The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions
Abdulrahman, Basant A., Abdelaziz, Dalia, Thapa, Simrika, Lu, Li, Jain, Shubha, Gilch, Sabine, Proniuk, Stefan, Zukiwski, Alexander, Schatzl, Hermann M.
Published in Scientific reports (14.12.2017)
Published in Scientific reports (14.12.2017)
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Phase I study of onapristone, a type I antiprogestin, in female patients with previously treated recurrent or metastatic progesterone receptor-expressing cancers
Cottu, Paul H, Bonneterre, Jacques, Varga, Andrea, Campone, Mario, Leary, Alexandra, Floquet, Anne, Berton-Rigaud, Dominique, Sablin, Marie-Paule, Lesoin, Anne, Rezai, Keyvan, Lokiec, François M, Lhomme, Catherine, Bosq, Jacques, Bexon, Alice S, Gilles, Erard M, Proniuk, Stefan, Dieras, Veronique, Jackson, David M, Zukiwski, Alexander, Italiano, Antoine
Published in PloS one (10.10.2018)
Published in PloS one (10.10.2018)
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651 A phase 1, multicenter, open-label, dose-escalation, safety, pharmacodynamic, pharmacokinetic study of Q702 with a cohort expansion at the RP2D in patients with advanced solid tumors
Mahalingam, Devalingam, Alistar, Angela, Mita, Alain, Kim, Jeongjun, Ahn, Hyunji, Choi, Jinho, Ryu, Seung-Hee, Ahn, Jiye, Choi, Bae Jung, Kang, Hwankyu, Yang, Yeong-In, Lee, Seung-Joo, Jeon, Borami, Proniuk, Stefan, Nam, Kiyean, El-Khoueiry, Anthony
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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645 A phase 1B/2, open-label study of Q702 in combination with intravenous pembrolizumab in patients with selected advanced solid tumors
Kim, Seung-Tae, Chon, Hong Jae, Oh, Do-Youn, Grewal, Jaspreet, Rha, Sun Young, El-Khoueiry, Anthony, Ryoo, Baek-Yeol, Kim, Jeongjun, Ahn, Hyunji, Ryu, Seung-Hee, Choi, Jinho, Choi, Bae Jung, Ahn, Jiye, Kang, Hwankyu, Yang, Yeong-In, Lee, Seung-Joo, Jeon, Borami, Proniuk, Stefan, Nam, Kiyean
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Exploring the in vitro potential of celecoxib derivative AR-12 as an effective antiviral compound against four dengue virus serotypes
Hassandarvish, Pouya, Oo, Adrian, Jokar, Amin, Zukiwski, Alexander, Proniuk, Stefan, Abu Bakar, Sazaly, Zandi, Keivan
Published in Journal of antimicrobial chemotherapy (01.09.2017)
Published in Journal of antimicrobial chemotherapy (01.09.2017)
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Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function
Booth, Laurence, Shuch, Brian, Albers, Thomas, Roberts, Jane L, Tavallai, Mehrad, Proniuk, Stefan, Zukiwski, Alexander, Wang, Dasheng, Chen, Ching-Shih, Bottaro, Don, Ecroyd, Heath, Lebedyeva, Iryna O, Dent, Paul
Published in Oncotarget (15.03.2016)
Published in Oncotarget (15.03.2016)
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ACTR-40. PHASE 2 SAFETY AND EFFICACY OF AR-67 (7-T-BUTYLDIMETHYLSILTYL-10-HYDROXYCAMPTOTHECIN) IN PATIENTS WITH RECURRENT GLIOBLASTOMA MULTIFORME (GBM) OR GLIOSARCOMA
Kumthekar, Priya, Raizer, Jeffrey, Cavaliere, Robert, Devoe, Craig, Jensen, Randy, Stieber, Volker, Runk, Tina, Grewal, Jai, Brownell, Elise, Zukiwski, Alex, Proniuk, Stefan, Arnold, Susanne, Vredenburgh, James
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2019)
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2019)
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AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication
Booth, Laurence, Roberts, Jane L., Ecroyd, Heath, Tritsch, Sarah R., Bavari, Sina, Reid, St. Patrick, Proniuk, Stefan, Zukiwski, Alexander, Jacob, Abraham, Sepúlveda, Claudia S., Giovannoni, Federico, García, Cybele C., Damonte, Elsa, González-Gallego, Javier, Tuñón, María J., Dent, Paul
Published in Journal of cellular physiology (01.10.2016)
Published in Journal of cellular physiology (01.10.2016)
