Shaping proteostasis at the cellular, tissue, and organismal level
Sala, Ambre J, Bott, Laura C, Morimoto, Richard I
Published in The Journal of cell biology (01.05.2017)
Published in The Journal of cell biology (01.05.2017)
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Journal Article
Embryo integrity regulates maternal proteostasis and stress resilience
Sala, Ambre J, Bott, Laura C, Brielmann, Renee M, Morimoto, Richard I
Published in Genes & development (01.05.2020)
Published in Genes & development (01.05.2020)
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Journal Article
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD
Tresse, Emilie, Salomons, Florian A., Vesa, Jouni, Bott, Laura C., Kimonis, Virginia, Yao, Tso-Pang, Dantuma, Nico P., Taylor, J. Paul
Published in Autophagy (16.02.2010)
Published in Autophagy (16.02.2010)
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Journal Article
Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues
Sala, Ambre J, Grant, Rogan A, Imran, Ghania, Morton, Claire, Brielmann, Renee M, Gorgoń, Szymon, Watts, Jennifer, Bott, Laura C, Morimoto, Richard I
Published in Genes & development (25.06.2024)
Published in Genes & development (25.06.2024)
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Journal Article
Muscle Matters in Kennedy’s Disease
Rinaldi, Carlo, Bott, Laura C., Fischbeck, Kenneth H.
Published in Neuron (Cambridge, Mass.) (16.04.2014)
Published in Neuron (Cambridge, Mass.) (16.04.2014)
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Journal Article
A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy
Bott, Laura C, Badders, Nisha M, Chen, Ke-Lian, Harmison, George G, Bautista, Elaine, Shih, Charles C-Y, Katsuno, Masahisa, Sobue, Gen, Taylor, J Paul, Dantuma, Nico P, Fischbeck, Kenneth H, Rinaldi, Carlo
Published in Human molecular genetics (15.05.2016)
Published in Human molecular genetics (15.05.2016)
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Journal Article
MiR-298 Counteracts Mutant Androgen Receptor Toxicity in Spinal and Bulbar Muscular Atrophy
Pourshafie, Naemeh, Lee, Philip R, Chen, Ke-lian, Harmison, George G, Bott, Laura C, Katsuno, Masahisa, Sobue, Gen, Burnett, Barrington G, Fischbeck, Kenneth H, Rinaldi, Carlo
Published in Molecular therapy (01.05.2016)
Published in Molecular therapy (01.05.2016)
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Journal Article
Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity
Kitamura, Akira, Fujimoto, Ai, Kawashima, Rei, Lyu, Yidan, Sasaki, Kotetsu, Hamada, Yuta, Moriya, Kanami, Kurata, Ayumi, Takahashi, Kazuho, Brielmann, Reneé, Bott, Laura C., Morimoto, Richard I., Kinjo, Masataka
Published in Communications biology (20.06.2024)
Published in Communications biology (20.06.2024)
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Journal Article
Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia
Rinaldi, Carlo, Schmidt, Thomas, Situ, Alan J, Johnson, Janel O, Lee, Philip R, Chen, Ke-Lian, Bott, Laura C, Fadó, Rut, Harmison, George H, Parodi, Sara, Grunseich, Christopher, Renvoisé, Benoît, Biesecker, Leslie G, De Michele, Giuseppe, Santorelli, Filippo M, Filla, Alessandro, Stevanin, Giovanni, Dürr, Alexandra, Brice, Alexis, Casals, Núria, Traynor, Bryan J, Blackstone, Craig, Ulmer, Tobias S, Fischbeck, Kenneth H
Published in JAMA neurology (01.05.2015)
Published in JAMA neurology (01.05.2015)
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Journal Article
Insulinlike growth factor (IGF)-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophy
Rinaldi, Carlo, Bott, Laura C, Chen, Ke-lian, Harmison, George G, Katsuno, Masahisa, Sobue, Gen, Pennuto, Maria, Fischbeck, Kenneth H
Published in Molecular medicine (Cambridge, Mass.) (2012)
Published in Molecular medicine (Cambridge, Mass.) (2012)
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Journal Article
The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex
Bott, Laura C, Salomons, Florian A, Maric, Dragan, Liu, Yuhong, Merry, Diane, Fischbeck, Kenneth H, Dantuma, Nico P
Published in Scientific reports (17.06.2016)
Published in Scientific reports (17.06.2016)
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Journal Article
Sexual Reassignment Fails to Prevent Kennedy's Disease
Lanman, Tyler A, Bakar, Dara, Badders, Nisha M, Burke, Ailbhe, Kokkinis, Angela, Shrader, Joseph A, Joe, Galen O, Schindler, Alice B, Bott, Laura C, Harmison, George G, Taylor, J Paul, Fischbeck, Kenneth H, Grunseich, Christopher
Published in Journal of neuromuscular diseases (03.03.2016)
Published in Journal of neuromuscular diseases (03.03.2016)
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