Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket
Forster, Michael, Chaikuad, Apirat, Bauer, Silke M., Holstein, Julia, Robers, Matthew B., Corona, Cesear R., Gehringer, Matthias, Pfaffenrot, Ellen, Ghoreschi, Kamran, Knapp, Stefan, Laufer, Stefan A.
Published in Cell chemical biology (17.11.2016)
Published in Cell chemical biology (17.11.2016)
Get full text
Journal Article
Quantifying CDK inhibitor selectivity in live cells
Wells, Carrow I., Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Ingold, Morgan R., Pickett, Julie E., Drewry, David H., Pugh, Kathryn M., Schwinn, Marie K., Hwang, Byounghoon (Brian), Zegzouti, Hicham, Huber, Kilian V. M., Cong, Mei, Meisenheimer, Poncho L., Willson, Timothy M., Robers, Matthew B.
Published in Nature communications (02.06.2020)
Published in Nature communications (02.06.2020)
Get full text
Journal Article
A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins
Schwalm, Martin P., Berger, Lena M., Meuter, Maximilian N., Vasta, James D., Corona, Cesear R., Röhm, Sandra, Berger, Benedict-Tilman, Farges, Frederic, Beinert, Sebastian M., Preuss, Franziska, Morasch, Viktoria, Rogov, Vladimir V., Mathea, Sebastian, Saxena, Krishna, Robers, Matthew B., Müller, Susanne, Knapp, Stefan
Published in Frontiers in cell and developmental biology (26.05.2022)
Published in Frontiers in cell and developmental biology (26.05.2022)
Get full text
Journal Article
Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action
Riching, Kristin M, Mahan, Sarah, Corona, Cesear R, McDougall, Mark, Vasta, James D, Robers, Matthew B, Urh, Marjeta, Daniels, Danette L
Published in ACS chemical biology (21.09.2018)
Published in ACS chemical biology (21.09.2018)
Get full text
Journal Article
KRAS is vulnerable to reversible switch-II pocket engagement in cells
Vasta, James D., Peacock, D. Matthew, Zheng, Qinheng, Walker, Joel A., Zhang, Ziyang, Zimprich, Chad A., Thomas, Morgan R., Beck, Michael T., Binkowski, Brock F., Corona, Cesear R., Robers, Matthew B., Shokat, Kevan M.
Published in Nature chemical biology (01.06.2022)
Published in Nature chemical biology (01.06.2022)
Get full text
Journal Article
Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement
Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Hartnett, James R., Ingold, Morgan R., Zimmerman, Kristopher, Machleidt, Thomas, Kirkland, Thomas A., Huwiler, Kristin G., Ohana, Rachel Friedman, Slater, Michael, Otto, Paul, Cong, Mei, Wells, Carrow I., Berger, Benedict-Tilman, Hanke, Thomas, Glas, Carina, Ding, Ke, Drewry, David H., Huber, Kilian V.M., Willson, Timothy M., Knapp, Stefan, Müller, Susanne, Meisenheimer, Poncho L., Fan, Frank, Wood, Keith V., Robers, Matthew B.
Published in Cell Chemical Biology (15.02.2018)
Published in Cell Chemical Biology (15.02.2018)
Get full text
Journal Article
DELs enable the development of BRET probes for target engagement studies in cells
Teske, Kelly A, Su, Wenji, Corona, Cesear R, Wen, Jing, Deng, Jason, Ping, Yan, Zhang, Zaihong, Zhang, Qi, Wilkinson, Jennifer, Beck, Michael T, Nealey, Kendra R, Vasta, James D, Cong, Mei, Meisenheimer, Poncho L, Kuai, Letian, Robers, Matthew B
Published in Cell chemical biology (17.08.2023)
Published in Cell chemical biology (17.08.2023)
Get full text
Journal Article
Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites
Wittlinger, Florian, Heppner, David E, To, Ciric, Günther, Marcel, Shin, Bo Hee, Rana, Jaimin K, Schmoker, Anna M, Beyett, Tyler S, Berger, Lena M, Berger, Benedict-Tilman, Bauer, Nicolas, Vasta, James D, Corona, Cesear R, Robers, Matthew B, Knapp, Stefan, Jänne, Pasi A, Eck, Michael J, Laufer, Stefan A
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
Get full text
Journal Article
Small-molecule inhibition of the archetypal UbiB protein COQ8
Murray, Nathan H., Asquith, Christopher R. M., Fang, Zixiang, East, Michael P., Ptak, Naomi, Smith, Robert W., Vasta, James D., Zimprich, Chad A., Corona, Cesear R., Robers, Matthew B., Johnson, Gary L., Bingman, Craig A., Pagliarini, David J.
