Alzheimer's Disease: From Pathology to Therapeutic Approaches
Jakob-Roetne, Roland, Jacobsen, Helmut
Published in Angewandte Chemie (International ed.) (14.04.2009)
Published in Angewandte Chemie (International ed.) (14.04.2009)
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Journal Article
Molecular Recognition at the Active Site of Catechol-O-Methyltransferase: Energetically Favorable Replacement of a Water Molecule Imported by a Bisubstrate Inhibitor
Ellermann, Manuel, Jakob-Roetne, Roland, Lerner, Christian, Borroni, Edilio, Schlatter, Daniel, Roth, Doris, Ehler, Andreas, Rudolph, Markus Georg, Diederich, François
Published in Angewandte Chemie (International ed.) (01.01.2009)
Published in Angewandte Chemie (International ed.) (01.01.2009)
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Journal Article
Molecular Recognition at the Active Site of Catechol-O-methyltransferase (COMT): Adenine Replacements in Bisubstrate Inhibitors
Ellermann, Manuel, Paulini, Ralph, Jakob-Roetne, Roland, Lerner, Christian, Borroni, Edilio, Roth, Doris, Ehler, Andreas, Schweizer, W. Bernd, Schlatter, Daniel, Rudolph, Markus G., Diederich, François
Published in Chemistry : a European journal (27.05.2011)
Published in Chemistry : a European journal (27.05.2011)
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Journal Article
X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity
Lerner, Christian, Ruf, Armin, Gramlich, Volker, Masjost, Birgit, Zürcher, Gerhard, Jakob-Roetne, Roland, Borroni, Edilio, Diederich, François
Published in Angewandte Chemie (International ed.) (05.11.2001)
Published in Angewandte Chemie (International ed.) (05.11.2001)
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Journal Article
Synthesis and Biological Evaluation of Potent Bisubstrate Inhibitors of the Enzyme Catechol O-Methyltransferase (COMT) Lacking a Nitro Group
Paulini, Ralph, Lerner, Christian, Diederich, François, Jakob-Roetne, Roland, Zürcher, Gerhard, Borroni, Edilio
Published in Helvetica chimica acta (01.09.2006)
Published in Helvetica chimica acta (01.09.2006)
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Journal Article
Structure-Based Design, Synthesis, and in vitro Evaluation of Bisubstrate Inhibitors for Catechol O-Methyltransferase (COMT)
Masjost, Birgit, Ballmer, Patrick, Borroni, Edilio, Zürcher, Gerhard, Winkler, Fritz K., Jakob-Roetne, Roland, Diederich, François
Published in Chemistry : a European journal (17.03.2000)
Published in Chemistry : a European journal (17.03.2000)
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Journal Article
Bisubstrate Inhibitors for the Enzyme Catechol O-Methyltransferase (COMT): Dramatic Effects of Ribose Modifications on Binding Affinity and Binding Mode
Lerner, Christian, Siegrist, Romain, Schweizer, Eliane, Diederich, François, Gramlich, Volker, Jakob-Roetne, Roland, Zürcher, Gerhard, Borroni, Edilio
Published in Helvetica chimica acta (01.04.2003)
Published in Helvetica chimica acta (01.04.2003)
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Journal Article
derivados de isoxazol-piridina, seu uso e procesos de preparação e medicamento
Henner Knust, Bernd Buettelmann, Matthew C. Lucas, Andrew Thomas, Roland Jakob-Roetne
Year of Publication 15.01.2019
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Year of Publication 15.01.2019
Patent
derivados de isoxazol-isoxazol e isoxazol-isotiazol
Maria-Clemencia Hernandez, MATTHEW C. LUCAS, Andrew Thomas, Roland Jakob-Roetne
Year of Publication 02.01.2018
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Year of Publication 02.01.2018
Patent
Substituted 2-oxo-azepane derivatives are potent, orally active γ-secretase inhibitors
Kitas, Eric A., Galley, Guido, Jakob-Roetne, Roland, Flohr, Alexander, Wostl, Wolfgang, Mauser, Harald, Alker, André M., Czech, Christian, Ozmen, Laurence, David-Pierson, Pascale, Reinhardt, Dieter, Jacobsen, Helmut
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article