A novel Cas9 fusion protein promotes targeted genome editing with reduced mutational burden in primary human cells
Carusillo, Antonio, Haider, Sibtain, Schäfer, Raul, Rhiel, Manuel, Türk, Daniel, Chmielewski, Kay O, Klermund, Julia, Mosti, Laura, Andrieux, Geoffroy, Schäfer, Richard, Cornu, Tatjana I, Cathomen, Toni, Mussolino, Claudio
Published in Nucleic acids research (22.05.2023)
Published in Nucleic acids research (22.05.2023)
Get full text
Journal Article
Unexpected failure rates for modular assembly of engineered zinc fingers
Joung, J Keith, Ramirez, Cherie L, Foley, Jonathan E, Wright, David A, Müller-Lerch, Felix, Rahman, Shamim H, Cornu, Tatjana I, Winfrey, Ronnie J, Sander, Jeffry D, Fu, Fengli, Townsend, Jeffrey A, Cathomen, Toni, Voytas, Daniel F
Published in Nature methods (01.05.2008)
Published in Nature methods (01.05.2008)
Get full text
Journal Article
Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion
Söllü, Cem, Pars, Kaweh, Cornu, Tatjana I, Thibodeau-Beganny, Stacey, Maeder, Morgan L, Joung, J Keith, Heilbronn, Regine, Cathomen, Toni
Published in Nucleic acids research (01.12.2010)
Published in Nucleic acids research (01.12.2010)
Get full text
Journal Article
Cell-Based Models of 'Cytokine Release Syndrome' Endorse CD40L and Granulocyte-Macrophage Colony-Stimulating Factor Knockout in Chimeric Antigen Receptor T Cells as Mitigation Strategy
Dibas, Ala, Rhiel, Manuel, Patel, Vidisha Bhavesh, Andrieux, Geoffroy, Boerries, Melanie, Cornu, Tatjana I, Alzubi, Jamal, Cathomen, Toni
Published in Cells (Basel, Switzerland) (01.11.2023)
Published in Cells (Basel, Switzerland) (01.11.2023)
Get full text
Journal Article
HIV Gene Therapy: An Update
Cornu, Tatjana I, Mussolino, Claudio, Müller, Matthias C, Wehr, Claudia, Kern, Winfried V, Cathomen, Toni
Published in Human gene therapy (01.01.2021)
Published in Human gene therapy (01.01.2021)
Get more information
Journal Article
Gene editing of hematopoietic stem cells restores T-cell response in familial hemophagocytic lymphohistiocytosis
Dettmer-Monaco, Viviane, Weißert, Kristoffer, Ammann, Sandra, Monaco, Gianni, Lei, Lei, Gräßel, Linda, Rhiel, Manuel, Rositzka, Julia, Kaufmann, Masako M, Geiger, Kerstin, Andrieux, Geoffroy, Lao, Jessica, Thoulass, Gudrun, Schell, Christoph, Boerries, Melanie, Illert, Anna L, Cornu, Tatjana I, Ehl, Stephan, Aichele, Peter, Cathomen, Toni
Published in Journal of allergy and clinical immunology (01.01.2024)
Published in Journal of allergy and clinical immunology (01.01.2024)
Get full text
Journal Article
Biodegradable Nanocarriers Resembling Extracellular Vesicles Deliver Genetic Material with the Highest Efficiency to Various Cell Types
Tarakanchikova, Yana, Alzubi, Jamal, Pennucci, Valentina, Follo, Marie, Kochergin, Boris, Muslimov, Albert, Skovorodkin, Ilya, Vainio, Seppo, Antipina, Maria N., Atkin, Vsevolod, Popov, Alexey, Meglinski, Igor, Cathomen, Toni, Cornu, Tatjana I., Gorin, Dmitry A., Sukhorukov, Gleb B., Nazarenko, Irina
Published in Small (Weinheim an der Bergstrasse, Germany) (01.01.2020)
Published in Small (Weinheim an der Bergstrasse, Germany) (01.01.2020)
Get full text
Journal Article
Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy
Marone, Romina, Landmann, Emmanuelle, Devaux, Anna, Lepore, Rosalba, Seyres, Denis, Zuin, Jessica, Burgold, Thomas, Engdahl, Corinne, Capoferri, Giuseppina, Dell'Aglio, Alessandro, Larrue, Clément, Simonetta, Federico, Rositzka, Julia, Rhiel, Manuel, Andrieux, Geoffroy, Gallagher, Danielle N, Schröder, Markus S, Wiederkehr, Amélie, Sinopoli, Alessandro, Do Sacramento, Valentin, Haydn, Anna, Garcia-Prat, Laura, Divsalar, Christopher, Camus, Anna, Xu, Liwen, Bordoli, Lorenza, Schwede, Torsten, Porteus, Matthew, Tamburini, Jérôme, Corn, Jacob E, Cathomen, Toni, Cornu, Tatjana I, Urlinger, Stefanie, Jeker, Lukas T
Published in The Journal of experimental medicine (04.12.2023)
Published in The Journal of experimental medicine (04.12.2023)
Get full text
Journal Article
Cells Expressing the RING Finger Z Protein Are Resistant to Arenavirus Infection
CORNU, Tatiana I, FELDMANN, Heinz, DE LA TORRE, Juan Carlos
Published in Journal of Virology (01.03.2004)
Published in Journal of Virology (01.03.2004)
Get full text
Journal Article
Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing
Knipping, Friederike, Newby, Gregory A., Eide, Cindy R., McElroy, Amber N., Nielsen, Sarah C., Smith, Kyle, Fang, Yongxing, Cornu, Tatjana I., Costa, Caroline, Gutierrez-Guerrero, Alejandra, Bingea, Samuel P., Feser, Colby J., Steinbeck, Benjamin, Hippen, Keli L., Blazar, Bruce R., McCaffrey, Anton, Mussolino, Claudio, Verhoeyen, Els, Tolar, Jakub, Liu, David R., Osborn, Mark J.