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Abstract 4636: Pharmacokinetic (PK) food effect study of immediate-release onapristone and its primary metabolite (M1) in healthy female subjects: implications for design of a new formulation
Rezai, Keyvan, Proniuk, Stefan, Zukiwski, Alex, Gilles, Erard, Chassard, Didier, Denot, Caroline, Ramos, Haydee L., Bexon, Alice S., Lokiec, François
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Abstract 1646: Synthesis of [11C]onapristone for clinical investigation
Madar, Olivier, Fouque, Julien, Proniuk, Stefan, Rezai, Keyvan, Huguet, Samuel, Zukiwski, Alexander, Gilles, Erard M., Bexon, Alice S., Lokiec, François
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Validation of a population pharmacokinetic (PPK) model for onapristone (ONA) in patients (pts) with cancer: Analysis of 2 clinical trials
Rezai, Keyvan, Huguet, Samuel, Bret, Fanny, Cottu, Paul H., Attard, Gerhardt, Italiano, Antoine, Varga, Andrea, Bonneterre, Jacques, Campone, Mario, Jayaram, Anuradha, Bexon, Alice Susannah, Gilles, Erard M., Proniuk, Stefan, Barranco, Charles, Zukiwski, Alexander, Lokiec, Francois Marc
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Phase 1-2 study of progesterone receptor (PR) inhibition with extended-release (ER) onapristone (ONA) alone or in combination with abiraterone (AA) in patients (pts) with castration-resistant prostate cancer (CRPC) incorporating plasma DNA analysis to define androgen receptor (AR) status
Jayaram, Anuradha, Nowakowska, Karolina, Mateo, Joaquin, Kumar, Sanjeev, Hernandez, Tatiana, Fulton, Ben, Nava Rodrigues, Daniel, Riisnaes, Ruth, Zukiwski, Alexander, Bexon, Alice Susannah, Proniuk, Stefan, Barranco, Charles, Bianchini, Diletta, Zafeirou, Zafeiris, Perez Lopez, Raquel, Tunariu, Nina, Pacey, Simon, Jones, Robert J., De Bono, Johann S., Attard, Gerhardt
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
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Abstract 4523: Population pharmacokinetic (PPK) modeling of onapristone in patients (pts) with progesterone receptor (PR)-expressing cancers
Rezai, Keyvan, Cottu, Paul, Huguet, Samuel, Campone, Mario, Italiano, Antoine, Varga, Andrea, Bonneterre, Jacques, Leary, Alexandra, Sablin, Marie-Paule, Proniuk, Stefan, Bexon, Alice, Gilles, Erard, Bisaha, Joseph, Zukiwski, Alexander, Lokiec, Francois
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract 4512: Onapristone in patients (pts) with progesterone receptor (PR)-expressing cancers: PK results from part 1 of a randomized, parallel-dose phase 1 study
Lokiec, Francois, Italiano, Antoine, Varga, Andrea, Bonneterre, Jacques, Campone, Mario, Leary, Alexandra, Rezai, Keyvan, Sablin, Marie-Paule, Bexon, Alice, Proniuk, Stefan, Gilles, Erard, Bisaha, Joseph, Zukiwski, Alexander, Cottu, Paul
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Phase 1-2 study of progesterone receptor (PR) inhibition with extended-release (ER) onapristone (ONA) in patients (pts) with castration-resistant prostate cancer (CRPC): PK, safety and PR testing results from the dose escalation cohort
Jayaram, Anuradha, Nowakowska, Karolina, Mateo, Joaquin, Nava Rodrigues, Daniel, Riisnaes, Ruth, Zukiwski, Alexander, Proniuk, Stefan, Bexon, Alice Susannah, Bisaha, Joseph, Bianchini, Diletta, Zafeiriou, Zafeiris, Perez Lopez, Raquel, Tunariu, Nina, De Bono, Johann Sebastian, Attard, Gerhardt
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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A phase 1-2 study of the type I progesterone receptor (PR) antagonist onapristone (ONA) in patients (pts) with advanced castration-resistant prostate cancer (CRPC)
Mateo, Joaquin, Nava Rodrigues, Daniel, Perez Lopez, Raquel, Flohr, Penelope, Riisnaes, Ruth, Lokiec, Francois Marc, Zukiwski, Alexander, Proniuk, Stefan, Bexon, Alice Susannah, Paquin, Andre, Bisaha, Joseph, Tunariu, Nina, De Bono, Johann Sebastian, Attard, Gerhardt
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
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