Rofecoxib [Vioxx, MK-0966; 4-(4â²-Methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A Potent and Orally Active Cyclooxygenase-2 Inhibitor. Pharmacological and Biochemical Profiles
Chan, C C, Boyce, S, Brideau, C, Charleson, S, Cromlish, W, Ethier, D, Evans, J, Ford-Hutchinson, A W, Forrest, M J, Gauthier, J Y, Gordon, R, Gresser, M, Guay, J, Kargman, S, Kennedy, B, Leblanc, Y, Leger, S, Mancini, J, O'Neill, G P, Ouellet, M, Patrick, D, Percival, M D, Perrier, H, Prasit, P, Rodger, I
Published in The Journal of pharmacology and experimental therapeutics (01.08.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.08.1999)
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The discovery of rofecoxib, [MK 966, VIOXX ®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5 H)-furanone], an orally active cyclooxygenase-2 inhibitor
Prasit, P, Wang, Z, Brideau, C, Chan, C.-C, Charleson, S, Cromlish, W, Ethier, D, Evans, J.F, Ford-Hutchinson, A.W, Gauthier, J.Y, Gordon, R, Guay, J, Gresser, M, Kargman, S, Kennedy, B, Leblanc, Y, Léger, S, Mancini, J, O'Neill, G.P, Ouellet, M, Percival, M.D, Perrier, H, Riendeau, D, Rodger, I, Tagari, P, Thérien, M, Vickers, P, Wong, E, Xu, L.-J, Young, R.N, Zamboni, R, Boyce, S, Rupniak, N, Forrest, M, Visco, D, Patrick, D
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
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From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors
Black, W.C., Bayly, C., Belley, M., Chan, C.-C., Charleson, S., Denis, D., Gauthier, J.Y., Gordon, R., Guay, D., Kargman, S., Lau, C.K., Leblanc, Y., Mancini, J., Ouellet, M., Percival, D., Roy, P., Skorey, K., Tagari, P., Vickers, P., Wong, E., Xu, L., Prasit, P.
Published in Bioorganic & medicinal chemistry letters (19.03.1996)
Published in Bioorganic & medicinal chemistry letters (19.03.1996)
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Morphological characterization of substance P-like immunoreactive glomeruli in the superficial dorsal horn of the rat spinal cord and trigeminal subnucleus caudalis: a quantitative study
Ribeiro-da-Silva, A, Tagari, P, Cuello, A C
Published in Journal of comparative neurology (1911) (22.03.1989)
Published in Journal of comparative neurology (1911) (22.03.1989)
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Synthesis and biological evaluation of both enantiomers of L-761,000 as inhibitors of cyclooxygenase 1 and 2
Leblanc, Y., Black, W.C., Chan, C.C., Charleson, S., Delorme, D., Denis, D., Gauthier, J.Y., Grimm, E.L., Gordon, R., Guay, D., Hamel, P., Kargman, S., Lau, C.K., Mancini, J., Ouellet, M., Percival, D., Roy, P., Skorey, K., Tagari, P., Vickers, P., Wong, E., Xu, L., Prasit, P.
Published in Bioorganic & medicinal chemistry letters (19.03.1996)
Published in Bioorganic & medicinal chemistry letters (19.03.1996)
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Journal Article
Increased urinary LTE4 excretion following inhalation of LTC4 and LTE4 in asthmatic subjects
Christie, PE, Tagari, P, Ford-Hutchinson, AW, Black, C, Markendorf, A, Schmitz-Schumann, M, Lee, TH
Published in The European respiratory journal (01.05.1994)
Published in The European respiratory journal (01.05.1994)
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Measurement of urinary leukotrienes by reversed-phase liquid chromatography and radioimmunoassay
Tagari, P, Ethier, D, Carry, M, Korley, V, Charleson, S, Girard, Y, Zamboni, R
Published in Clinical chemistry (Baltimore, Md.) (01.03.1989)
Published in Clinical chemistry (Baltimore, Md.) (01.03.1989)
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Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor
Brideau, C, Chan, C, Charleson, S, Denis, D, Evans, J F, Ford-Hutchinson, A W, Fortin, R, Gillard, J W, Guay, J, Guévremont, D
Published in Canadian journal of physiology and pharmacology (01.06.1992)
Published in Canadian journal of physiology and pharmacology (01.06.1992)
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Effect of FLAP antagonist MK-0591 on leukotriene production and ozone-induced airway responses in dogs
Stevens, W H, Lane, C G, Woolley, M J, Ellis, R, Tagari, P, Black, C, Ford-Hutchinson, A, O'Byrne, P M
Published in Journal of applied physiology (1985) (01.04.1994)
Published in Journal of applied physiology (1985) (01.04.1994)
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Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816
Hutchinson, J. H, Riendeau, D, Brideau, C, Chan, C, Delorme, D, Denis, D, Falgueyret, J. P, Fortin, R, Guay, J
Published in Journal of medicinal chemistry (01.09.1993)
Published in Journal of medicinal chemistry (01.09.1993)
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Neural plasticity of basal forebrain cholinergic neurons: effects of gangliosides
Stephens, P H, Tagari, P C, Garofalo, L, Maysinger, D, Piotte, M, Cuello, A C
Published in Neuroscience letters (11.09.1987)
Published in Neuroscience letters (11.09.1987)
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Thiopyrano[2,3,4-cd]indoles as 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Resolution of 2-[2-[1-(4-Chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic Acid
Hutchinson, J. H, Riendeau, D, Brideau, C, Chan, C, Falgueyret, J.-P, Guay, J, Jones, T. R, Lepine, C, Macdonald, D
Published in Journal of medicinal chemistry (01.04.1994)
Published in Journal of medicinal chemistry (01.04.1994)
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Journal Article
Antiasthmatic effects of a leukotriene biosynthesis inhibitor (MK-0591) in allergic dogs
Becker, A B, Black, C, Lilley, M K, Bajwa, K, Ford-Hutchinson, A W, Simons, F E, Tagari, P
Published in Journal of applied physiology (1985) (01.02.1995)
Published in Journal of applied physiology (1985) (01.02.1995)
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