Published in Molecular therapy (05.01.2022)
Published in Molecular therapy (05.01.2022)
Get full text
Journal Article
Preclinical Evaluation of a Novel TALEN Targeting CCR5 Confirms Efficacy and Safety in Conferring Resistance to HIV‐1 Infection
Romito, Marianna, Juillerat, Alexandre, Kok, Yik Lim, Hildenbeutel, Markus, Rhiel, Manuel, Andrieux, Geoffroy, Geiger, Johannes, Rudolph, Carsten, Mussolino, Claudio, Duclert, Aymeric, Metzner, Karin J., Duchateau, Philippe, Cathomen, Toni, Cornu, Tatjana I.
Published in Biotechnology journal (01.01.2021)
Published in Biotechnology journal (01.01.2021)
Get full text
Journal Article
Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect
Kögl, Tamara, Chang, Hsin-Fang, Staniek, Julian, Chiang, Samuel C C, Thoulass, Gudrun, Lao, Jessica, Weißert, Kristoffer, Dettmer-Monaco, Viviane, Geiger, Kerstin, Manna, Paul T, Beziat, Vivien, Momenilandi, Mana, Tu, Szu-Min, Keppler, Selina J, Pattu, Varsha, Wolf, Philipp, Kupferschmid, Laurence, Tholen, Stefan, Covill, Laura E, Ebert, Karolina, Straub, Tobias, Groß, Miriam, Gather, Ruth, Engel, Helena, Salzer, Ulrich, Schell, Christoph, Maier, Sarah, Lehmberg, Kai, Cornu, Tatjana I, Pircher, Hanspeter, Shahrooei, Mohammad, Parvaneh, Nima, Elling, Roland, Rizzi, Marta, Bryceson, Yenan T, Ehl, Stephan, Aichele, Peter, Ammann, Sandra
Published in The Journal of experimental medicine (01.07.2024)
Published in The Journal of experimental medicine (01.07.2024)
Get full text
Journal Article
Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors
Händel, Eva-Maria, Gellhaus, Katharina, Khan, Kafaitullah, Bednarski, Christien, Cornu, Tatjana I, Müller-Lerch, Felix, Kotin, Robert M, Heilbronn, Regine, Cathomen, Toni
Published in Human gene therapy (01.03.2012)
Published in Human gene therapy (01.03.2012)
Get more information
Journal Article
Safe and effective liver-directed AAV-mediated homology-independent targeted integration in mouse models of inherited diseases
Esposito, Federica, Dell’Aquila, Fabio, Rhiel, Manuel, Auricchio, Stefano, Chmielewski, Kay Ole, Andrieux, Geoffroy, Ferla, Rita, Horrach, Paula Sureda, Padmanabhan, Arjun, Di Cunto, Roberto, Notaro, Simone, Santeularia, Manel Llado, Boerries, Melanie, Dell’Anno, Margherita, Nusco, Edoardo, Padula, Agnese, Nutarelli, Sofia, Cornu, Tatjana I., Sorrentino, Nicolina Cristina, Piccolo, Pasquale, Trapani, Ivana, Cathomen, Toni, Auricchio, Alberto
Published in Cell reports. Medicine (16.07.2024)
Published in Cell reports. Medicine (16.07.2024)
Get full text
Journal Article