Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation
Zeqiraj, Elton, Filippi, Beatrice Maria, Deak, Maria, Alessi, Dario R., van Aalten, Daan M. F.
Published in Science (American Association for the Advancement of Science) (18.12.2009)
Published in Science (American Association for the Advancement of Science) (18.12.2009)
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O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis
Soria, Leandro R., Makris, Georgios, D’Alessio, Alfonso M., De Angelis, Angela, Boffa, Iolanda, Pravata, Veronica M., Rüfenacht, Véronique, Attanasio, Sergio, Nusco, Edoardo, Arena, Paola, Ferenbach, Andrew T., Paris, Debora, Cuomo, Paola, Motta, Andrea, Nitzahn, Matthew, Lipshutz, Gerald S., Martínez-Pizarro, Ainhoa, Richard, Eva, Desviat, Lourdes R., Häberle, Johannes, van Aalten, Daan M. F., Brunetti-Pierri, Nicola
Published in Nature communications (05.09.2022)
Published in Nature communications (05.09.2022)
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Intellectual disability-associated disruption of O-GlcNAc cycling impairs habituation learning in Drosophila
Fenckova, Michaela, Muha, Villo, Mariappa, Daniel, Catinozzi, Marica, Czajewski, Ignacy, Blok, Laura E R, Ferenbach, Andrew T, Storkebaum, Erik, Schenck, Annette, van Aalten, Daan M F
Published in PLoS genetics (02.05.2022)
Published in PLoS genetics (02.05.2022)
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A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations
Raich, Lluís, Borodkin, Vladimir, Fang, Wenxia, Castro-López, Jorge, van Aalten, Daan M. F, Hurtado-Guerrero, Ramón, Rovira, Carme
Published in Journal of the American Chemical Society (16.03.2016)
Published in Journal of the American Chemical Society (16.03.2016)
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Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases
Fang, Wenxia, Sanz, Ana Belén, Bartual, Sergio Galan, Wang, Bin, Ferenbach, Andrew T., Farkaš, Vladimír, Hurtado-Guerrero, Ramon, Arroyo, Javier, van Aalten, Daan M. F.
Published in Nature communications (10.04.2019)
Published in Nature communications (10.04.2019)
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Analysis of the LKB1-STRAD-MO25 complex
Boudeau, Jérôme, Scott, John W, Resta, Nicoletta, Deak, Maria, Kieloch, Agnieszka, Komander, David, Hardie, D Grahame, Prescott, Alan R, van Aalten, Daan M F, Alessi, Dario R
Published in Journal of cell science (15.12.2004)
Published in Journal of cell science (15.12.2004)
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TAK1-binding protein 1 is a pseudophosphatase
Conner, Sarah H, Kular, Gursant, Peggie, Mark, Shepherd, Sharon, Schüttelkopf, Alexander W, Cohen, Philip, Van Aalten, Daan M F
Published in Biochemical journal (01.11.2006)
Published in Biochemical journal (01.11.2006)
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The citron homology domain as a scaffold for Rho1 signaling
Bartual, Sergio G., Wei, Wenfan, Zhou, Yao, Pravata, Veronica M., Fang, Wenxia, Yan, Kaizhou, Ferenbach, Andrew T., Lockhart, Deborah E. A., van Aalten, Daan M. F.
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.2021)
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UDP‐GlcNAc Analogues as Inhibitors of O‐GlcNAc Transferase (OGT): Spectroscopic, Computational, and Biological Studies
Ghirardello, Mattia, Perrone, Daniela, Chinaglia, Nicola, Sádaba, David, Delso, Ignacio, Tejero, Tomas, Marchesi, Elena, Fogagnolo, Marco, Rafie, Karim, van Aalten, Daan M. F., Merino, Pedro
Published in Chemistry : a European journal (17.05.2018)
Published in Chemistry : a European journal (17.05.2018)
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The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces
Wong, Edmond, Vaaje-Kolstad, Gustav, Ghosh, Avishek, Hurtado-Guerrero, Ramon, Konarev, Peter V, Ibrahim, Adel F M, Svergun, Dmitri I, Eijsink, Vincent G H, Chatterjee, Nabendu S, van Aalten, Daan M F
Published in PLoS pathogens (01.01.2012)
Published in PLoS pathogens (01.01.2012)
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Substrate and product analogues as human O-GlcNAc transferase inhibitors
Dorfmueller, Helge C, Borodkin, Vladimir S, Blair, David E, Pathak, Shalini, Navratilova, Iva, van Aalten, Daan M. F
Published in Amino acids (01.03.2011)
Published in Amino acids (01.03.2011)
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Structure and Mechanism of Chitin Deacetylase from the Fungal Pathogen Colletotrichum lindemuthianum
Blair, David E, Hekmat, Omid, Schüttelkopf, Alexander W, Shrestha, Binesh, Tokuyasu, Ken, Withers, Stephen G, van Aalten, Daan M. F
Published in Biochemistry (Easton) (08.08.2006)
Published in Biochemistry (Easton) (08.08.2006)
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Tissue-specific O- GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning
Yu, Haibin, Liu, Dandan, Zhang, Yaowen, Tang, Ruijun, Fan, Xunan, Mao, Song, Lv, Lu, Chen, Fang, Qin, Hongtao, Zhang, Zhuohua, van Alten, Daan M F, Yang, Bing, Yuan, Kai
Published in eLife (15.04.2024)
Published in eLife (15.04.2024)
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BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm
Hobley, Laura, Ostrowski, Adam, Rao, Francesco V., Bromley, Keith M., Porter, Michael, Prescott, Alan R., MacPhee, Cait E., van Aalten, Daan M. F., Stanley-Wall, Nicola R.
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2013)
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Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance
Bayascas, Jose R., Wullschleger, Stephan, Sakamoto, Kei, García-Martínez, Juan M., Clacher, Carol, Komander, David, van Aalten, Daan M. F., Boini, Krishna M., Lang, Florian, Lipina, Christopher, Logie, Lisa, Sutherland, Calum, Chudek, John A., van Diepen, Janna A., Voshol, Peter J., Lucocq, John M., Alessi, Dario R.
Published in Molecular and Cellular Biology (01.05.2008)
Published in Molecular and Cellular Biology (01.05.2008)
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Molecular Mechanisms of Yeast Cell Wall Glucan Remodeling
Hurtado-Guerrero, Ramon, Schüttelkopf, Alexander W., Mouyna, Isabelle, Ibrahim, Adel F.M., Shepherd, Sharon, Fontaine, Thierry, Latgé, Jean-Paul, van Aalten, Daan M.F.
Published in The Journal of biological chemistry (27.03.2009)
Published in The Journal of biological chemistry (27.03.2009)
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Proteome Wide Purification and Identification of O‑GlcNAc-Modified Proteins Using Click Chemistry and Mass Spectrometry
Hahne, Hannes, Sobotzki, Nadine, Nyberg, Tamara, Helm, Dominic, Borodkin, Vladimir S, van Aalten, Daan M. F, Agnew, Brian, Kuster, Bernhard
Published in Journal of proteome research (01.02.2013)
Published in Journal of proteome research (01.02.2013)
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Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations
Woodroof, Helen I., Pogson, Joe H., Begley, Mike, Cantley, Lewis C., Deak, Maria, Campbell, David G., van Aalten, Daan M. F., Whitworth, Alexander J., Alessi, Dario R., Muqit, Miratul M. K.
Published in Open biology (01.11.2011)
Published in Open biology (01.11.2011)
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