Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
Reaper, Philip M, Griffiths, Matthew R, Long, Joanna M, Charrier, Jean-Damien, MacCormick, Somhairle, Charlton, Peter A, Golec, Julian M C, Pollard, John R
Published in Nature chemical biology (13.04.2011)
Published in Nature chemical biology (13.04.2011)
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Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents
Charrier, Jean-Damien, Durrant, Steven J, Golec, Julian M. C, Kay, David P, Knegtel, Ronald M. A, MacCormick, Somhairle, Mortimore, Michael, O'Donnell, Michael E, Pinder, Joanne L, Reaper, Philip M, Rutherford, Alistair P, Wang, Paul S. H, Young, Stephen C, Pollard, John R
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Journal Article
A preliminary evaluation of a metathesis approach to bryostatins
Ball, Matthew, Bradshaw, Benjamin J., Dumeunier, Raphaël, Gregson, Thomas J., MacCormick, Somhairle, Omori, Hiroki, Thomas, Eric J.
Published in Tetrahedron letters (27.03.2006)
Published in Tetrahedron letters (27.03.2006)
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Rational Design of 5‑(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor
Knegtel, Ronald, Charrier, Jean-Damien, Durrant, Steven, Davis, Chris, O’Donnell, Michael, Storck, Pierre, MacCormick, Somhairle, Kay, David, Pinder, Joanne, Virani, Anisa, Twin, Heather, Griffiths, Matthew, Reaper, Philip, Littlewood, Peter, Young, Steve, Golec, Julian, Pollard, John
Published in Journal of medicinal chemistry (13.06.2019)
Published in Journal of medicinal chemistry (13.06.2019)
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Synthesis and cellular uptake of carbamoylated mannose derivatives
Elferink, Hidde, Geurts, Kim, Jue, Stijn, MacCormick, Somhairle, Veeneman, Gerrit, Boltje, Thomas J.
Published in Carbohydrate research (15.07.2019)
Published in Carbohydrate research (15.07.2019)
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Journal Article
Some limitations of an approach to the assembly of bryostatins by ring-closing metathesisElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ob00079k
Dumeunier, Raphaël, Gregson, Thomas, MacCormick, Somhairle, Omori, Hiroki, Thomas, Eric J
Year of Publication 28.03.2017
Year of Publication 28.03.2017
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Effective 1,5-, 1,6-and 1,7-remote stereocontrol in reactions of alkoxy- and hydroxy-substituted allylstannanes with aldehydes
Carey, John S., MacCormick, Somhairle, Stanway, Steven J., Teerawutgulrag, Aphiwat, Thomas, Eric J.
Published in Organic & biomolecular chemistry (21.05.2011)
Published in Organic & biomolecular chemistry (21.05.2011)
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Journal Article
Abstract 5491: Evaluation of the first potent and highly selective inhibitor of ATR kinase: An approach to selectively sensitize cancer cells to genotoxic drugs
Pollard, John R., Caron, Paul, Charlton, Peter, Charrier, Jean-Damien, Golec, Julian, Griffiths, Matthew, Hall, Amy, Hare, Brian, Long, Joanna, MacCormick, Somhairle, Milton, Sean, Murcko, Mark, Murphy, Cheryl, Peek, Adele, Reaper, Philip, Takemoto, Darin
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
Pyrazine derivatives useful as inhibitors of ATR kinase
DURRANT STEVEN, MORTIMORE MICHAEL, O'DONNELL MICHAEL, KAY DAVID, CHARRIER JEAN DAMIEN, YOUNG STEPHEN, REAPER PHILIP MICHAEL, PINDER JOANNE, KNEGTEL RONALD, RUTHERFORD ALISTAIR, VIRANI ANISA NIZARALI, MACCORMICK SOMHAIRLE
Year of Publication 12.07.2017
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Year of Publication 12.07.2017
Patent
NOVEL HISTONE DEACETYLASE INHIBITORS
CECIL ALEXANDER RICHARD LIAM, SHUTTLEWORTH STEPHEN JOSEPH, TOMASSI CYRILLE DAVY, NODES WILLIAM JOHN, MACCORMICK SOMHAIRLE, SILVA FRANCK ALEXANDRE
Year of Publication 20.01.2016
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Year of Publication 20.01.2016
Patent
A stereoselective synthesis of the C(1)–C(16) fragment of the bryostatins
Ball, Matthew, Baron, Anne, Bradshaw, Benjamin, Omori, Hiroki, MacCormick, Somhairle, Thomas, Eric J.
Published in Tetrahedron letters (15.11.2004)
Published in Tetrahedron letters (15.11.2004)
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Compounds useful as Inhibitors of ATR kinase
O'DONNELL MICHAEL, YOUNG STEPHEN, FANNING LEV T.D, CLEVELAND THOMAS, VIRANI ANISA, MACCORMICK SOMHAIRLE, BINCH HAYLEY, DURRANT STEVEN, HURLEY DENNIS, SHETH URVI, KAY DAVID, SILINA ALINA, CHARRIER JEAN DAMIEN, REAPER PHILIP MICHAEL, PINDER JOANNE, KNEGTEL RONALD, JOSHI PRAMOD
Year of Publication 08.02.2017
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Year of Publication 08.02.2017
Patent
Remote stereocontrol using ( E)-6-hydroxy-4-methylhex-2-enyl(tri- n-butyl)stannane
MacCormick, Somhairle, Thomas, Eric J.
Published in Journal of organometallic chemistry (01.04.2006)
Published in Journal of organometallic chemistry (01.04.2006)
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