Pharmacokinetic Properties of Mirabegron, a β3 -Adrenoceptor Agonist: Results From Two Phase I, Randomized, Multiple-Dose Studies in Healthy Young and Elderly Men and Women
Krauwinkel, Walter, MSc, van Dijk, Jan, BSc, Schaddelee, Marloes, PhD, Eltink, Charlotte, MSc, Meijer, John, MSc, Strabach, Grégory, MD, van Marle, Sjoerd, MD, Kerbusch, Virginie, PhD, van Gelderen, Marcel, PhD
Published in Clinical therapeutics (01.10.2012)
Published in Clinical therapeutics (01.10.2012)
Get full text
Journal Article
Safety and Pharmacokinetics of Intravenous and Oral Fosmanogepix, a First-in-Class Antifungal Agent, in Healthy Volunteers
Hodges, Michael R, Ople, Eric, Wedel, Pamela, Shaw, Karen J, Jakate, Abhijeet, Kramer, William G, Marle, Sjoerd van, van Hoogdalem, Ewoud-Jan, Tawadrous, Margaret
Published in Antimicrobial agents and chemotherapy (18.04.2023)
Published in Antimicrobial agents and chemotherapy (18.04.2023)
Get full text
Journal Article
Absorption, metabolism, and excretion of intravenously and orally administered [14C]telmisartan in healthy volunteers
Stangier, J, Schmid, J, Türck, D, Switek, H, Verhagen, A, Peeters, P A, van Marle, S P, Tamminga, W J, Sollie, F A, Jonkman, J H
Published in Journal of clinical pharmacology (01.12.2000)
Published in Journal of clinical pharmacology (01.12.2000)
Get more information
Journal Article
Multiple-dose pharmacokinetics, safety, and tolerability of bosentan, an endothelin receptor antagonist, in healthy male volunteers
Weber, C, Schmitt, R, Birnboeck, H, Hopfgartner, G, Eggers, H, Meyer, J, van Marle, S, Viischer, H W, Jonkman, J H
Published in Journal of clinical pharmacology (01.07.1999)
Published in Journal of clinical pharmacology (01.07.1999)
Get more information
Journal Article
Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects
Weber, C, Schmitt, R, Birnboeck, H, Hopfgartner, G, van Marle, S P, Peeters, P A, Jonkman, J H, Jones, C R
Published in Clinical pharmacology and therapeutics (01.08.1996)
Published in Clinical pharmacology and therapeutics (01.08.1996)
Get more information
Journal Article
Pharmacokinetics, safety, and tolerability of fosmanogepix IV to oral switch and multiple IV doses in healthy participants
Hodges, Michael R, Hazel, Susan, Kramer, William G, van Hoogdalem, Ewoud-Jan, van Marle, Sjoerd, Tawadrous, Margaret, Jakate, Abhijeet
Published in Antimicrobial agents and chemotherapy (02.05.2024)
Published in Antimicrobial agents and chemotherapy (02.05.2024)
Get full text
Journal Article
Metabolism and Disposition of Siponimod, a Novel Selective S1P 1 /S1P 5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
Glaenzel, Ulrike, Jin, Yi, Nufer, Robert, Li, Wenkui, Schroer, Kirsten, Adam-Stitah, Sylvie, Peter van Marle, Sjoerd, Legangneux, Eric, Borell, Hubert, James, Alexander D, Meissner, Axel, Camenisch, Gian, Gardin, Anne
Published in Drug metabolism and disposition (01.07.2018)
Published in Drug metabolism and disposition (01.07.2018)
Get full text
Journal Article
Single dose pharmacokinetics and absolute bioavailability of mirabegron, a β₃-adrenoceptor agonist for treatment of overactive bladder
Eltink, Charlotte, Lee, Jennifer, Schaddelee, Marloes, Zhang, Wenhui, Kerbusch, Virginie, Meijer, John, van Marle, Sjoerd, Grunenberg, Nicole, Kowalski, Donna, Drogendijk, Ted, Moy, Selina, Iitsuka, Hiromi, van Gelderen, Marcel, Matsushima, Hiroshi, Sawamoto, Taiji
Published in International journal of clinical pharmacology and therapeutics (01.11.2012)
Published in International journal of clinical pharmacology and therapeutics (01.11.2012)
Get more information
Journal Article
Absorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans
Hashimoto, Tadashi, Suzuki, Katsuhiro, Kihara, Yukie, Iwatsubo, Takafumi, Miyashita, Aiji, Heeringa, Marten, Onkels, Hartmut, Groenendaal, Dorien, Verheggen, Frank, van Marle, Sjoerd, Usui, Takashi
Published in Xenobiotica (01.06.2013)
Published in Xenobiotica (01.06.2013)
Get full text
Journal Article
Pharmacokinetic Characterization of the Novel Pulmonary Delivery Excipient Fumaryl Diketopiperazine
Potocka, Elizabeth, Cassidy, James P., Haworth, Pamela, Heuman, Douglas, van Marle, Sjoerd, Baughman, Robert A.
Published in Journal of diabetes science and technology (01.09.2010)
Published in Journal of diabetes science and technology (01.09.2010)
Get full text
Journal Article
Sugammadex is cleared rapidly and primarily unchanged via renal excretion
Peeters, Pierre, Passier, Paul, Smeets, Jean, Zwiers, Alex, de Zwart, Marcel, van de Wetering-Krebbers, Saskia, van Iersel, Marlou, van Marle, Sjoerd, van den Dobbelsteen, Diels
Published in Biopharmaceutics & drug disposition (01.04.2011)
Published in Biopharmaceutics & drug disposition (01.04.2011)
Get full text
Journal Article
Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study
Cahn, Anthony, Hodgson, Simon, Wilson, Robert, Robertson, Jonathan, Watson, Joanna, Beerahee, Misba, Hughes, Steve C, Young, Graeme, Graves, Rebecca, Hall, David, van Marle, Sjoerd, Solari, Roberto
Published in BMC pharmacology & toxicology (28.02.2013)
Published in BMC pharmacology & toxicology (28.02.2013)
Get full text
Journal Article