The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
Nag, Suman, Trivedi, Darshan V, Sarkar, Saswata S, Adhikari, Arjun S, Sunitha, Margaret S, Sutton, Shirley, Ruppel, Kathleen M, Spudich, James A
Published in Nature structural & molecular biology (01.06.2017)
Published in Nature structural & molecular biology (01.06.2017)
Get full text
Journal Article
Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy
Ranjbarvaziri, Sara, Kooiker, Kristina B, Ellenberger, Mathew, Fajardo, Giovanni, Zhao, Mingming, Vander Roest, Alison Schroer, Woldeyes, Rahel A, Koyano, Tiffany T, Fong, Robyn, Ma, Ning, Tian, Lei, Traber, Gavin M, Chan, Frandics, Perrino, John, Reddy, Sushma, Chiu, Wah, Wu, Joseph C, Woo, Joseph Y, Ruppel, Kathleen M, Spudich, James A, Snyder, Michael P, Contrepois, Kévin, Bernstein, Daniel
Published in Circulation (New York, N.Y.) (23.11.2021)
Published in Circulation (New York, N.Y.) (23.11.2021)
Get full text
Journal Article
Cryo-EM structure of the folded-back state of human β-cardiac myosin
Grinzato, Alessandro, Auguin, Daniel, Kikuti, Carlos, Nandwani, Neha, Moussaoui, Dihia, Pathak, Divya, Kandiah, Eaazhisai, Ruppel, Kathleen M., Spudich, James A., Houdusse, Anne, Robert-Paganin, Julien
Published in Nature communications (31.05.2023)
Published in Nature communications (31.05.2023)
Get full text
Journal Article
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Nature communications (18.06.2019)
Published in Nature communications (18.06.2019)
Get full text
Journal Article
Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
Morck, Makenna M, Bhowmik, Debanjan, Pathak, Divya, Dawood, Aminah, Spudich, James, Ruppel, Kathleen M
Published in eLife (29.06.2022)
Published in eLife (29.06.2022)
Get full text
Journal Article
Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin
Sommese, Ruth F, Nag, Suman, Sutton, Shirley, Miller, Susan M, Spudich, James A, Ruppel, Kathleen M
Published in PloS one (18.12.2013)
Published in PloS one (18.12.2013)
Get full text
Journal Article
Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level
Liu, Chao, Kawana, Masataka, Song, Dan, Ruppel, Kathleen M., Spudich, James A.
Published in Nature structural & molecular biology (01.06.2018)
Published in Nature structural & molecular biology (01.06.2018)
Get full text
Journal Article
Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers
Anderson, Robert L., Trivedi, Darshan V., Sarkar, Saswata S., Henze, Marcus, Ma, Weikang, Gong, Henry, Rogers, Christopher S., Gorham, Joshua M., Wong, Fiona L., Morck, Makenna M., Seidman, Jonathan G., Ruppel, Kathleen M., Irving, Thomas C., Cooke, Roger, Green, Eric M., Spudich, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2018)
Get full text
Journal Article
Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state
Vander Roest, Alison Schroer, Liu, Chao, Morck, Makenna M, Kooiker, Kristina Bezold, Jung, Gwanghyun, Song, Dan, Dawood, Aminah, Jhingran, Arnav, Pardon, Gaspard, Ranjbarvaziri, Sara, Fajardo, Giovanni, Zhao, Mingming, Campbell, Kenneth S, Pruitt, Beth L, Spudich, James A, Ruppel, Kathleen M, Bernstein, Daniel
Published in Proceedings of the National Academy of Sciences - PNAS (15.06.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (15.06.2021)
Get full text
Journal Article
SETD3 is an actin histidine methyltransferase that prevents primary dystocia
Wilkinson, Alex W., Diep, Jonathan, Dai, Shaobo, Liu, Shuo, Ooi, Yaw Shin, Song, Dan, Li, Tie-Mei, Horton, John R., Zhang, Xing, Liu, Chao, Trivedi, Darshan V., Ruppel, Katherine M., Vilches-Moure, José G., Casey, Kerriann M., Mak, Justin, Cowan, Tina, Elias, Joshua E., Nagamine, Claude M., Spudich, James A., Cheng, Xiaodong, Carette, Jan E., Gozani, Or
Published in Nature (London) (01.01.2019)
Published in Nature (London) (01.01.2019)
Get full text
Journal Article
Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation
Liu, Chao, Karabina, Anastasia, Meller, Artur, Bhattacharjee, Ayan, Agostino, Colby J, Bowman, Greg R, Ruppel, Kathleen M, Spudich, James A, Leinwand, Leslie A
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2024)
Get full text
Journal Article
Dilated cardiomyopathy myosin mutants have reduced force-generating capacity
Ujfalusi, Zoltan, Vera, Carlos D., Mijailovich, Srbolujub M., Svicevic, Marina, Yu, Elizabeth Choe, Kawana, Masataka, Ruppel, Kathleen M., Spudich, James A., Geeves, Michael A., Leinwand, Leslie A.
