The Solubility–Permeability Interplay: Mechanistic Modeling and Predictive Application of the Impact of Micellar Solubilization on Intestinal Permeation
Miller, Jonathan M, Beig, Avital, Krieg, Brian J, Carr, Robert A, Borchardt, Thomas B, Amidon, Gregory E, Amidon, Gordon L, Dahan, Arik
Published in Molecular pharmaceutics (03.10.2011)
Published in Molecular pharmaceutics (03.10.2011)
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Direct Visualization of Drug–Polymer Phase Separation in Ritonavir–Copovidone Amorphous Solid Dispersions Using in situ Synchrotron X‑ray Fluorescence Imaging of Thin Films
Shi, Chenyang, Li, Luxi, Zhang, Geoff G. Z, Borchardt, Thomas B
Published in Molecular pharmaceutics (04.11.2019)
Published in Molecular pharmaceutics (04.11.2019)
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Journal Article
Efficient Co-crystal Screening Using Solution-Mediated Phase Transformation
Zhang, Geoff G.Z., Henry, Rodger F., Borchardt, Thomas B., Lou, Xiaochun
Published in Journal of pharmaceutical sciences (01.05.2007)
Published in Journal of pharmaceutical sciences (01.05.2007)
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Journal Article
Co-Crystals of Caffeine and Hydroxy-2-naphthoic Acids: Unusual Formation of the Carboxylic Acid Dimer in the Presence of a Heterosynthon
Bučar, Dejan-Krešimir, Henry, Rodger F., Lou, Xiaochun, Duerst, Richard W., Borchardt, Thomas B., MacGillivray, Leonard R., Zhang, Geoff G. Z.
Published in Molecular pharmaceutics (01.05.2007)
Published in Molecular pharmaceutics (01.05.2007)
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Journal Article
Thermochemistry and Conformational Polymorphism of a Hexamorphic Crystal System
Yu, Lian, Stephenson, Gregory A, Mitchell, Christine A, Bunnell, Charles A, Snorek, Sharon V, Bowyer, J. Joe, Borchardt, Thomas B, Stowell, Joseph G, Byrn, Stephen R
Published in Journal of the American Chemical Society (02.02.2000)
Published in Journal of the American Chemical Society (02.02.2000)
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Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound—The Venetoclax Story
Emami Riedmaier, Arian, Lindley, David J., Hall, Jeffrey A., Castleberry, Steven, Slade, Russell T., Stuart, Patricia, Carr, Robert A., Borchardt, Thomas B., Bow, Daniel A.J., Nijsen, Marjoleen
Published in Journal of pharmaceutical sciences (01.01.2018)
Published in Journal of pharmaceutical sciences (01.01.2018)
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Novel Physics-Based Ensemble Modeling Approach That Utilizes 3D Molecular Conformation and Packing to Access Aqueous Thermodynamic Solubility: A Case Study of Orally Available Bromodomain and Extraterminal Domain Inhibitor Lead Optimization Series
Hong, Richard S, Mattei, Alessandra, Sheikh, Ahmad Y, Bhardwaj, Rajni Miglani, Bellucci, Michael A, McDaniel, Keith F, Pierce, M. Olivia, Sun, Guangxu, Li, Sizhu, Wang, Lingle, Mondal, Sayan, Ji, Jianguo, Borchardt, Thomas B
Published in Journal of chemical information and modeling (22.03.2021)
Published in Journal of chemical information and modeling (22.03.2021)
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Journal Article
A "hidden" co-crystal of caffeine and adipic acid
Bucar, Dejan-Kresimir, Henry, Rodger F, Lou, Xiaochun, Borchardt, Thomas B, Zhang, Geoff G Z
Published in Chemical communications (Cambridge, England) (01.01.2007)
Published in Chemical communications (Cambridge, England) (01.01.2007)
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Journal Article
Development of a Scalable Synthesis of Dipeptidyl Peptidase-4 Inhibitor ABT-279
McDermott, Todd S, Bhagavatula, Lakshmi, Borchardt, Thomas B, Engstrom, Kenneth M, Gandarilla, Jorge, Kotecki, Brian J, Kruger, Albert W, Rozema, Michael J, Sheikh, Ahmad Y, Wagaw, Seble H, Wittenberger, Steven J
Published in Organic process research & development (20.11.2009)
Published in Organic process research & development (20.11.2009)
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Journal Article
Chromoisomers and Polymorphs of 9-Phenylacridinium Hydrogen Sulfate
Toma, Pascal H, Kelley, Michael P, Borchardt, Thomas B, Byrn, Stephen R, Kahr, Bart
Published in Chemistry of materials (01.08.1994)
Published in Chemistry of materials (01.08.1994)
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Journal Article
Conformational Color Polymorphism and Control of Crystallization of 5‐Methyl‐2‐[(4‐methyl‐2‐nitrophenyl)amino]‐3‐thiophenecarbonitrile
He, Xiaorong, Griesser, Ulrich J., Stowell, Joseph G., Borchardt, Thomas B., Byrn, Stephen R.
Published in Journal of pharmaceutical sciences (01.03.2001)
Published in Journal of pharmaceutical sciences (01.03.2001)
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