Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study
Finkel, Richard S, Dr, Chiriboga, Claudia A, MD, Vajsar, Jiri, MD, Day, John W, MD, Montes, Jacqueline, EdD, De Vivo, Darryl C, MD, Yamashita, Mason, MD, Rigo, Frank, PhD, Hung, Gene, MD, Schneider, Eugene, MD, Norris, Daniel A, PhD, Xia, Shuting, MS, Bennett, C Frank, PhD, Bishop, Kathie M, PhD
Published in The Lancet (British edition) (17.12.2016)
Published in The Lancet (British edition) (17.12.2016)
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STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial
Reilley, Matthew J, McCoon, Patricia, Cook, Carl, Lyne, Paul, Kurzrock, Razelle, Kim, Youngsoo, Woessner, Richard, Younes, Anas, Nemunaitis, John, Fowler, Nathan, Curran, Michael, Liu, Qinying, Zhou, Tianyuan, Schmidt, Joanna, Jo, Minji, Lee, Samantha J, Yamashita, Mason, Hughes, Steven G, Fayad, Luis, Piha-Paul, Sarina, Nadella, Murali V P, Xiao, Xiaokun, Hsu, Jeff, Revenko, Alexey, Monia, Brett P, MacLeod, A Robert, Hong, David S
Published in Journal for immunotherapy of cancer (16.11.2018)
Published in Journal for immunotherapy of cancer (16.11.2018)
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AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer
Hong, David, Kurzrock, Razelle, Kim, Youngsoo, Woessner, Richard, Younes, Anas, Nemunaitis, John, Fowler, Nathan, Zhou, Tianyuan, Schmidt, Joanna, Jo, Minji, Lee, Samantha J, Yamashita, Mason, Hughes, Steven G, Fayad, Luis, Piha-Paul, Sarina, Nadella, Murali V P, Mohseni, Morvarid, Lawson, Deborah, Reimer, Corinne, Blakey, David C, Xiao, Xiaokun, Hsu, Jeff, Revenko, Alexey, Monia, Brett P, MacLeod, A Robert
Published in Science translational medicine (18.11.2015)
Published in Science translational medicine (18.11.2015)
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New Insights into Inhibitor Design from the Crystal Structure and NMR Studies of Escherichia coli GAR Transformylase in Complex with β-GAR and 10-Formyl-5,8,10-trideazafolic Acid
Greasley, Samantha E, Yamashita, Mason M, Cai, Hui, Benkovic, Stephen J, Boger, Dale L, Wilson, Ian A
Published in Biochemistry (Easton) (21.12.1999)
Published in Biochemistry (Easton) (21.12.1999)
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Emricasan (IDN‐6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension
Garcia‐Tsao, Guadalupe, Fuchs, Michael, Shiffman, Mitchell, Borg, Brian B., Pyrsopoulos, Nikolaos, Shetty, Kirti, Gallegos‐Orozco, Juan F., Reddy, K. Rajender, Feyssa, Eyob, Chan, Jean L., Yamashita, Mason, Robinson, James M., Spada, Alfred P., Hagerty, David T., Bosch, Jaime
Published in Hepatology (Baltimore, Md.) (01.02.2019)
Published in Hepatology (Baltimore, Md.) (01.02.2019)
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Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo
Frenette, Catherine T., Morelli, Giuseppe, Shiffman, Mitchell L., Frederick, R. Todd, Rubin, Raymond A., Fallon, Michael B., Cheng, Jason T., Cave, Matt, Khaderi, Saira A., Massoud, Omar, Pyrsopoulos, Nikolaos, Park, James S., Robinson, James M., Yamashita, Mason, Spada, Alfred P., Chan, Jean L., Hagerty, David T.
