Search Results - "MOHAMED EL BOUSMAQUI" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model

N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model

by Hoveyda, Hamid R., Fraser, Graeme L., Zoute, Ludivine, Dutheuil, Guillaume, Schils, Didier, Brantis, Cyrille, Lapin, Alexey, Parcq, Julien, Guitard, Sandra, Lenoir, François, Bousmaqui, Mohamed El, Rorive, Sarah, Hospied, Sandrine, Blanc, Sébastien, Bernard, Jérôme, Ooms, Frédéric, McNelis, Joanne C., Olefsky, Jerrold M.
Published in Bioorganic & medicinal chemistry (01.10.2018)

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Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof

Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof

by Roy, Marie-Odile, El Bousmaqui, Mohamed, Batt, Frederic, Fraser, Graeme Lovat, Hoveyda, Hamid R, Dutheuil, Guillaume
Year of Publication 09.03.2021

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Patent

NOVEL CHIRAL N-ACYL-5,6,7(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

NOVEL CHIRAL N-ACYL-5,6,7(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

by Roy, Marie-Odile, Batt, Frederic, Fraser, Graeme Lovat, Hoveyda, Hamid R, Dutheuil, Guillaume, Bousmaqui, Mohamed El
Year of Publication 10.09.2020

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Patent

Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof

Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof

by Roy, Marie-Odile, Batt, Frederic, Fraser, Graeme Lovat, Hoveyda, Hamid R, Dutheuil, Guillaume, Bousmaqui, Mohamed El
Year of Publication 16.06.2020

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Patent

NOVEL CHIRAL N-ACYL-5,6,7(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

NOVEL CHIRAL N-ACYL-5,6,7(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

by Roy, Marie-Odile, Batt, Frederic, Fraser, Graeme Lovat, Hoveyda, Hamid R, Dutheuil, Guillaume, Bousmaqui, Mohamed El
Year of Publication 24.01.2019

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Patent

Novel chiral N-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof

Novel chiral N-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof

by Roy, Marie-Odile, Fraser, Graeme, Hoveyda, Hamid, El Bousmaqui, Mohamed, Batt, Frederic, Dutheuil, Guillaume
Year of Publication 19.07.2018

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Patent

Novel chiral N-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof

Novel chiral N-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof

by Roy, Marie-Odile, Fraser, Graeme, Hoveyda, Hamid, El Bousmaqui, Mohamed, Batt, Frederic, Dutheuil, Guillaume
Year of Publication 06.07.2017

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Patent

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

by Hoveyda Hamid, Fraser Graeme, Bousmaqui Mohamed El, Batt Frédéric, Dutheuil Guillaume, Roy Marie-Odile
Year of Publication 02.02.2017

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Patent

Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof

Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof

by Batt Frederic, El Bousmaqui Mohamed, Fraser Graeme L, Dutheuil Guillaume, Hoveyda Hamid R, Roy Marie-Odile
Year of Publication 25.10.2016

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Patent

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

by Roy, Marie-Odile, Fraser, Graeme, El Bousmaqui, Mohamed, Dutheuil, Guillaume, Hoveyeda, Hamid, Batt, Frédéric
Year of Publication 15.07.2016

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Patent

CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

by HOVEYDA, HAMID, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME, BATT, FREDERIC
Year of Publication 11.06.2019

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Patent

N-acil-5,6,7, (8-substituído) - tetraidro-[1,2,4] triazolo [4,3 -a] pirazinas quirais inovadoras como antagonistas de receptor de nk-3 seletivos, composição farmacêutica, métodos para usar em distúrbios mediados por receptor de nk-3 e síntese quiral dos mesmos

N-acil-5,6,7, (8-substituído) - tetraidro-[1,2,4] triazolo [4,3 -a] pirazinas quirais inovadoras como antagonistas de receptor de nk-3 seletivos, composição farmacêutica, métodos para usar em distúrbios mediados por receptor de nk-3 e síntese quiral dos mesmos

by DUTHEUIL GUILLAUME, BATT FRÉDÉRIC, ROY MARIE-ODILE, FRASER GRAEME, MOHAMED EL BOUSMAQUI, HOVEYDA HAMID
Year of Publication 17.05.2022

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Patent

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-(1,2,4)TRIAZOLO(4,3-A)PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-(1,2,4)TRIAZOLO(4,3-A)PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS

by ROY Marie-Odile, FRASER Graeme, EL BOUSMAQUI Mohamed, BATT Frederic, HOVEYEDA Hamid, DUTHEUIL Guillaume
Year of Publication 31.08.2016

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Patent

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS

by BATT, FRÉDÉRIC, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME, HOVEYEDA, HAMID
Year of Publication 31.08.2016

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Patent

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS

by BATT, FRÉDÉRIC, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME, HOVEYEDA, HAMID
Year of Publication 24.08.2016

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Patent

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

by BATT, FRÉDÉRIC, HOVEYDA, HAMID, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME
Year of Publication 08.06.2016

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Patent

HIDTIL UKENDTE CHIRALE N-ACYL-5,6,7,(8-SUBSTITUERET)-TETRAHYDRO-[1,2,4]TRIAZOL[4,3-A]PYRAZINER SOM SELEKTIVE NK-3-RECEPTORANTAGONISTER, FARMACEUTISK SAMMENSÆTNING OG FREMGANGSMÅDER TIL ANVENDELSE VED NK-3-RECEPTORMEDIEREDE SYGDOMME

HIDTIL UKENDTE CHIRALE N-ACYL-5,6,7,(8-SUBSTITUERET)-TETRAHYDRO-[1,2,4]TRIAZOL[4,3-A]PYRAZINER SOM SELEKTIVE NK-3-RECEPTORANTAGONISTER, FARMACEUTISK SAMMENSÆTNING OG FREMGANGSMÅDER TIL ANVENDELSE VED NK-3-RECEPTORMEDIEREDE SYGDOMME

by BATT, FRÉDÉRIC, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, FRASER, GRAEME, DUTHEUIL, GUILLAUME, HOVEYEDA, HAMID
Year of Publication 25.04.2016

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Patent

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS

by BATT, FRÉDÉRIC, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME, HOVEYEDA, HAMID
Year of Publication 06.04.2016

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Patent

Novel chiral n-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor mediated disorders and chiral synthesis thereof

Novel chiral n-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor mediated disorders and chiral synthesis thereof

by DUTHEUIL GUILLAUME, ROY MARIE-ODILE, FRASER GRAEME, EL BOUSMAQUI MOHAMED, BATT FREDERIC, HOVEYDA HAMID
Year of Publication 23.12.2015

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Patent

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS

by BATT, FRÉDÉRIC, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME, HOVEYEDA, HAMID
Year of Publication 13.08.2014

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Patent