Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’
Goodridge, Helen S., Reyes, Christopher N., Becker, Courtney A., Katsumoto, Tamiko R., Ma, Jun, Wolf, Andrea J., Bose, Nandita, Chan, Anissa S. H., Magee, Andrew S., Danielson, Michael E., Weiss, Arthur, Vasilakos, John P., Underhill, David M.
Published in Nature (London) (28.04.2011)
Published in Nature (London) (28.04.2011)
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Journal Article
Imprime PGG, a yeast β-glucan immunomodulator, has the potential to repolarize human monocyte-derived M2 macrophages to M1 phenotype
Chan, Anissa SH, Qiu, Xiaohong, Jonas, Adria, Patchen, Myra L, Bose, Nandita
Published in Journal for immunotherapy of cancer (06.11.2014)
Published in Journal for immunotherapy of cancer (06.11.2014)
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Journal Article
Abstract LB-225: Imprime PGG modulates the function of monocyte-derived M2 macrophages and dendritic cells to drive T-cell expansion
Chan, Anissa SH, Qiu, Xiaohong, Jonas, Adria, Kangas, Takashi, Ottoson, Nadine R., Bose, Nandita
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract A02: Imprime PGG modulates the myeloid component of the tumor microenvironment to coordinate an antitumor immune response
Fraser, Kathryn, Ottoson, Nadine, Qiu, Xiaohong, Chan, Anissa SH, Jonas, Adria, Kangas, Takashi, Graff, Jeremy, Bose, Nandita
Published in Cancer research (Chicago, Ill.) (01.02.2016)
Published in Cancer research (Chicago, Ill.) (01.02.2016)
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Journal Article
Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation
Chan, Anissa S H, Jonas, Adria Bykowski, Qiu, Xiaohong, Ottoson, Nadine R, Walsh, Richard M, Gorden, Keith B, Harrison, Ben, Maimonis, Peter J, Leonardo, Steven M, Ertelt, Kathleen E, Danielson, Michael E, Michel, Kyle S, Nelson, Mariana, Graff, Jeremy R, Patchen, Myra L, Bose, Nandita
Published in PloS one (03.11.2016)
Published in PloS one (03.11.2016)
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Abstract LB-228: Imprime PGG treatment elicits a coordinated antitumor immune response that triggers enhanced expression of PD-L1 on tumor cells as well as monocyte-derived macrophages and dendritic cells
Bose, Nandita, Chan, Anissa SH, Jonas, Adria, Qiu, Xiaohong, Ottoson, Nadine R., Kangas, Takashi, Graff, Jeremy R.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract A3: Imprime PGG triggers a coordinated anti-cancer immune response in concert with anti-angiogenic antibodies, re-polarizing the immune microenvironment to suppress tumor growth
Fraser, Kathryn, Ottoson, Nadine, Qiu, Xiahong, Chan, Anissa SH, Jonas, Adria, Kangas, Takashi, Graff, Jeremy, Bose, Nandita
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Abstract B009: Imprime PGG, a soluble yeast b-glucan PAMP, activates both innate and adaptive immune effector cells, resulting in enhanced antitumor responses that synergize with anti-PD-1 antibody therapy
Leonardo, Steven, Fulton, Ross B., Fraser, Kathryn A., Kangas, Takashi O., Gorden, Keith B., Harrison, Ben, Jonas, Adria LB, Chan, Anissa SH, Yokayama, Yumi, Bose, Nandita, Graff, Jeremy R., Uhlik, Mark
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
Abstract LB-199: Imprime PGG modulates immunosuppressive myeloid components of the tumor microenvironment and drives enhanced antitumor efficacy in combination with checkpoint inhibitor therapies
Jonas, Adria B., Chan, Anissa SH, Qiu, Xiaohong, Fraser, Kathryn, Ottoson, Nadine, Kangas, Takashi, Walsh, Richard, Leonardo, Steven M., Fulton, Ross, Gorden, Keith, Uhlik, Mark, Graff, Jeremy, Bose, Nandita