Published in The Journal of biological chemistry (08.06.2018)
Published in The Journal of biological chemistry (08.06.2018)
Get full text
Journal Article
Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties
Vera, Carlos D., Johnson, Chloe A., Walklate, Jonathan, Adhikari, Arjun, Svicevic, Marina, Mijailovich, Srboljub M., Combs, Ariana C., Langer, Stephen J., Ruppel, Kathleen M., Spudich, James A., Geeves, Michael A., Leinwand, Leslie A.
Published in The Journal of biological chemistry (15.11.2019)
Published in The Journal of biological chemistry (15.11.2019)
Get full text
Journal Article
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration
Lee, Soah, Vander Roest, Alison S, Blair, Cheavar A, Kao, Kerry, Bremner, Samantha B, Childers, Matthew C, Pathak, Divya, Heinrich, Paul, Lee, Daniel, Chirikian, Orlando, Mohran, Saffie E, Roberts, Brock, Smith, Jacqueline E, Jahng, James W, Paik, David T, Wu, Joseph C, Gunawardane, Ruwanthi N, Ruppel, Kathleen M, Mack, David L, Pruitt, Beth L, Regnier, Michael, Wu, Sean M, Spudich, James A, Bernstein, Daniel
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2024)
Get full text
Journal Article
Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin
Pan, Stephen, Sommese, Ruth F, Sallam, Karim I, Nag, Suman, Sutton, Shirley, Miller, Susan M, Spudich, James A, Ruppel, Kathleen M, Ashley, Euan A
Published in BMC medical genetics (26.10.2015)
Published in BMC medical genetics (26.10.2015)
Get full text
Journal Article
Multidimensional structure-function relationships in human [Beta]-cardiac myosin from population-scale genetic variation
Homburger, Julian R, Green, Eric M, Caleshu, Colleen, Sunitha, Margaret S, Taylor, Rebecca E, Ruppel, Kathleen M, Metpally, Raghu Prasad Rao, Colan, Steven D, Michels, Michelle, Day, Sharlene M, Olivotto, Iacopo, Bustamante, Carlos D, Dewey, Frederick E, Ho, Carolyn Y, Spudich, James A, Ashley, Euan A
Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2016)
Get full text
Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2016)
Journal Article
Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
Morck, Makenna, Bhowmik, Debanjan, Dawood, Aminah, Spudich, James, Ruppel, Kathleen M
Published in bioRxiv (12.10.2021)
Published in bioRxiv (12.10.2021)
Get full text
Paper
Controlling load-dependent contractility of the heart at the single molecule level
Liu, Chao, Kawana, Masataka, Song, Dan, Ruppel, Kathleen M, Spudich, James
Published in bioRxiv (05.04.2018)
Published in bioRxiv (05.04.2018)
Get full text
Paper