First-in-human phase 1 study of margetuximab (MGAH22), an Fc-modified chimeric monoclonal antibody, in patients with HER2-positive advanced solid tumors
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SH2 domains recognize specific phosphopeptide sequences
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Smad proteins regulate transcriptional induction of the SM22α gene by TGF‐β
Chen, Shiyou, Kulik, Magdalena, Lechleider, Robert J.
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Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2
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Published in The Journal of biological chemistry (25.06.1993)
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A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif
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SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides
CASE, R D, PICCIONE, E, WOLF, G, BENETT, A. M, LECHLEIDER, R. J, NEEL, B. J, SHOELSON, S. E
Published in The Journal of biological chemistry (08.04.1994)
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Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases
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Published in Genes & development (01.06.1998)
Published in Genes & development (01.06.1998)
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The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors
Wang, Tongwen, Li, Bi-Yu, Danielson, Paul D, Shah, Paresh C, Rockwell, Sybil, Lechleider, Robert J, Martin, Jennifer, Manganaro, Thomas, Donahoe, Patricia K
Published in Cell (09.08.1996)
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Sorting Nexin 6, a Novel SNX, Interacts with the Transforming Growth Factor-β Family of Receptor Serine-Threonine Kinases
Parks, W. Tony, Frank, David B., Huff, Carla, Renfrew Haft, Carol, Martin, Jennifer, Meng, Xianwang, de Caestecker, Mark P., McNally, James G., Reddi, Amit, Taylor, Simeon I., Roberts, Anita B., Wang, Tongwen, Lechleider, Robert J.
Published in The Journal of biological chemistry (01.06.2001)
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SMAD3/4-Dependent Transcriptional Activation of the Human Type VII Collagen Gene (COL7A1) Promoter by Transforming Growth Factor β
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Published in Proceedings of the National Academy of Sciences - PNAS (08.12.1998)
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The Smad4 Activation Domain (SAD) Is a Proline-rich, p300-dependent Transcriptional Activation Domain
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Published in The Journal of biological chemistry (21.01.2000)
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A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction
Kim, R H, Wang, D, Tsang, M, Martin, J, Huff, C, de Caestecker, M P, Parks, W T, Meng, X, Lechleider, R J, Wang, T, Roberts, A B
Published in Genes & development (01.07.2000)
Published in Genes & development (01.07.2000)
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The MSG1 Non-DNA-binding Transactivator Binds to the p300/CBP Coactivators, Enhancing Their Functional Link to the Smad Transcription Factors
Yahata, Tetsuro, de Caestecker, Mark P., Lechleider, Robert J., Andriole, Stephanie, Roberts, Anita B., Isselbacher, Kurt J., Shioda, Toshi
Published in The Journal of biological chemistry (24.03.2000)
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404 Phase I study of MEDI-575, a fully human monoclonal antibody targeting PDGFR-alpha in subjects with advanced solid tumors
Lechleider, R, Becerra, C, Liang, M, Narwal, R, Shi, L, Conkling, P, Galsky, M, Jotte, R, Wu, H, Vogelzang, N.J
Published in European journal of cancer supplements (2010)
Published in European journal of cancer supplements (2010)
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Smad-dependent Transcriptional Activation of Human Type VII Collagen Gene (COL7A1) Promoter by Transforming Growth Factor-β
Vindevoghel, Laurence, Kon, Atsushi, Lechleider, Robert J., Uitto, Jouni, Roberts, Anita B., Mauviel, Alain
Published in The Journal of biological chemistry (22.05.1998)
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Transforming Growth Factor-β Receptor-associated Protein 1 Is a Smad4 Chaperone
Wurthner, Jens U., Frank, David B., Felici, Angelina, Green, Harry M., Cao, Zhouhong, Schneider, Michael D., McNally, James G., Lechleider, Robert J., Roberts, Anita B.
Published in The Journal of biological chemistry (01.06.2001)
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