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract LB-089: Imprime PGG, a -glucan PAMP (pathogen-associated molecular pattern), effectively elicits in vivo maturation of antigen presenting cells in mice and humans, suggesting potential synergy with checkpoint inhibitor therapy
Fulton, Ross B, Leonardo, Steven M, Jonas, Adria B, Fraser, Kathryn A, Chan, Anissa SH, Ottoson, Nadine R, Danielson, Michael E, Bose, Nandita, Graff, Jeremy R, Gorden, Keith
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract LB-087: Imprime PGG drives adaptive immune resistance within the tumor microenvironment by modulating the myeloid compartment and enhances the efficacy of anti-PD1 antibody in vivo
Bykowski Jonas, Adria L., Chan, Anissa SH, Ottoson, Nadine R., Qiu, Xiaohong, Fraser, Kathryn, Kangas, Takashi O., Fulton, Ross, Rathmann, Blaine, Graff, Jeremy R., Bose, Nandita
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract A30: Activation of GCN2 by HC-7366 results in significant anti-tumor efficacy as monotherapy and in combination with Venetoclax in AML models
Tameire, Feven, Wojnarowicz, Paulina M., Fujisawa, Sho, Huang, Sharon, Reilly, Owen, Dudgeon, Crissy, Collette, Nicholas, Drees, Jeremy, Bieging-Rolett, Kathryn, Kangas, Takashi O, Zhang, Weiyu, Fumagalli, Maria, Dewji, Iman, Li, Yunfang, Chan, Anissa SH, Qiu, Xiaohong, Harrison, Ben, LaCayo, Ashley, Staschke, Kirk A., Rigby, Alan C., Ramurthy, Savithri, Lightcap, Eric S., Surguladze, David, Bose, Nandita
Published in Blood cancer discovery (01.05.2023)
Published in Blood cancer discovery (01.05.2023)
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Abstract 6231: Activation of GCN2 by HC-7366 results in significant antitumor efficacy as monotherapy and in combination with multiple standard of care agents in various solid cancer models
Tameire, Feven, Wojnarowicz, Paulina, Dudgeon, Crissy, Fujisawa, Sho, Huang, Sharon, Reilly, Owen B., Collette, Nicholas, Drees, Jeremy, Bieging-Rolett, Kathryn, Kangas, Takashi O., Zhang, Weiyu, Fumagalli, Maria, Dewji, Iman, Li, Yunfang, Chan, Anissa SH, Qiu, Xiaohong, Harrison, Ben, LaCayo, Ashley, Cordova, Ricardo A., Staschke, Kirk A., Rigby, Alan C., Ramurthy, Savithri, Lightcap, Eric S., Surguladze, David, Bose, Nandita
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract A99: Imprime PGG, a soluble yeast β-glucan, induces dendritic cell maturation, upregulating co-stimulatory and activation markers to enhance antigen presentation and T cell priming
Fulton, Ross B., Chan, Anissa SH, Leonardo, Steven M., Jonas, Adria B., Qiu, Xiaohong, Ottoson, Nadine C., Kangas, Takashi O., Michel, Kyle S., Danielson, Michael E., Graff, Jeremy R., Bose, Nandita, Gorden, Keith
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Abstract 5627: Antitumor activity of soluble beta-1,3/1,6 glucans: Structure matters
Vasilakos, John P., Bose, Nandita, Chan, Anissa SH, Danielson, Michael E., Elmasry, Natalie, Gorden, Keith B., Guerrero, Faimola O., Magee, Andy, Maristany, Carolyn M., Walsh, Richard M., Will, Paul M., Wurst, Lindsay R.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
884 PERK inhibitor HC-5404 demonstrates immune-activation and anti-tumor efficacy in combination with anti-PD1 immune checkpoint inhibitor antibody
Anissa SH Chan, Drees, Jeremy, Li, Yunfang, Kangas, Takashi, Zhang, Weiyu, Fumagalli, Maria, Dewji, Iman, Qiu, Xiaohong, Collette, Nick, Harrison, Ben, LaCayo, Ashley, Veronica Calvo Vidal, Dudgeon, Crissy, Stokes, Michael, Lightcap, Eric, Surguladze, David, Bose, Nandita
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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