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Published in Journal of the American Chemical Society (06.02.2002)
Published in Journal of the American Chemical Society (06.02.2002)
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3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts
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Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Synthesis of Cyclooctenones Using Intramolecular Hydroacylation
Aloise, Allen D, Layton, Mark E, Shair, Matthew D
Published in Journal of the American Chemical Society (20.12.2000)
Published in Journal of the American Chemical Society (20.12.2000)
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Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis
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Published in Bioorganic & medicinal chemistry letters (15.02.2016)
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
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Synthesis of (+)-CP-263,114
Chen, Chuo, Layton, Mark E, Sheehan, Scott M, Shair, Matthew D
Published in Journal of the American Chemical Society (02.08.2000)
Published in Journal of the American Chemical Society (02.08.2000)
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2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS
JASON M COX, CHRISTOPHER JAMES BUNGARD, LIU JIAN, MICHAEL J KELLY III, JAMES J PERKINS, AKSHAY A SHAH, IAN M BELL, LIU HONG, CHRISTOPHER S BURGEY, MARK E LAYTON, WU ZHE, ASHOK ARASAPPAN, MICHAEL DAVID VANHEYST
Year of Publication 03.10.2023
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Year of Publication 03.10.2023
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2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS
JASON M COX, CHRISTOPHER JAMES BUNGARD, LIU JIAN, MICHAEL J KELLY III, JAMES J PERKINS, AKSHAY A SHAH, IAN M BELL, LIU HONG, CHRISTOPHER S BURGEY, MARK E LAYTON, WU ZHE, ASHOK ARASAPPAN, MICHAEL DAVID VANHEYST
Year of Publication 04.07.2023
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Year of Publication 04.07.2023
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Stereospecific Synthesis of the CP-263,114 Core Structure
Chen, Chuo, Layton, Mark E, Shair, Matthew D
Published in Journal of the American Chemical Society (21.10.1998)
Published in Journal of the American Chemical Society (21.10.1998)
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Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na(v)1.7 inhibitors with pain efficacy in mice
Roecker, Anthony J., Egbertson, Melissa, Jones, Kristen L. G., Gomez, Robert, Kraus, Richard L., Li, Yuxing, Koser, Amy Jo, Urban, Mark O., Klein, Rebecca, Clements, Michelle, Panigel, Jacqueline, Daley, Christopher, Wang, Jixin, Finger, Eleftheria N., Majercak, John, Santarelli, Vincent, Gregan, Irene, Cato, Matthew, Filzen, Tracey, Jovanovska, Aneta, Wang, Ying-Hong, Wang, Deping, Joyce, Leo A., Sherer, Edward C., Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Coleman, Paul J., Houghton, Andrea K., Layton, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
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Benzoxazolinone aryl sulfonamides as potent, selective Na(v)1.7 inhibitors with in vivo efficacy in a preclinical pain model
Pero, Joseph E., Rossi, Michael A., Lehman, Hannah D. G. F., Kelly, Michael J., Mulhearn, James J., Wolkenberg, Scott E., Cato, Matthew J., Clements, Michelle K., Daley, Christopher J., Filzen, Tracey, Finger, Eleftheria N., Gregan, Yun, Henze, Darrell A., Jovanovska, Aneta, Klein, Rebecca, Kraus, Richard L., Li, Yuxing, Liang, Annie, Majercak, John M., Panigel, Jacqueline, Urban, Mark O., Wang, Jixin, Wang, Ying-Hong, Houghton, Andrea K., Layton, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
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PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION
MCCAULEY, John A, ACTON, III, DE LERA RUIZ, Manuel, PARISH, Craig, ROECKER, Anthony J, MORRIELLO, Gregori J, KLINGLER, Franca-Maria, GUPTA, Mayuri, KRISHNAMURTHY, Harini, KELLY III, Michael J, SHURTLEFF, Valerie W, LAYTON, Mark E, PERKINS, James
Year of Publication 18.07.2024
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Year of Publication 18.07.2024
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5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS
Liu, Jian, Layton, Mark E, Cox, Jason Michael, Shah, Akshay A, VanHeyst, Michael David, Bell, Ian M, Kelly, III, Michael J, Arasappan, Ashok, Liu, Hong
Year of Publication 20.07.2023
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Year of Publication 20.07.2023
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DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS
GUO, Liangqin, ZHANG, Ting, WON, Walter, BURGEY, Christopher, S, STELMACH, John, E, GRESHOCK, Thomas, J, ROECKER, Anthony, J, WANG, Deping, LAYTON, Mark, E, NANTERMET, Philippe, G, MULHEARN, James, J, ANAND, Rajan, KIM, Ronald, M, JIAN, Tianying, ZHOU, Gang
Year of Publication 01.11.2023
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Year of Publication 01.11.2023
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