Advances in high‐throughput mass spectrometry in drug discovery
Dueñas, Maria Emilia, Peltier‐Heap, Rachel E, Leveridge, Melanie, Annan, Roland S, Büttner, Frank H, Trost, Matthias
Published in EMBO molecular medicine (11.01.2023)
Published in EMBO molecular medicine (11.01.2023)
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Journal Article
A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1
Müller, Leonie, Burton, Amy K, Tayler, Chloe L, Rowedder, James E, Hutchinson, Jonathan P, Peace, Simon, Quayle, Julie M, Leveridge, Melanie V, Annan, Roland S, Trost, Matthias, Peltier-Heap, Rachel E, Dueñas, Maria Emilia
Published in SLAS discovery (01.01.2023)
Published in SLAS discovery (01.01.2023)
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Journal Article
A direct-to-biology high-throughput chemistry approach to reactive fragment screening
Thomas, Ross P, Heap, Rachel E, Zappacosta, Francesca, Grant, Emma K, Pogány, Peter, Besley, Stephen, Fallon, David J, Hann, Michael M, House, David, Tomkinson, Nicholas C. O, Bush, Jacob T
Published in Chemical science (Cambridge) (22.09.2021)
Published in Chemical science (Cambridge) (22.09.2021)
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Journal Article
Mass spectrometry techniques for studying the ubiquitin system
Heap, Rachel E, Gant, Megan S, Lamoliatte, Frederic, Peltier, Julien, Trost, Matthias
Published in Biochemical Society transactions (15.10.2017)
Published in Biochemical Society transactions (15.10.2017)
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Journal Article
Profiling embryonic stem cell differentiation by MALDI TOF mass spectrometry: development of a reproducible and robust sample preparation workflow
Heap, Rachel E, Segarra-Fas, Anna, Blain, Alasdair P, Findlay, Greg M, Trost, Matthias
Published in Analyst (London) (22.10.2019)
Published in Analyst (London) (22.10.2019)
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Journal Article
A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia
Marín-Rubio, José Luis, Peltier-Heap, Rachel E., Dueñas, Maria Emilia, Heunis, Tiaan, Dannoura, Abeer, Inns, Joseph, Scott, Jonathan, Simpson, A. John, Blair, Helen J., Heidenreich, Olaf, Allan, James M., Watt, Jessica E., Martin, Mathew P., Saxty, Barbara, Trost, Matthias
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Journal Article
Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)
Heap, Rachel E., Hope, Anthony G., Pearson, Lesley-Anne, Reyskens, Kathleen M. S. E., McElroy, Stuart P., Hastie, C. James, Porter, David W., Arthur, J. Simon C., Gray, David W., Trost, Matthias
Published in SLAS discovery (01.12.2017)
Published in SLAS discovery (01.12.2017)
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Journal Article
A chemoproteomic platform for selective deubiquitinase inhibitor discovery
Cookson, Rosa, Vuorinen, Aini, Pettinger, Jonathan, Kennedy, Cassandra R., Kirkpatrick, Joanna M., Peltier-Heap, Rachel E., Powell, Andrew, Snijders, Ambrosius P., Skehel, Mark, House, David, Rittinger, Katrin, Bush, Jacob T.
Published in Cell reports physical science (18.10.2023)
Published in Cell reports physical science (18.10.2023)
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Journal Article
A chemoproteomic platform for reactive fragment profiling against the deubiquitinases
Cookson, Rosa, Vuorinen, Aini, Pettinger, Jonathan, Kennedy, Cassandra R, Kirkpatrick, Joanna M, Peltier-Heap, Rachel E, Powell, Andrew, Snijders, Ambrosius P, Skehel, Mark, House, David, Rittinger, Katrin, Bush, Jacob T
Published in bioRxiv (03.02.2023)
Published in bioRxiv (03.02.2023)
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A MALDI-TOF assay identifies nilotinib as an inhibitor of inflammation in acute myeloid leukaemia
Marin-Rubio, José Luis, Heap, Rachel E, Heunis, Tiaan, Dueñas, Maria Emilia, Inns, Joseph, Scott, Jonathan, Simpson, A John, James Mark Allan, Blair, Helen, Heidenreich, Olaf, Saxty, Barbara, Trost, Matthias
Published in bioRxiv (29.03.2022)
Published in bioRxiv (29.03.2022)
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