Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure-based drug design
O'Brien, Alistair, Andrews, Stephen P., Baig, Asma H., Bortolato, Andrea, Brown, Alastair J.H., Brown, Giles A., Brown, Sue H., Christopher, John A., Congreve, Miles, Cooke, Robert M., De Graaf, Chris, Errey, James C., Fieldhouse, Charlotte, Jazayeri, Ali, Marshall, Fiona H., Mason, Jonathan S., Mobarec, Juan Carlos, Okrasa, Krzysztof, Steele, Kelly N., Southall, Stacey M., Teobald, Iryna, Watson, Steve P., Weir, Malcolm
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
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Journal Article
Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target
Brown, Dean G., Brown, Giles A., Centrella, Paolo, Certel, Kaan, Cooke, Robert M., Cuozzo, John W., Dekker, Niek, Dumelin, Christoph E., Ferguson, Andrew, Fiez-Vandal, Cédric, Geschwindner, Stefan, Guié, Marie-Aude, Habeshian, Sevan, Keefe, Anthony D., Schlenker, Oliver, Sigel, Eric A., Snijder, Arjan, Soutter, Holly T., Sundström, Linda, Troast, Dawn M., Wiggin, Giselle, Zhang, Jing, Zhang, Ying, Clark, Matthew A.
Published in SLAS discovery (01.06.2018)
Published in SLAS discovery (01.06.2018)
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Journal Article
Sequenced Reactions with Samarium(II) Iodide. Sequential Intramolecular Reformatsky/Nucleophilic Acyl Substitution Reactions for the Synthesis of Medium-Sized Carbocycles
Molander, Gary A, Brown, Giles A, Storch de Gracia, Isabel
Published in Journal of organic chemistry (17.05.2002)
Published in Journal of organic chemistry (17.05.2002)
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Journal Article
Aldehydes and ketones as dipolarophiles: application to the synthesis of oxapenams
Andrews, MD, Brown, GA, Charmant, JPH, Peakman, TM, Rebello, A, Walsh, KE, Gallagher, T, Hales, NJ
Published in Chemical communications (Cambridge, England) (07.02.1999)
Published in Chemical communications (Cambridge, England) (07.02.1999)
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Journal Article
Trapping highly reactive dipolarophiles. Exploiting the mechanism associated with the azomethine ylide strategy for beta-lactam synthesis
Brown, GA, Anderson, KM, Large, JM, Planchenault, D, Urban, D, Hales, NJ, Gallagher, T
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (2001)
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (2001)
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Journal Article
The azomethine ylide strategy for beta-lactam synthesis. An evaluation of alternative pathways for azomethine ylide generation
Brown, GA, Martel, Wisedale, R, Charmant, JPH, Hales, NJ, Fishwick, CWG, Gallagher, T
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (01.01.2001)
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (01.01.2001)
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Journal Article
The azomethine ylide strategy for beta-lactam synthesis. A comprehensive mechanistic evaluation
Brown, D, Brown, GA, Martel, Planchenault, D, Turmes, E, Walsh, KE, Wisedale, R, Hales, NJ, Fishwick, CWG, Gallagher, T
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (01.01.2001)
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (01.01.2001)
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Journal Article
CXCR4 RECEPTOR ANTAGONISTS
GILES BROWN, KATHRYN OLIVER, LEE PATIENT, ALISON STEWART, ANDREW GRAHAM COLE, IAIN SIMPSON, ALISON CARLEY, MICHAEL HIGGINBOTTOM, EDWARD DANIEL SAVORY
Year of Publication 03.03.2016
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Year of Publication 03.03.2016
Patent
CYCLIC APELIN RECEPTOR AGONISTS
SCULLY, Conor, BROWN, Giles Albert, PAUL, Rebecca, CONGREVE, Miles Stuart
Year of Publication 30.11.2023
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Year of Publication 30.11.2023
Patent