A novel Cas9 fusion protein promotes targeted genome editing with reduced mutational burden in primary human cells
Carusillo, Antonio, Haider, Sibtain, Schäfer, Raul, Rhiel, Manuel, Türk, Daniel, Chmielewski, Kay O, Klermund, Julia, Mosti, Laura, Andrieux, Geoffroy, Schäfer, Richard, Cornu, Tatjana I, Cathomen, Toni, Mussolino, Claudio
Published in Nucleic acids research (22.05.2023)
Published in Nucleic acids research (22.05.2023)
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Correction of IVS I-110(G>A) β-thalassemia by CRISPR/Cas-and TALEN-mediated disruption of aberrant regulatory elements in human hematopoietic stem and progenitor cells
Patsali, Petros, Turchiano, Giandomenico, Papasavva, Panayiota, Romito, Marianna, Loucari, Constantinos C, Stephanou, Coralea, Christou, Soteroulla, Sitarou, Maria, Mussolino, Claudio, Cornu, Tatjana I, Antoniou, Michael N, Lederer, Carsten W, Cathomen, Toni, Kleanthous, Marina
Published in Haematologica (Roma) (01.11.2019)
Published in Haematologica (Roma) (01.11.2019)
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T-CAST: An optimized CAST-Seq pipeline for TALEN confirms superior safety and efficacy of obligate-heterodimeric scaffolds
Rhiel, Manuel, Geiger, Kerstin, Andrieux, Geoffroy, Rositzka, Julia, Boerries, Melanie, Cathomen, Toni, Cornu, Tatjana I
Published in Frontiers in genome editing (20.02.2023)
Published in Frontiers in genome editing (20.02.2023)
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Unexpected failure rates for modular assembly of engineered zinc fingers
Joung, J Keith, Ramirez, Cherie L, Foley, Jonathan E, Wright, David A, Müller-Lerch, Felix, Rahman, Shamim H, Cornu, Tatjana I, Winfrey, Ronnie J, Sander, Jeffry D, Fu, Fengli, Townsend, Jeffrey A, Cathomen, Toni, Voytas, Daniel F
Published in Nature methods (01.05.2008)
Published in Nature methods (01.05.2008)
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CRISPR-Cas12a for Highly Efficient and Marker-Free Targeted Integration in Human Pluripotent Stem Cells
Hammad, Ruba, Alzubi, Jamal, Rhiel, Manuel, Chmielewski, Kay O, Mosti, Laura, Rositzka, Julia, Heugel, Marcel, Lawrenz, Jan, Pennucci, Valentina, Gläser, Birgitta, Fischer, Judith, Schambach, Axel, Moritz, Thomas, Lachmann, Nico, Cornu, Tatjana I, Mussolino, Claudio, Schäfer, Richard, Cathomen, Toni
Published in International journal of molecular sciences (01.01.2024)
Published in International journal of molecular sciences (01.01.2024)
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Automated generation of gene-edited CAR T cells at clinical scale
Alzubi, Jamal, Lock, Dominik, Rhiel, Manuel, Schmitz, Sabrina, Wild, Stefan, Mussolino, Claudio, Hildenbeutel, Markus, Brandes, Caroline, Rositzka, Julia, Lennartz, Simon, Haas, Simone A., Chmielewski, Kay O., Schaser, Thomas, Kaiser, Andrew, Cathomen, Toni, Cornu, Tatjana I.
Published in Molecular therapy. Methods & clinical development (12.03.2021)
Published in Molecular therapy. Methods & clinical development (12.03.2021)
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Journal Article
Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion
Söllü, Cem, Pars, Kaweh, Cornu, Tatjana I, Thibodeau-Beganny, Stacey, Maeder, Morgan L, Joung, J Keith, Heilbronn, Regine, Cathomen, Toni
Published in Nucleic acids research (01.12.2010)
Published in Nucleic acids research (01.12.2010)
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Cell-Based Models of 'Cytokine Release Syndrome' Endorse CD40L and Granulocyte-Macrophage Colony-Stimulating Factor Knockout in Chimeric Antigen Receptor T Cells as Mitigation Strategy
Dibas, Ala, Rhiel, Manuel, Patel, Vidisha Bhavesh, Andrieux, Geoffroy, Boerries, Melanie, Cornu, Tatjana I, Alzubi, Jamal, Cathomen, Toni
Published in Cells (Basel, Switzerland) (01.11.2023)
Published in Cells (Basel, Switzerland) (01.11.2023)
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Allele-Specific Disruption of a Common STAT3 Autosomal Dominant Allele Is Not Sufficient to Restore Downstream Signaling in Patient-Derived T Cells
König, Saskia, Fliegauf, Manfred, Rhiel, Manuel, Grimbacher, Bodo, Cornu, Tatjana I., Cathomen, Toni, Mussolino, Claudio
Published in Genes (20.10.2022)
Published in Genes (20.10.2022)
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Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq
Turchiano, Giandomenico, Andrieux, Geoffroy, Klermund, Julia, Blattner, Georges, Pennucci, Valentina, el Gaz, Melina, Monaco, Gianni, Poddar, Sushmita, Mussolino, Claudio, Cornu, Tatjana I., Boerries, Melanie, Cathomen, Toni
Published in Cell stem cell (03.06.2021)
Published in Cell stem cell (03.06.2021)
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Designer epigenome modifiers enable robust and sustained gene silencing in clinically relevant human cells
Mlambo, Tafadzwa, Nitsch, Sandra, Hildenbeutel, Markus, Romito, Marianna, Müller, Maximilian, Bossen, Claudia, Diederichs, Sven, Cornu, Tatjana I, Cathomen, Toni, Mussolino, Claudio
Published in Nucleic acids research (18.05.2018)
Published in Nucleic acids research (18.05.2018)
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Journal Article
On- and off-target effects of paired CRISPR-Cas nickase in primary human cells
Klermund, Julia, Rhiel, Manuel, Kocher, Thomas, Chmielewski, Kay Ole, Bischof, Johannes, Andrieux, Geoffroy, el Gaz, Melina, Hainzl, Stefan, Boerries, Melanie, Cornu, Tatjana I., Koller, Ulrich, Cathomen, Toni
Published in Molecular therapy (01.05.2024)
Published in Molecular therapy (01.05.2024)
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Journal Article
HIV Gene Therapy: An Update
Cornu, Tatjana I, Mussolino, Claudio, Müller, Matthias C, Wehr, Claudia, Kern, Winfried V, Cathomen, Toni
Published in Human gene therapy (01.01.2021)
Published in Human gene therapy (01.01.2021)
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Gene editing of hematopoietic stem cells restores T-cell response in familial hemophagocytic lymphohistiocytosis
Dettmer-Monaco, Viviane, Weißert, Kristoffer, Ammann, Sandra, Monaco, Gianni, Lei, Lei, Gräßel, Linda, Rhiel, Manuel, Rositzka, Julia, Kaufmann, Masako M, Geiger, Kerstin, Andrieux, Geoffroy, Lao, Jessica, Thoulass, Gudrun, Schell, Christoph, Boerries, Melanie, Illert, Anna L, Cornu, Tatjana I, Ehl, Stephan, Aichele, Peter, Cathomen, Toni
Published in Journal of allergy and clinical immunology (01.01.2024)
Published in Journal of allergy and clinical immunology (01.01.2024)
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