Direct detection of early-stage cancers using circulating tumor DNA
Phallen, Jillian, Sausen, Mark, Adleff, Vilmos, Leal, Alessandro, Hruban, Carolyn, White, James, Anagnostou, Valsamo, Fiksel, Jacob, Cristiano, Stephen, Papp, Eniko, Speir, Savannah, Reinert, Thomas, Orntoft, Mai-Britt Worm, Woodward, Brian D, Murphy, Derek, Parpart-Li, Sonya, Riley, David, Nesselbush, Monica, Sengamalay, Naomi, Georgiadis, Andrew, Li, Qing Kay, Madsen, Mogens Rørbæk, Mortensen, Frank Viborg, Huiskens, Joost, Punt, Cornelis, van Grieken, Nicole, Fijneman, Remond, Meijer, Gerrit, Husain, Hatim, Scharpf, Robert B, Diaz, Jr, Luis A, Jones, Siân, Angiuoli, Sam, Ørntoft, Torben, Nielsen, Hans Jørgen, Andersen, Claus Lindbjerg, Velculescu, Victor E
Published in Science translational medicine (16.08.2017)
Published in Science translational medicine (16.08.2017)
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Early Noninvasive Detection of Response to Targeted Therapy in Non-Small Cell Lung Cancer
Phallen, Jillian, Leal, Alessandro, Woodward, Brian D, Forde, Patrick M, Naidoo, Jarushka, Marrone, Kristen A, Brahmer, Julie R, Fiksel, Jacob, Medina, Jamie E, Cristiano, Stephen, Palsgrove, Doreen N, Gocke, Christopher D, Bruhm, Daniel C, Keshavarzian, Parissa, Adleff, Vilmos, Weihe, Elizabeth, Anagnostou, Valsamo, Scharpf, Robert B, Velculescu, Victor E, Husain, Hatim
Published in Cancer research (Chicago, Ill.) (15.03.2019)
Published in Cancer research (Chicago, Ill.) (15.03.2019)
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Journal Article
DNA methylation and gene expression as determinants of genome-wide cell-free DNA fragmentation
Noë, Michaël, Mathios, Dimitrios, Annapragada, Akshaya V., Koul, Shashikant, Foda, Zacharia H., Medina, Jamie E., Cristiano, Stephen, Cherry, Christopher, Bruhm, Daniel C., Niknafs, Noushin, Adleff, Vilmos, Ferreira, Leonardo, Easwaran, Hari, Baylin, Stephen, Phallen, Jillian, Scharpf, Robert B., Velculescu, Victor E.
Published in Nature communications (06.08.2024)
Published in Nature communications (06.08.2024)
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Journal Article
Bayesian copy number detection and association in large-scale studies
Cristiano, Stephen, McKean, David, Carey, Jacob, Bracci, Paige, Brennan, Paul, Chou, Michael, Du, Mengmeng, Gallinger, Steven, Goggins, Michael G, Hassan, Manal M, Hung, Rayjean J, Kurtz, Robert C, Li, Donghui, Lu, Lingeng, Neale, Rachel, Olson, Sara, Petersen, Gloria, Rabe, Kari G, Fu, Jack, Risch, Harvey, Rosner, Gary L, Ruczinski, Ingo, Klein, Alison P, Scharpf, Robert B
Published in BMC cancer (07.09.2020)
Published in BMC cancer (07.09.2020)
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Genome-Wide Association of Copy Number Polymorphisms and Kidney Function
Li, Man, Carey, Jacob, Cristiano, Stephen, Susztak, Katalin, Coresh, Josef, Boerwinkle, Eric, Kao, Wen Hong L, Beaty, Terri H, Köttgen, Anna, Scharpf, Robert B
Published in PloS one (30.01.2017)
Published in PloS one (30.01.2017)
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Whole exome association of rare deletions in multiplex oral cleft families
Fu, Jack, Beaty, Terri H., Scott, Alan F., Hetmanski, Jacqueline, Parker, Margaret M., Wilson, Joan E. Bailey, Marazita, Mary L., Mangold, Elisabeth, Albacha‐Hejazi, Hasan, Murray, Jeffrey C., Bureau, Alexandre, Carey, Jacob, Cristiano, Stephen, Ruczinski, Ingo, Scharpf, Robert B.
