Discovery of 2-((R)-4-(2-Fluoro-4-(methylsulfonyl)phenyl)-2-methylpiperazin-1-yl)-N-((1R,2s,3S,5S,7S)-5-hydroxyadamantan-2-y1)pyrimidine-4-carboxamide (SKI2852): A Highly Potent, Selective, and Orally Bioavailable Inhibitor of 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1)
Ryu, Je Ho, Lee, Jung A., Kim, Shinae, Shin, Young Ah, Yang, Jewon, Han, Hye Young, Son, Hyun Joo, Kim, Yong Hyuk, Sa, Joon Ho, Kim, Jae-Sun, Lee, Jungeun, Lee, Jeeyeon, Park, Hyeung-geun
Published in Journal of medicinal chemistry (24.11.2016)
Published in Journal of medicinal chemistry (24.11.2016)
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Journal Article
Discovery of 2‑((R)‑4-(2-Fluoro-4-(methylsulfonyl)phenyl)-2-methylpiperazin-1-yl)‑N‑((1R,2s,3S,5S,7S)‑5-hydroxyadamantan-2-yl)pyrimidine-4-carboxamide (SKI2852): A Highly Potent, Selective, and Orally Bioavailable Inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1)
Ryu, Je Ho, Lee, Jung A, Kim, Shinae, Shin, Young Ah, Yang, Jewon, Han, Hye Young, Son, Hyun Joo, Kim, Yong Hyuk, Sa, Joon Ho, Kim, Jae-Sun, Lee, Jungeun, Lee, Jeeyeon, Park, Hyeung-geun
Published in Journal of medicinal chemistry (23.11.2016)
Published in Journal of medicinal chemistry (23.11.2016)
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A potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, SKI2852, ameliorates metabolic syndrome in diabetic mice models
Oh, Hyunhee, Jeong, Kyeong-Hoon, Han, Hye Young, Son, Hyun Joo, Kim, Su Sung, Lee, Hyun Jung, Kim, Shinae, Sa, Joon Ho, Jun, Hee-Sook, Ryu, Je Ho, Choi, Cheol Soo
Published in European journal of pharmacology (05.12.2015)
Published in European journal of pharmacology (05.12.2015)
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Inhibitory effects of SKI3246, the rhizome extract of Atractylodes japonica, on visceral hypersensitivity in experimental irritable bowel syndrome rat models
Son, Hyun Joo, Jung, Kiwon, Park, Yang Hae, Jeon, Hyo Jin, Kang, Minseok, Ryu, Keun Ho, Pyo, Sung Soo, Eutamene, Helene, Bueno, Lionel, Sun, Won Suk
Published in Archives of pharmacal research (01.05.2015)
Published in Archives of pharmacal research (01.05.2015)
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