
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Journal Article
The Multifaceted Roles of Molecular Dynamics Simulations in Drug Discovery
Fox, Stephen John, Li, Jianguo, Tan, Yaw Sing, Nguyen, Minh N, Pal, Arumay, Ouaray, Zohra, Yadahalli, Shilpa, Kannan, Srinivasaraghavan
Published in Current pharmaceutical design (01.01.2016)
Published in Current pharmaceutical design (01.01.2016)
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Journal Article
Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells
Morkunas, Bernardas, Gal, Balint, Galloway, Warren R J D, Hodgkinson, James T, Ibbeson, Brett M, Tan, Yaw Sing, Welch, Martin, Spring, David R
Published in Beilstein journal of organic chemistry (11.07.2016)
Published in Beilstein journal of organic chemistry (11.07.2016)
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Journal Article
Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells
Low, Blaise Su Jun, Lim, Chang Siang, Ding, Shirley Suet Lee, Tan, Yaw Sing, Ng, Natasha Hui Jin, Krishnan, Vidhya Gomathi, Ang, Su Fen, Neo, Claire Wen Ying, Verma, Chandra S., Hoon, Shawn, Lim, Su Chi, Tai, E. Shyong, Teo, Adrian Kee Keong
Published in Nature communications (25.05.2021)
Published in Nature communications (25.05.2021)
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Journal Article
HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes
Ng, Natasha Hui Jin, Ghosh, Soumita, Bok, Chek Mei, Ching, Carmen, Low, Blaise Su Jun, Chen, Juin Ting, Lim, Euodia, Miserendino, María Clara, Tan, Yaw Sing, Hoon, Shawn, Teo, Adrian Kee Keong
Published in Nature communications (22.06.2024)
Published in Nature communications (22.06.2024)
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Journal Article
A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling
Beckmann, Henning S. G., Nie, Feilin, Hagerman, Caroline E., Johansson, Henrik, Tan, Yaw Sing, Wilcke, David, Spring, David R.
Published in Nature Chemistry (01.10.2013)
Published in Nature Chemistry (01.10.2013)
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Journal Article
Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription
Lau, Mei Sheng, Hu, Zhenhua, Zhao, Xiaodan, Tan, Yaw Sing, Liu, Jinyue, Huang, Hua, Yeo, Clarisse Jingyi, Leong, Hwei Fen, Grinchuk, Oleg V., Chan, Justin Kaixuan, Yan, Jie, Tee, Wee-Wei
Published in Nature communications (13.10.2023)
Published in Nature communications (13.10.2023)
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Journal Article
The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation
Nelson, Christopher B., Rogers, Samuel, Roychoudhury, Kaushik, Tan, Yaw Sing, Atkinson, Caroline J., Sobinoff, Alexander P., Tomlinson, Christopher G., Hsu, Anton, Lu, Robert, Dray, Eloise, Haber, Michelle, Fletcher, Jamie I., Cesare, Anthony J., Hegde, Rashmi S., Pickett, Hilda A.
Published in Nature communications (15.02.2024)
Published in Nature communications (15.02.2024)
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Journal Article
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides
Charoenpattarapreeda, Jiraborrirak, Tan, Yaw Sing, Iegre, Jessica, Walsh, Stephen J, Fowler, Elaine, Eapen, Rohan S, Wu, Yuteng, Sore, Hannah F, Verma, Chandra S, Itzhaki, Laura, Spring, David R
Published in Chemical Communications (14.07.2019)
Published in Chemical Communications (14.07.2019)
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Journal Article
The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein–Protein Interactions
Tan, Yaw Sing, Spring, David R, Abell, Chris, Verma, Chandra S
Published in Journal of Chemical Theory and Computation (14.07.2015)
Published in Journal of Chemical Theory and Computation (14.07.2015)
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Journal Article
The Use of Chlorobenzene as a Probe Molecule in Molecular Dynamics Simulations
Tan, Yaw Sing, Spring, David R, Abell, Chris, Verma, Chandra
Published in Journal of Chemical Information and Modeling (28.07.2014)
Published in Journal of Chemical Information and Modeling (28.07.2014)
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Journal Article
Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties
Partridge, Anthony W, Kaan, Hung Yi Kristal, Juang, Yu-Chi, Sadruddin, Ahmad, Lim, Shuhui, Brown, Christopher J, Ng, Simon, Thean, Dawn, Ferrer, Fernando, Johannes, Charles, Yuen, Tsz Ying, Kannan, Srinivasaraghavan, Aronica, Pietro, Tan, Yaw Sing, Pradhan, Mohan R, Verma, Chandra S, Hochman, Jerome, Chen, Shiying, Wan, Hui, Ha, Sookhee, Sherborne, Brad, Lane, David P, Sawyer, Tomi K
Published in Molecules (Basel, Switzerland) (20.06.2019)
Published in Molecules (Basel, Switzerland) (20.06.2019)
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Journal Article
Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles
Yuen, Tsz Ying, Brown, Christopher J, Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J, Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W, Verma, Chandra S, Lane, David P, Johannes, Charles W
Published in Chemical Science (14.07.2019)
Published in Chemical Science (14.07.2019)
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Journal Article
An Efficient, Short Stimulus PANC-1 Cancer Cell Ablation and Electrothermal Therapy Driven by Hydrophobic Interactions
Meivita, Maria P, Lee, Denise, Naikar, J Shamita, Go, Shao-Xiang, Teoh, Wey Chyi, Tan, Yaw Sing, Bajalovic, Natasa, Loke, Desmond K
Published in Pharmaceutics (28.12.2022)
Published in Pharmaceutics (28.12.2022)
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Journal Article
A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds
Isidro-Llobet, Albert, Hadje Georgiou, Kathy, Galloway, Warren R J D, Giacomini, Elisa, Hansen, Mette R, Méndez-Abt, Gabriela, Tan, Yaw Sing, Carro, Laura, Sore, Hannah F, Spring, David R
Published in Organic & Biomolecular Chemistry (21.04.2015)
Published in Organic & Biomolecular Chemistry (21.04.2015)
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Journal Article
Anatomy of Mdm2 and Mdm4 in evolution
Tan, Ban Xiong, Liew, Hoe Peng, Chua, Joy S, Ghadessy, Farid J, Tan, Yaw Sing, Lane, David P, Coffill, Cynthia R
Published in Journal of molecular cell biology (01.02.2017)
Published in Journal of molecular cell biology (01.02.2017)
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Journal Article
Inhibiting S100B(ββ) for Activating Wild-Type p53: Design of Stapled Peptides
Kannan, Srinivasaraghavan, Aronica, Pietro G. A, Tan, Yaw Sing, Verma, Chandra S
Published in ACS omega (31.03.2019)
Published in ACS omega (31.03.2019)
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Journal Article
Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1
Tan, Yaw Sing, Śledź, Paweł, Lang, Steffen, Stubbs, Christopher J., Spring, David R., Abell, Chris, Best, Robert B.
Published in Angewandte Chemie (01.10.2012)
Published in Angewandte Chemie (01.10.2012)
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Journal Article