Published in Genetic epidemiology (01.01.2017)
Published in Genetic epidemiology (01.01.2017)
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Journal Article
Genome-wide cell-free DNA fragmentation in patients with cancer
Cristiano, Stephen, Leal, Alessandro, Phallen, Jillian, Fiksel, Jacob, Adleff, Vilmos, Bruhm, Daniel C., Jensen, Sarah Østrup, Medina, Jamie E., Hruban, Carolyn, White, James R., Palsgrove, Doreen N., Niknafs, Noushin, Anagnostou, Valsamo, Forde, Patrick, Naidoo, Jarushka, Marrone, Kristen, Brahmer, Julie, Woodward, Brian D., Husain, Hatim, van Rooijen, Karlijn L., Ørntoft, Mai-Britt Worm, Madsen, Anders Husted, van de Velde, Cornelis J. H., Verheij, Marcel, Cats, Annemieke, Punt, Cornelis J. A., Vink, Geraldine R., van Grieken, Nicole C. T., Koopman, Miriam, Fijneman, Remond J. A., Johansen, Julia S., Nielsen, Hans Jørgen, Meijer, Gerrit A., Andersen, Claus Lindbjerg, Scharpf, Robert B., Velculescu, Victor E.
Published in Nature (London) (01.06.2019)
Published in Nature (London) (01.06.2019)
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Journal Article
Detection and characterization of lung cancer using cell-free DNA fragmentomes
Mathios, Dimitrios, Johansen, Jakob Sidenius, Cristiano, Stephen, Medina, Jamie E., Phallen, Jillian, Larsen, Klaus R., Bruhm, Daniel C., Niknafs, Noushin, Ferreira, Leonardo, Adleff, Vilmos, Chiao, Jia Yuee, Leal, Alessandro, Noe, Michael, White, James R., Arun, Adith S., Hruban, Carolyn, Annapragada, Akshaya V., Jensen, Sarah Østrup, Ørntoft, Mai-Britt Worm, Madsen, Anders Husted, Carvalho, Beatriz, de Wit, Meike, Carey, Jacob, Dracopoli, Nicholas C., Maddala, Tara, Fang, Kenneth C., Hartman, Anne-Renee, Forde, Patrick M., Anagnostou, Valsamo, Brahmer, Julie R., Fijneman, Remond J. A., Nielsen, Hans Jørgen, Meijer, Gerrit A., Andersen, Claus Lindbjerg, Mellemgaard, Anders, Bojesen, Stig E., Scharpf, Robert B., Velculescu, Victor E.
Published in Nature communications (20.08.2021)
Published in Nature communications (20.08.2021)
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Journal Article
Detecting Liver Cancer Using Cell-Free DNA Fragmentomes
Foda, Zachariah H, Annapragada, Akshaya V, Boyapati, Kavya, Bruhm, Daniel C, Vulpescu, Nicholas A, Medina, Jamie E, Mathios, Dimitrios, Cristiano, Stephen, Niknafs, Noushin, Luu, Harry T, Goggins, Michael G, Anders, Robert A, Sun, Jing, Meta, Shruti H, Thomas, David L, Kirk, Gregory D, Adleff, Vilmos, Phallen, Jillian, Scharpf, Robert B, Kim, Amy K, Velculescu, Victor E
Published in Cancer discovery (01.03.2023)
Published in Cancer discovery (01.03.2023)
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Cell-Free DNA Fragmentomes in the Diagnostic Evaluation of Patients With Symptoms Suggestive of Lung Cancer
Leal, Alessandro I.C., Mathios, Dimitrios, Jakubowski, Debbie, Johansen, Jakob S., Lau, Anna, Wu, Tony, Cristiano, Stephen, Medina, Jamie E., Phallen, Jillian, Bruhm, Daniel C., Carey, Jacob, Dracopoli, Nicholas C., Bojesen, Stig E., Scharpf, Robert B., Velculescu, Victor E., Vachani, Anil, Bach, Peter B.
Published in Chest (01.10.2023)
Published in Chest (01.10.2023)
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Single-molecule genome-wide mutation profiles of cell-free DNA for non-invasive detection of cancer
Bruhm, Daniel C., Mathios, Dimitrios, Foda, Zachariah H., Annapragada, Akshaya V., Medina, Jamie E., Adleff, Vilmos, Chiao, Elaine Jiayuee, Ferreira, Leonardo, Cristiano, Stephen, White, James R., Mazzilli, Sarah A., Billatos, Ehab, Spira, Avrum, Zaidi, Ali H., Mueller, Jeffrey, Kim, Amy K., Anagnostou, Valsamo, Phallen, Jillian, Scharpf, Robert B., Velculescu, Victor E.
Published in Nature genetics (01.08.2023)
Published in Nature genetics (01.08.2023)
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Journal Article
Early detection of lung cancer using cfDNA fragmentation
Mathios, Dimitrios, Johansen, Jakob Sidenius, Cristiano, Stephen, Medina, Jamie, Phallen, Jillian, Richter Larsen, Klaus, Bruhm, Daniel, Niknafs, Noushin, Nielsen, Hans J., Meijer, Gerrit A., Andersen, Claus Lindbjerg, Bojesen, Stig Egil, Scharpf, Robert, Velculescu, Victor E.
