Development of ADS051, an oral, gut‐restricted, small molecule neutrophil modulator for the treatment of neutrophil‐mediated inflammatory diseases
Murphy, Christopher K., Dixit, Bharat, Oleson, Frederick B., Dolle, Roland E., Farquhar, Ronald, McCormick, Beth A.
Published in FEBS open bio (01.08.2023)
Published in FEBS open bio (01.08.2023)
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A novel dual NLRP1 and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases
Docherty, Callum Ah, Fernando, Anuruddika J, Rosli, Sarah, Lam, Maggie, Dolle, Roland E, Navia, Manuel A, Farquhar, Ronald, La France, Danny, Tate, Michelle D, Murphy, Christopher K, Rossi, Adriano G, Mansell, Ashley
Published in Clinical & translational immunology (01.01.2023)
Published in Clinical & translational immunology (01.01.2023)
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Journal Article
The selective mu-opioid receptor antagonist adl5510 reduces levodopa-induced dyskinesia without affecting antiparkinsonian action in mptp-lesioned macaque model of Parkinson's disease
Koprich, James B., Fox, Susan H., Johnston, Tom H., Goodman, Allan, Le Bourdonnec, Bertrand, Dolle, Roland E., DeHaven, Robert N., DeHaven-Hudkins, Diane L., Little, Patrick J., Brotchie, Jonathan M.
Published in Movement disorders (01.06.2011)
Published in Movement disorders (01.06.2011)
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Journal Article
Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy
Oh, Young Mi, Lee, Seong Won, Kim, Woo Kyung, Chen, Shawei, Church, Victoria A., Cates, Kitra, Li, Tiandao, Zhang, Bo, Dolle, Roland E., Dahiya, Sonika, Pak, Stephen C., Silverman, Gary A., Perlmutter, David H., Yoo, Andrew S.
Published in Nature neuroscience (01.11.2022)
Published in Nature neuroscience (01.11.2022)
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Journal Article
Discovery of 6‑Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases
Dang, Xiawei, Zhang, Lihong, Franco, Antonietta, Li, Jiajia, Rocha, Agostinho G, Devanathan, Sriram, Dolle, Roland E, Bernstein, Peter R, Dorn, Gerald W
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization
Nozaki, Chihiro, Le Bourdonnec, Bertrand, Reiss, David, Windh, Rolf T, Little, Patrick J, Dolle, Roland E, Kieffer, Brigitte L, Gavériaux-Ruff, Claire
Published in The Journal of pharmacology and experimental therapeutics (01.09.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2012)
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Journal Article
Correction to “Discovery of 6‑Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases”
Dang, Xiawei, Zhang, Lihong, Franco, Antonietta, Li, Jiajia, Rocha, Agostinho G, Devanathan, Sriram, Dolle, Roland E, Bernstein, Peter R, Dorn, Gerald W
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Journal Article
Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints
Chu, Guo-Hua, Gu, Minghua, Cassel, Joel A., Belanger, Serge, Graczyk, Thomas M., DeHaven, Robert N., Conway-James, Nathalie, Koblish, Mike, Little, Patrick J., DeHaven-Hudkins, Diane L., Dolle, Roland E.
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
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Journal Article
Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors
Zhang, Jing, Yang, Qingyi, Cross, Jason B, Romero, Jan Antoinette C, Poutsiaka, Katherine M, Epie, Felix, Bevan, Douglas, Wang, Bin, Zhang, Yanzhi, Chavan, Ajit, Zhang, Xin, Moy, Terence, Daniel, Anu, Nguyen, Kien, Chamberlain, Brian, Carter, Nicole, Shotwell, Joseph, Silverman, Jared, Metcalf, Chester A, Ryan, Dominic, Lippa, Blaise, Dolle, Roland E
Published in Journal of medicinal chemistry (12.11.2015)
Published in Journal of medicinal chemistry (12.11.2015)
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Journal Article
Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design
Cross, Jason B, Zhang, Jing, Yang, Qingyi, Mesleh, Michael F, Romero, Jan Antoinette C, Wang, Bin, Bevan, Doug, Poutsiaka, Katherine M, Epie, Felix, Moy, Terence, Daniel, Anu, Shotwell, Joseph, Chamberlain, Brian, Carter, Nicole, Andersen, Ole, Barker, John, Ryan, M. Dominic, Metcalf, Chester A, Silverman, Jared, Nguyen, Kien, Lippa, Blaise, Dolle, Roland E
Published in ACS medicinal chemistry letters (14.04.2016)
Published in ACS medicinal chemistry letters (14.04.2016)
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Journal Article
Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)
Le Bourdonnec, Bertrand, Windh, Rolf T., Leister, Lara K., Zhou, Q. Jean, Ajello, Christopher W., Gu, Minghua, Chu, Guo-Hua, Tuthill, Paul A., Barker, William M., Koblish, Michael, Wiant, Daniel D., Graczyk, Thomas M., Belanger, Serge, Cassel, Joel A., Feschenko, Marina S., Brogdon, Bernice L., Smith, Steven A., Derelanko, Michael J., Kutz, Steve, Little, Patrick J., DeHaven, Robert N., DeHaven-Hudkins, Diane L., Dolle, Roland E.
Published in Journal of medicinal chemistry (24.09.2009)
Published in Journal of medicinal chemistry (24.09.2009)
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Journal Article
Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors
Zhang, Jing, Yang, Qingyi, Romero, Jan Antoinette C, Cross, Jason, Wang, Bin, Poutsiaka, Katherine M, Epie, Felix, Bevan, Douglas, Wu, Yuchuan, Moy, Terence, Daniel, Anu, Chamberlain, Brian, Carter, Nicole, Shotwell, Joseph, Arya, Anu, Kumar, Vipul, Silverman, Jared, Nguyen, Kien, Metcalf, Chester A, Ryan, Dominic, Lippa, Blaise, Dolle, Roland E
Published in ACS medicinal chemistry letters (08.10.2015)
Published in ACS medicinal chemistry letters (08.10.2015)
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Journal Article
Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)
Bourdonnec, Bertrand Le, Windh, Rolf T, Ajello, Christopher W, Leister, Lara K, Gu, Minghua, Chu, Guo-Hua, Tuthill, Paul A, Barker, William M, Koblish, Michael, Wiant, Daniel D, Graczyk, Thomas M, Belanger, Serge, Cassel, Joel A, Feschenko, Marina S, Brogdon, Bernice L, Smith, Steven A, Christ, David D, Derelanko, Michael J, Kutz, Steve, Little, Patrick J, DeHaven, Robert N, DeHaven-Hudkins, Diane L, Dolle, Roland E
Published in Journal of medicinal chemistry (09.10.2008)
Published in Journal of medicinal chemistry (09.10.2008)
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Journal Article
High-performance liquid chromatographic enantioseparation of methanobenzazocines
Barker, William M., Worm, Karin, Dolle, Roland E.
Published in Journal of Chromatography A (06.11.2009)
Published in Journal of Chromatography A (06.11.2009)
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Journal Article
Nascent structure–activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208
Dolle, Roland E., Michaut, Mathieu, Martinez-Teipel, Blanca, Seida, Pamela R., Ajello, Christopher W., Muller, Alison L., DeHaven, Robert N., Carroll, Patrick J.
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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