Published in Clinical gastroenterology and hepatology (01.03.2019)
Published in Clinical gastroenterology and hepatology (01.03.2019)
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A pH-dependent stabilization of an active site loop observed from low and high ph crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 Å
Su, Ying, Yamashita, Mason M, Greasley, Samantha E, Mullen, Christine A, Shim, Jae Hoon, Jennings, Patricia A, Benkovic, Steven J, Wilson, Ian A
Published in Journal of molecular biology (21.08.1998)
Published in Journal of molecular biology (21.08.1998)
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Results of a proof of concept, double-blind, randomized trial of a second generation antisense oligonucleotide targeting high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis
Warren, Marshelle S, Hughes, Steven G, Singleton, Walter, Yamashita, Mason, Genovese, Mark C
Published in Arthritis research & therapy (19.03.2015)
Published in Arthritis research & therapy (19.03.2015)
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Factors to Consider in Development of Drugs for Pediatric Nonalcoholic Fatty Liver Disease
Vos, Miriam B., Dimick-Santos, Lara, Mehta, Ruby, Omokaro, Stephanie O., Taminiau, Johannes, Taminiau, Johannes, Schabel, Elmer, Schabel, Elmer, Kleiner, David E., Kleiner, David E., Szitanyi, Peter, Szitanyi, Peter, Socha, Piotr, Socha, Piotr, Schwimmer, Jeffrey B., Schwimmer, Jeffrey B., Noviello, Stephanie, Noviello, Stephanie, Silberg, Debra G., Torstenson, Richard, Torstenson, Richard, Miller, Veronica, Miller, Veronica, Lavine, Joel E., Adda, Nathalie, Baldyga, William, Banerjee, Rajarshi, Behling, Cynthia, Boulos, Sherif, Burgess, Gary, Calboli, Dania, Charles, Edgar, Christian, Rose, Cohen-Bacrie, Claude, Cosma-Roman, Doina, Danzer, Claus-Peter, Delaet, Ingrid, Delegge, Mark, DiProspero, Nicholas, Donohue, Kathleen, Fischer, Laurent, Fitzpatrick, Emer, Fried, Michael, Hagerty, David, Hale, Paula, Hildick, Keri, Hum, Dean, Jamil, Khurram, Jiang, Lijuan, Karpen, Saul, Kelly, Matt, Kohli, Rohit, Kordy, Kattayoun, Krieger, Nancy, Lavine, Joel, Lee, Lois, Lefebvre, Eric, Lopez, Patricia, Lyons, Erica, Malahias, Laura, Megnien, Sophie, Mesenbrink, Peter, Minnick, Pansy, Murray, Christine, Nghiem, Tien, Nicholson, Nikki, Pang, Wenjie, Percival, Lisa, Peres, Dan, Powell, Margaret, Roman, Dragos, Root, Mark, Sampson, Claire, Sanyal, Arun, Schwarz, Kathleen, Seyedkazemi, Star, Shapiro, David, Shringarpure, Reshma, Silberg, Debra, Smith, Edward, Squires, Robert, Treem, William, Vig, Pamela, Vos, Miriam, Yamashita, Mason, Zemel, Michael
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2019)
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2019)
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Abstract CT239: Clinical and preclinical evidence of an immune modulating role for the STAT3-targeting ASO AZD9150 and potential to enhance clinical responses to anti-PDL1 therapy
Mccoon, Patricia E., Woessner, Rich, Grosskurth, Shaun, Womack, Chris, Yamashita, Mason, Hung, Gene, MacLeod, Robert, Bell, Kirsten, Collins, Mike, DuPont, Rachel, Jacobs, Vivian, Johnstone, Michele, Veldman-Jones, Margaret, Lyne, Paul
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract LB-227: Preclinical pharmacology and clinical efficacy of AZD9150 (ISIS-STAT3Rx), a potent next-generation antisense oligonucleotide inhibitor of STAT3
Hong, David, Kim, Youngsoo, Younes, Anas, Nemunaitis, John, Fowler, Nathan, Hsu, Jeff, Zhou, Tianyuan, Fayad, Luis, Zhang, Nancy, Piha-Paul, Sarina, Woessner, Richard, Nadella, Murali V., Lawson, Deborah, Reimer, Corinne, Jo, Minji, Schmidt, Joanna, Xiao, Xiaokun, Greenlee, Sarah, Hung, Gene, Yamashita, Mason, Blakey, David C., Monia, Brett P., Macleod, A. Robert, Kurzrock, Razelle
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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A phase I study of ISIS 481464 (AZD9150), a first-in-human, first-in-class, antisense oligonucleotide inhibitor of STAT3, in patients with advanced cancers
Hong, David S., Younes, Anas, Fayad, Luis, Fowler, Nathan Hale, Hagemeister, Fredrick B., Mistry, Reena, Nemunaitis, John J., Borad, Mitesh J., Bryce, Alan H., Yamashita, Mason, Hughes, Steven George, Kwoh, Theodore Jesse, MacLeod, A. Robert, Norris, Dan, Baldwin, Ron, Hung, Gene, Monia, Brett P., Kurzrock, Razelle
Published in Journal of clinical oncology (20.05.2013)
Published in Journal of clinical oncology (20.05.2013)
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