Development of ADS051, an oral, gut‐restricted, small molecule neutrophil modulator for the treatment of neutrophil‐mediated inflammatory diseases
Murphy, Christopher K., Dixit, Bharat, Oleson, Frederick B., Dolle, Roland E., Farquhar, Ronald, McCormick, Beth A.
Published in FEBS open bio (01.08.2023)
Published in FEBS open bio (01.08.2023)
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A novel dual NLRP1 and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases
Docherty, Callum Ah, Fernando, Anuruddika J, Rosli, Sarah, Lam, Maggie, Dolle, Roland E, Navia, Manuel A, Farquhar, Ronald, La France, Danny, Tate, Michelle D, Murphy, Christopher K, Rossi, Adriano G, Mansell, Ashley
Published in Clinical & translational immunology (01.01.2023)
Published in Clinical & translational immunology (01.01.2023)
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The selective mu-opioid receptor antagonist adl5510 reduces levodopa-induced dyskinesia without affecting antiparkinsonian action in mptp-lesioned macaque model of Parkinson's disease
Koprich, James B., Fox, Susan H., Johnston, Tom H., Goodman, Allan, Le Bourdonnec, Bertrand, Dolle, Roland E., DeHaven, Robert N., DeHaven-Hudkins, Diane L., Little, Patrick J., Brotchie, Jonathan M.
Published in Movement disorders (01.06.2011)
Published in Movement disorders (01.06.2011)
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Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain
LaBuda, Christopher J, Koblish, Michael, Tuthill, Paul, Dolle, Roland E, Little, Patrick J
Published in European journal of pain (01.08.2006)
Published in European journal of pain (01.08.2006)
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Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy
Oh, Young Mi, Lee, Seong Won, Kim, Woo Kyung, Chen, Shawei, Church, Victoria A., Cates, Kitra, Li, Tiandao, Zhang, Bo, Dolle, Roland E., Dahiya, Sonika, Pak, Stephen C., Silverman, Gary A., Perlmutter, David H., Yoo, Andrew S.
Published in Nature neuroscience (01.11.2022)
Published in Nature neuroscience (01.11.2022)
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Discovery of 6‑Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases
Dang, Xiawei, Zhang, Lihong, Franco, Antonietta, Li, Jiajia, Rocha, Agostinho G, Devanathan, Sriram, Dolle, Roland E, Bernstein, Peter R, Dorn, Gerald W
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization
Nozaki, Chihiro, Le Bourdonnec, Bertrand, Reiss, David, Windh, Rolf T, Little, Patrick J, Dolle, Roland E, Kieffer, Brigitte L, Gavériaux-Ruff, Claire
Published in The Journal of pharmacology and experimental therapeutics (01.09.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2012)
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Correction to “Discovery of 6‑Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases”
Dang, Xiawei, Zhang, Lihong, Franco, Antonietta, Li, Jiajia, Rocha, Agostinho G, Devanathan, Sriram, Dolle, Roland E, Bernstein, Peter R, Dorn, Gerald W
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints
Chu, Guo-Hua, Gu, Minghua, Cassel, Joel A., Belanger, Serge, Graczyk, Thomas M., DeHaven, Robert N., Conway-James, Nathalie, Koblish, Mike, Little, Patrick J., DeHaven-Hudkins, Diane L., Dolle, Roland E.
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
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Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1-TFEB pathway to Huntington's disease neurodegeneration
Lee, Seong Won, Oh, Young Mi, Victor, Matheus B, Yang, Yan, Chen, Shawei, Strunilin, Ilya, Dahiya, Sonika, Dolle, Roland E, Pak, Stephen C, Silverman, Gary A, Perlmutter, David H, Yoo, Andrew S
Published in Nature aging (01.01.2024)
Published in Nature aging (01.01.2024)
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Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors
Zhang, Jing, Yang, Qingyi, Cross, Jason B, Romero, Jan Antoinette C, Poutsiaka, Katherine M, Epie, Felix, Bevan, Douglas, Wang, Bin, Zhang, Yanzhi, Chavan, Ajit, Zhang, Xin, Moy, Terence, Daniel, Anu, Nguyen, Kien, Chamberlain, Brian, Carter, Nicole, Shotwell, Joseph, Silverman, Jared, Metcalf, Chester A, Ryan, Dominic, Lippa, Blaise, Dolle, Roland E
Published in Journal of medicinal chemistry (12.11.2015)
Published in Journal of medicinal chemistry (12.11.2015)
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Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design
Cross, Jason B, Zhang, Jing, Yang, Qingyi, Mesleh, Michael F, Romero, Jan Antoinette C, Wang, Bin, Bevan, Doug, Poutsiaka, Katherine M, Epie, Felix, Moy, Terence, Daniel, Anu, Shotwell, Joseph, Chamberlain, Brian, Carter, Nicole, Andersen, Ole, Barker, John, Ryan, M. Dominic, Metcalf, Chester A, Silverman, Jared, Nguyen, Kien, Lippa, Blaise, Dolle, Roland E
Published in ACS medicinal chemistry letters (14.04.2016)
Published in ACS medicinal chemistry letters (14.04.2016)
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Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)
Le Bourdonnec, Bertrand, Windh, Rolf T., Leister, Lara K., Zhou, Q. Jean, Ajello, Christopher W., Gu, Minghua, Chu, Guo-Hua, Tuthill, Paul A., Barker, William M., Koblish, Michael, Wiant, Daniel D., Graczyk, Thomas M., Belanger, Serge, Cassel, Joel A., Feschenko, Marina S., Brogdon, Bernice L., Smith, Steven A., Derelanko, Michael J., Kutz, Steve, Little, Patrick J., DeHaven, Robert N., DeHaven-Hudkins, Diane L., Dolle, Roland E.
Published in Journal of medicinal chemistry (24.09.2009)
Published in Journal of medicinal chemistry (24.09.2009)
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Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors
Zhang, Jing, Yang, Qingyi, Romero, Jan Antoinette C, Cross, Jason, Wang, Bin, Poutsiaka, Katherine M, Epie, Felix, Bevan, Douglas, Wu, Yuchuan, Moy, Terence, Daniel, Anu, Chamberlain, Brian, Carter, Nicole, Shotwell, Joseph, Arya, Anu, Kumar, Vipul, Silverman, Jared, Nguyen, Kien, Metcalf, Chester A, Ryan, Dominic, Lippa, Blaise, Dolle, Roland E
Published in ACS medicinal chemistry letters (08.10.2015)
Published in ACS medicinal chemistry letters (08.10.2015)
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