Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins
Gault, Joseph, Liko, Idlir, Landreh, Michael, Shutin, Denis, Bolla, Jani Reddy, Jefferies, Damien, Agasid, Mark, Yen, Hsin-Yung, Ladds, Marcus J. G. W., Lane, David P., Khalid, Syma, Mullen, Christopher, Remes, Philip M., Huguet, Romain, McAlister, Graeme, Goodwin, Michael, Viner, Rosa, Syka, John E.P., Robinson, Carol V.
Published in Nature methods (01.05.2020)
Published in Nature methods (01.05.2020)
Get full text
Journal Article
Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
Popova, Gergana, Ladds, Marcus J. G. W, Johansson, Lars, Saleh, Aljona, Larsson, Johanna, Sandberg, Lars, Sahlberg, Sara Häggblad, Qian, Weixing, Gullberg, Hjalmar, Garg, Neeraj, Gustavsson, Anna-Lena, Haraldsson, Martin, Lane, David, Yngve, Ulrika, Lain, Sonia
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
Get full text
Journal Article
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology
Ladds, Marcus J. G.W., Popova, Gergana, Pastor-Fernández, Andrés, Kannan, Srinivasaraghavan, van Leeuwen, Ingeborg M.M., Håkansson, Maria, Walse, Björn, Tholander, Fredrik, Bhatia, Ravi, Verma, Chandra S., Lane, David P., Laín, Sonia
Published in The Journal of biological chemistry (25.12.2020)
Published in The Journal of biological chemistry (25.12.2020)
Get full text
Journal Article
Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase
Costeira-Paulo, Joana, Gault, Joseph, Popova, Gergana, Ladds, Marcus J.G.W., van Leeuwen, Ingeborg M.M., Sarr, Médoune, Olsson, Anders, Lane, David P., Laín, Sonia, Marklund, Erik G., Landreh, Michael
Published in Cell chemical biology (15.03.2018)
Published in Cell chemical biology (15.03.2018)
Get full text
Journal Article
Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner
McCarthy, Anna R, Sachweh, Marijke C C, Higgins, Maureen, Campbell, Johanna, Drummond, Catherine J, van Leeuwen, Ingeborg M M, Pirrie, Lisa, Ladds, Marcus J G W, Westwood, Nicholas J, Laín, Sonia
Published in Molecular cancer therapeutics (01.04.2013)
Published in Molecular cancer therapeutics (01.04.2013)
Get full text
Journal Article