Published in Nature chemical biology (01.02.2023)
Published in Nature chemical biology (01.02.2023)
Get full text
Journal Article
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2
Němec, Václav, Remeš, Marek, Beňovský, Petr, Böck, Michael C., Šranková, Eliška, Wong, Jong Fu, Cros, Julien, Williams, Eleanor, Tse, Lap Hang, Smil, David, Ensan, Deeba, Isaac, Methvin B., Al-Awar, Rima, Gomolková, Regina, Ursachi, Vlad-Constantin, Fafílek, Bohumil, Kahounová, Zuzana, Víchová, Ráchel, Vacek, Ondřej, Berger, Benedict-Tilman, Wells, Carrow I., Corona, Cesear R., Vasta, James D., Robers, Matthew B., Krejci, Pavel, Souček, Karel, Bullock, Alex N., Knapp, Stefan, Paruch, Kamil
Published in Journal of medicinal chemistry (08.08.2024)
Published in Journal of medicinal chemistry (08.08.2024)
Get full text
Journal Article
Quantitative, Real-Time Measurements of Intracellular Target Engagement Using Energy Transfer
Robers, Matthew B., Vasta, James D., Corona, Cesear R., Ohana, Rachel Friedman, Hurst, Robin, Jhala, Manisha A., Comess, Kenneth M., Wood, Keith V.
Published in Methods in molecular biology (2019)
Published in Methods in molecular biology (2019)
Get more information
Book Chapter
Journal Article
Discovery of a selective inhibitor of doublecortin like kinase 1
Ferguson, Fleur M., Nabet, Behnam, Raghavan, Srivatsan, Liu, Yan, Leggett, Alan L., Kuljanin, Miljan, Kalekar, Radha L., Yang, Annan, He, Shuning, Wang, Jinhua, Ng, Raymond W. S., Sulahian, Rita, Li, Lianbo, Poulin, Emily J., Huang, Ling, Koren, Jost, Dieguez-Martinez, Nora, Espinosa, Sergio, Zeng, Zhiyang, Corona, Cesear R., Vasta, James D., Ohi, Ryoma, Sim, Taebo, Kim, Nam Doo, Harshbarger, Wayne, Lizcano, Jose M., Robers, Matthew B., Muthaswamy, Senthil, Lin, Charles Y., Look, A. Thomas, Haigis, Kevin M., Mancias, Joseph D., Wolpin, Brian M., Aguirre, Andrew J., Hahn, William C., Westover, Kenneth D., Gray, Nathanael S.
Published in Nature Chemical Biology (01.06.2020)
Published in Nature Chemical Biology (01.06.2020)
Get full text
Journal Article
Design of a “two-in-one” mutant-selective EGFR inhibitor that spans the orthosteric and allosteric sites
Wittlinger, Florian, Heppner, David E., To, Ciric, Günther, Marcel, Shin, Bo Hee, Rana, Jaimin K., Schmoker, Anna M., Beyett, Tyler S., Berger, Lena M., Berger, Benedict-Tilman, Bauer, Nicolas, Vasta, James D., Corona, Cesear R., Robers, Matthew B., Knapp, Stefan, Jänne, Pasi A., Eck, Michael J., Laufer, Stefan A.
