Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies
Kawana, Masataka, Spudich, James A, Ruppel, Kathleen M
Published in Frontiers in physiology (26.09.2022)
Published in Frontiers in physiology (26.09.2022)
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Cryo-EM structure of the folded-back state of human β-cardiac myosin
Grinzato, Alessandro, Auguin, Daniel, Kikuti, Carlos, Nandwani, Neha, Moussaoui, Dihia, Pathak, Divya, Kandiah, Eaazhisai, Ruppel, Kathleen M., Spudich, James A., Houdusse, Anne, Robert-Paganin, Julien
Published in Nature communications (31.05.2023)
Published in Nature communications (31.05.2023)
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β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Nature communications (18.06.2019)
Published in Nature communications (18.06.2019)
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Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
Morck, Makenna M, Bhowmik, Debanjan, Pathak, Divya, Dawood, Aminah, Spudich, James, Ruppel, Kathleen M
Published in eLife (29.06.2022)
Published in eLife (29.06.2022)
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Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin
Sommese, Ruth F, Nag, Suman, Sutton, Shirley, Miller, Susan M, Spudich, James A, Ruppel, Kathleen M
Published in PloS one (18.12.2013)
Published in PloS one (18.12.2013)
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Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level
Liu, Chao, Kawana, Masataka, Song, Dan, Ruppel, Kathleen M., Spudich, James A.
Published in Nature structural & molecular biology (01.06.2018)
Published in Nature structural & molecular biology (01.06.2018)
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Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers
Anderson, Robert L., Trivedi, Darshan V., Sarkar, Saswata S., Henze, Marcus, Ma, Weikang, Gong, Henry, Rogers, Christopher S., Gorham, Joshua M., Wong, Fiona L., Morck, Makenna M., Seidman, Jonathan G., Ruppel, Kathleen M., Irving, Thomas C., Cooke, Roger, Green, Eric M., Spudich, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2018)
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The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches
Trivedi, Darshan V, Nag, Suman, Spudich, Annamma, Ruppel, Kathleen M, Spudich, James A
Published in Annual review of biochemistry (20.06.2020)
Published in Annual review of biochemistry (20.06.2020)
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Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state
Vander Roest, Alison Schroer, Liu, Chao, Morck, Makenna M, Kooiker, Kristina Bezold, Jung, Gwanghyun, Song, Dan, Dawood, Aminah, Jhingran, Arnav, Pardon, Gaspard, Ranjbarvaziri, Sara, Fajardo, Giovanni, Zhao, Mingming, Campbell, Kenneth S, Pruitt, Beth L, Spudich, James A, Ruppel, Kathleen M, Bernstein, Daniel
Published in Proceedings of the National Academy of Sciences - PNAS (15.06.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (15.06.2021)
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Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation
Liu, Chao, Karabina, Anastasia, Meller, Artur, Bhattacharjee, Ayan, Agostino, Colby J, Bowman, Greg R, Ruppel, Kathleen M, Spudich, James A, Leinwand, Leslie A
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2024)
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Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation
Homburger, Julian R., Green, Eric M., Caleshu, Colleen, Sunitha, Margaret S., Taylor, Rebecca E., Ruppel, Kathleen M., Metpally, Raghu Prasad Rao, Colan, Steven D., Michels, Michelle, Day, Sharlene M., Olivotto, Iacopo, Bustamante, Carlos D., Dewey, Frederick E., Ho, Carolyn Y., Spudich, James A., Ashley, Euan A.
Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2016)
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Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin
Adhikari, Arjun S., Kooiker, Kristina B., Sarkar, Saswata S., Liu, Chao, Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Cell reports (Cambridge) (13.12.2016)
Published in Cell reports (Cambridge) (13.12.2016)
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Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration
Lee, Soah, Vander Roest, Alison S, Blair, Cheavar A, Kao, Kerry, Bremner, Samantha B, Childers, Matthew C, Pathak, Divya, Heinrich, Paul, Lee, Daniel, Chirikian, Orlando, Mohran, Saffie E, Roberts, Brock, Smith, Jacqueline E, Jahng, James W, Paik, David T, Wu, Joseph C, Gunawardane, Ruwanthi N, Ruppel, Kathleen M, Mack, David L, Pruitt, Beth L, Regnier, Michael, Wu, Sean M, Spudich, James A, Bernstein, Daniel
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2024)
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Journal Article
Controlling load-dependent kinetics of [beta]-cardiac myosin at the single-molecule level
Liu, Chao, Kawana, Masataka, Song, Dan, Ruppel, Kathleen M, Spudich, James A
Published in Nature structural & molecular biology (01.06.2018)
Published in Nature structural & molecular biology (01.06.2018)
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Journal Article
Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-Bridge Kinetics of Human [beta]-Cardiac Myosin
Sommese, Ruth F, Nag, Suman, Sutton, Shirley, Miller, Susan M, Spudich, James A, Ruppel, Kathleen M
Published in PloS one (18.12.2013)
Published in PloS one (18.12.2013)
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Journal Article
Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
Morck, Makenna, Bhowmik, Debanjan, Dawood, Aminah, Spudich, James, Ruppel, Kathleen M
Published in bioRxiv (12.10.2021)
Published in bioRxiv (12.10.2021)
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Paper
Controlling load-dependent contractility of the heart at the single molecule level
Liu, Chao, Kawana, Masataka, Song, Dan, Ruppel, Kathleen M, Spudich, James
Published in bioRxiv (05.04.2018)
Published in bioRxiv (05.04.2018)
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