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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Abstract 981: Robustness of fragmentation-based cell-free DNA approaches to clonal hematopoiesis
Cristiano, Stephen, Alipanahi, Bahar, Medina, Jamie E., Rinaldi, Lorenzo, Dracopoli, Nicholas, Scharpf, Robert B., Leal, Alessandro, Velculescu, Victor E., Tom, Jennifer
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 6101: PLASMUT: An R Package for estimating the probability of tumor-specific mutations in cell-free DNA
Arun, Adith S., Medina, Jamie E., Cristiano, Stephen, Bruhm, Daniel C., Fijneman, Remond J., Meijer, Gerrit A., Leal, Alessandro, Velculescu, Victor E., Scharpf, Robert B.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Early detection of ovarian cancer using cell-free DNA fragmentomes and protein biomarkers
Medina, Jamie E, Annapragada, Akshaya V, Lof, Pien, Short, Sarah, Bartolomucci, Adrianna L, Mathios, Dimitrios, Koul, Shashikant, Niknafs, Noushin, Noe, Michael, Foda, Zachariah H, Bruhm, Daniel C, Hruban, Carolyn, Vulpescu, Nicholas A, Jung, Euihye, Dua, Renu, Canzoniero, Jenna V, Cristiano, Stephen, Adleff, Vilmos, Symecko, Heather, van den Broek, Daan, Sokoll, Lori J, Baylin, Stephen B, Press, Michael F, Slamon, Dennis J, Konecny, Gottfried E, Therkildsen, Christina, Carvalho, Beatriz, Meijer, Gerrit A, Andersen, Claus Lindbjerg, Domchek, Susan M, Drapkin, Ronny, Scharpf, Robert B, Phallen, Jillian, Lok, Christine A R, Velculescu, Victor E
Published in Cancer discovery (30.09.2024)
Published in Cancer discovery (30.09.2024)
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Abstract 2422: Liquid biopsy approaches for monitoring metastatic pancreatic cancer in immunotherapy treated patients
Hruban, Carolyn Anna, Chen, Inna, Bruhm, Daniel C., Koul, Shashikant, Yao, Jennie, Theile, Susann, Boyapati, Kavya, Vulpescu, Nicholas A., Annapragada, Akshaya, Ferreira, Leonardo, Cristiano, Stephen, Foda, Zachariah H., Adleff, Vilmos, Johansen, Julia, Phallen, Jillian, Scharpf, Robert B., Velculescu, Victor E.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 974: DNA methylation and gene expression as determinants of genome-wide cell-free DNA fragmentation
Noë, Michaël, Annapragada, Akshaya V., Foda, Zachariah H., Medina, Jamie E., Mathios, Dimitrios, Cristiano, Stephen, Cherry, Christopher, Bruhm, Daniel C., Niknafs, Noushin, Adleff, Vilmos, Ferreira, Leonardo, Easwaran, Hari, Baylin, Stephen, Phallen, Jillian, Scharpf, Robert B., Velculescu, Victor E.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Genome-wide cell-free DNA fragmentation profiling for early cancer detection
Leal, Alessandro, Cristiano, Stephen, Phallen, Jillian, Fiksel, Jacob, Adleff, Vilmos, Bruhm, Daniel C., Jensen, Sarah Østrup, Medina, Jamie E., Palsgrove, Doreen N., Niknafs, Noushin, Anagnostou, Valsamo, Forde, Patrick M., Brahmer, Julie R., Fijneman, Remond, Johansen, Julia S., Nielsen, Hans J., Meijer, Gerrit A., Andersen, Claus Lindbjerg, Scharpf, Robert B., Velculescu, Victor E.
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Abstract 5159: Towards population-scale screening of human cancer using genome-wide fragmentation profiles of cell-free DNA
Annapragada, Akshaya V., Mathios, Dimitrios, Cristiano, Stephen, Medina, Jamie E., Adleff, Vilmos, Niknafs, Noushin, Carey, Jacob, Dracopoli, Nic, Bach, Peter, Phallen, Jillian, Velculescu, Victor E., Scharpf, Robert B.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract 4596: Early noninvasive prediction of response to targeted therapy in non-small cell lung cancer
Phallen, Jillian A., Leal, Alessandro, Woodward, Brian D., Forde, Patrick M., Naidoo, Jarushka, Marrone, Kristen, Brahmer, Julie, Fiksel, Jacob, Palsgrove, Doreen N., Cristiano, Stephen, Bruhm, Daniel, Weihe, Elizabeth, Adleff, Vilmos, Keshavarzian, Parissa, Anagnostou, Valsamo, Scharpf, Robert B., Velculescu, Victor E., Husain, Hatim
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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