Published in Journal of medicinal chemistry (20.10.2021)
Published in Journal of medicinal chemistry (20.10.2021)
Get full text
Journal Article
Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket
Forster, Michael, Chaikuad, Apirat, Bauer, Silke M, Holstein, Julia, Robers, Matthew B, Corona, Cesear R, Gehringer, Matthias, Pfaffenrot, Ellen, Ghoreschi, Kamran, Knapp, Stefan, Laufer, Stefan A
Published in Cell Chemical Biology (17.11.2016)
Published in Cell Chemical Biology (17.11.2016)
Get full text
Journal Article
Targeted Protein Degradation : Methods and Protocols
Abell, Kathryn, Bartoschik, Tanja, Bateman, Leslie A, Bond, Adam, Bondeson, Daniel P, Brackenridge, Danielle Allison, Buhimschi, Alexandru D, Carroll, Christopher W, Casement, Ryan, Chamberlain, Philip P, Ciulli, Alessio, Clayton, Thomas, Corona, Cesear R, Craigon, Conner, Daniels, Danette L, Demizu, Yosuke, Dhami, Kamaldeep S, Dobrodziej, Jennifer, Dong, Hanqing, Fischer, Eric S, Gross, Patrick H, Heffern, Charles, Henderson, Mark J, Hickey, Christopher M, Huang, XiaoDong, Hurley, Christina M, Kadimisetty, Karteek, Khambatta, Gody, Kraut, Daniel A, Mahan, Sarah D, Martinez, Natalia J, Matyskiela, Mary E, McGuffin, Liam James, Naito, Mikihiko, Nelson, Alissa J, Nowak, Radosław P, O’Connell, Nichole, Ohoka, Nobumichi, Ouazia, Dahmane, Owens, Ashley, Park, Emily Y, Possemato, Anthony P, Ren, Jian Min, Reynders, Martin, Riching, Kristin M, Robers, Matthew B, Rumpel, Klaus, Sanchez, Tino W, Sheets, Katie J, Shibata, Norihito, Simeonov, Anton, Smith, Blake E, Stokes, Matthew P, Thompson, Joel W, Trauner, Dirk, Tsuji, Genichiro, Tsukumo, Yoshinori, Urh, Marjeta, Vasta, James D, Wallgren, Eric, Yokoo, Hidetomo, Yue, Hong, Zerr, Myra J, Zhu, Yiying, Zimmermann, Kurt, Zoephel, Andreas
Year of Publication 01.01.2021
Year of Publication 01.01.2021
Get more information
eBook
KRAS is vulnerable to reversible switch-II pocket engagement in cells
Vasta, James D, Peacock, D Matthew, Zheng, Qinheng, Walker, Joel A, Zhang, Ziyang, Zimprich, Chad A, Thomas, Morgan R, Beck, Michael T, Binkowski, Brock F, Corona, Cesear R, Robers, Matthew B, Shokat, Kevan M
Published in Nature Chemical Biology (01.06.2022)
Get more information
Published in Nature Chemical Biology (01.06.2022)
Journal Article
Design of a ?Two-in-One? Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the
Wittlinger, Florian, Heppner, David E., To, Ciric, Gunther, Marcel, Shin, Bo Hee, Rana, Jaimin K., Schmoker, Anna M., Beyett, Tyler S., Berger, Lena M., Berger, Benedict-Tilman, Bauer, Nicolas, Vasta, James D., Corona, Cesear R., Robers, Matthew B., Knapp, Stefan, Janne, Pasi A., Eck, Michael J., Laufer, Stefan A.
Published in J. Med. Chem (01.10.2021)
Get more information
Published in J. Med. Chem (01.10.2021)
Journal Article
Design of a ?Two-in-One? Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the
Wittlinger, Florian, Heppner, David E., To, Ciric, Gunther, Marcel, Shin, Bo Hee, Rana, Jaimin K., Schmoker, Anna M., Beyett, Tyler S., Berger, Lena M., Berger, Benedict-Tilman, Bauer, Nicolas, Vasta, James D., Corona, Cesear R., Robers, Matthew B., Knapp, Stefan, Janne, Pasi A., Eck, Michael J., Laufer, Stefan A.
Published in J. Med. Chem (01.10.2021)
Get more information
Published in J. Med. Chem (01.10.2021)
Journal Article
Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action
Kristin M. Riching, Sarah Mahan, Cesear R. Corona, Mark McDougall, James D. Vasta, Matthew B. Robers, Marjeta Urh, Danette L. Daniels
Published in ACS Chemical Biology (23.08.2018)
Published in ACS Chemical Biology (23.08.2018)
Get more information
Journal Article