The importance of synthetic chemistry in the pharmaceutical industry
Campos, Kevin R, Coleman, Paul J, Alvarez, Juan C, Dreher, Spencer D, Garbaccio, Robert M, Terrett, Nicholas K, Tillyer, Richard D, Truppo, Matthew D, Parmee, Emma R
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Published in Science (American Association for the Advancement of Science) (18.01.2019)
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Concise Asymmetric Syntheses of Radicicol and Monocillin I
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Published in Journal of the American Chemical Society (07.11.2001)
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3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts
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Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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CC-1065 and the Duocarmycins: Synthetic Studies
Boger, Dale L, Boyce, Christopher W, Garbaccio, Robert M, Goldberg, Joel A
Published in Chemical reviews (08.05.1997)
Published in Chemical reviews (08.05.1997)
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Total Synthesis as a Resource in the Discovery of Potentially Valuable Antitumor Agents: Cycloproparadicicol
Yamamoto, Kana, Garbaccio, Robert M., Stachel, Shawn J., Solit, David B., Chiosis, Gabriela, Rosen, Neal, Danishefsky, Samuel J.
Published in Angewandte Chemie (International ed.) (17.03.2003)
Published in Angewandte Chemie (International ed.) (17.03.2003)
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Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs
Kern, Jeffrey C., Dooney, Deborah, Zhang, Rena, Liang, Linda, Brandish, Philip E., Cheng, Mangeng, Feng, Guo, Beck, Andrew, Bresson, Damien, Firdos, Juhi, Gately, Dennis, Knudsen, Nick, Manibusan, Anthony, Sun, Ying, Garbaccio, Robert M.
Published in Bioconjugate chemistry (21.09.2016)
Published in Bioconjugate chemistry (21.09.2016)
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Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-Coil Domain Truncations
Brown, Zachary Z, Mapelli, Claudio, Farasat, Iman, Shoultz, Alycia V, Johnson, Scott A, Orvieto, Federica, Santoprete, Alessia, Bianchi, Elisabetta, McCracken, Amy Bittner, Chen, Kuanchang, Zhu, Xiaohong, Demma, Mark J, Lacey, Brian M, Canada, Keith A, Garbaccio, Robert M, O’Neil, Jennifer, Walji, Abbas
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Published in Journal of organic chemistry (07.02.2020)
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Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP
Garbaccio, Robert M., Tasber, Edward S., Neilson, Lou Anne, Coleman, Paul J., Fraley, Mark E., Olson, Christy, Bergman, Jeff, Torrent, Maricel, Buser, Carolyn A., Rickert, Keith, Walsh, Eileen S., Hamilton, Kelly, Lobell, Robert B., Tao, Weikang, South, Vicki J., Diehl, Ronald E., Davide, Joseph P., Yan, Youwei, Kuo, Lawrence C., Li, Chunze, Prueksaritanont, Thomayant, Fernandez-Metzler, Carmen, Mahan, Elizabeth A., Slaughter, Donald E., Salata, Joseph J., Kohl, Nancy E., Huber, Hans E., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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Endosomolytic Bioreducible Poly(amido amine disulfide) Polymer Conjugates for the in Vivo Systemic Delivery of siRNA Therapeutics
Parmar, Rubina Giare, Busuek, Marina, Walsh, Eileen S, Leander, Karen R, Howell, Bonnie J, Sepp-Lorenzino, Laura, Kemp, Eric, Crocker, Louis S, Leone, Anthony, Kochansky, Christopher J, Carr, Brian A, Garbaccio, Robert M, Colletti, Steven L, Wang, Weimin
Published in Bioconjugate chemistry (17.04.2013)
Published in Bioconjugate chemistry (17.04.2013)
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Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates
Barrett, Stephanie E., Burke, Rob S., Abrams, Marc T., Bason, Carol, Busuek, Marina, Carlini, Edward, Carr, Brian A., Crocker, Louis S., Fan, Haihong, Garbaccio, Robert M., Guidry, Erin N., Heo, Jun H., Howell, Bonnie J., Kemp, Eric A., Kowtoniuk, Robert A., Latham, Andrew H., Leone, Anthony M., Lyman, Michael, Parmar, Rubina G., Patel, Mihir, Pechenov, Sergey Y., Pei, Tao, Pudvah, Nicole T., Raab, Conrad, Riley, Sean, Sepp-Lorenzino, Laura, Smith, Sheri, Soli, Eric D., Staskiewicz, Steven, Stern, Melissa, Truong, Quang, Vavrek, Marissa, Waldman, Jacob H., Walsh, Eileen S., Williams, J. Michael, Young, Stephanie, Colletti, Steven L.
Published in Journal of controlled release (10.06.2014)
Published in Journal of controlled release (10.06.2014)
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Development of thioquinazolinones, allosteric Chk1 kinase inhibitors
Converso, Antonella, Hartingh, Timothy, Garbaccio, Robert M., Tasber, Edward, Rickert, Keith, Fraley, Mark E., Yan, Youwei, Kreatsoulas, Constantine, Stirdivant, Steve, Drakas, Bob, Walsh, Eileen S., Hamilton, Kelly, Buser, Carolyn A., Mao, Xianzhi, Abrams, Marc T., Beck, Stephen C., Tao, Weikang, Lobell, Rob, Sepp-Lorenzino, Laura, Zugay-Murphy, Joan, Sardana, Vinod, Munshi, Sanjeev K., Jezequel-Sur, Sylvie Marie, Zuck, Paul D., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
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Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase
Converso, Antonella, Hartingh, Timothy, Fraley, Mark E., Garbaccio, Robert M., Hartman, George D., Huang, Shaei Y., Majercak, John M., McCampbell, Alexander, Na, Sang Jin, Ray, William J., Savage, Mary J., Wolffe, Carrie, Yeh, Suzie, Yu, Yuanjiang, White, Rebecca, Zhang, Rena
Published in Bioorganic & medicinal chemistry letters (15.06.2014)
Published in Bioorganic & medicinal chemistry letters (15.06.2014)
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Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis
Layton, Mark E., Reif, Alexander J., Hartingh, Timothy J., Rodzinak, Kevin, Dudkin, Vadim, Wang, Cheng, Arrington, Ken, Kelly, Michael J., Garbaccio, Robert M., O’Brien, Julie A., Magliaro, Brian C., Uslaner, Jason M., Huszar, Sarah L., Fillgrove, Kerry L., Tang, Cuyue, Kuo, Yuhsin, Jacobson, Marlene A.
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
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Improving the In Vivo Therapeutic Index of siRNA Polymer Conjugates through Increasing pH Responsiveness
Guidry, Erin N, Farand, Julie, Soheili, Arash, Parish, Craig A, Kevin, Nancy J, Pipik, Brenda, Calati, Kathleen B, Ikemoto, Nori, Waldman, Jacob H, Latham, Andrew H, Howell, Bonnie J, Leone, Anthony, Garbaccio, Robert M, Barrett, Stephanie E, Parmar, Rubina Giare, Truong, Quang T, Mao, Bing, Davies, Ian W, Colletti, Steven L, Sepp-Lorenzino, Laura
Published in Bioconjugate chemistry (19.02.2014)
Published in Bioconjugate chemistry (19.02.2014)
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Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein
Cox, Christopher D., Breslin, Michael J., Whitman, David B., Coleman, Paul J., Garbaccio, Robert M., Fraley, Mark E., Zrada, Matthew M., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Lobell, Robert B., Tao, Weikang, Abrams, Marc T., South, Vicki J., Huber, Hans E., Kohl, Nancy E., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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