Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer
Brindani, Nicoletta, Vuong, Linh M., Acquistapace, Isabella Maria, La Serra, Maria Antonietta, Ortega, José Antonio, Veronesi, Marina, Bertozzi, Sine Mandrup, Summa, Maria, Girotto, Stefania, Bertorelli, Rosalia, Armirotti, Andrea, Ganesan, Anand K., De Vivo, Marco
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5
Brusa, Irene, Sondo, Elvira, Pesce, Emanuela, Tomati, Valeria, Gioia, Dario, Falchi, Federico, Balboni, Beatrice, Ortega Martínez, Jose Antonio, Veronesi, Marina, Romeo, Elisa, Margaroli, Natasha, Recanatini, Maurizio, Girotto, Stefania, Pedemonte, Nicoletta, Roberti, Marinella, Cavalli, Andrea
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells
Ortega, Jose Antonio, Arencibia, Jose M, La Sala, Giuseppina, Borgogno, Marco, Bauer, Inga, Bono, Luca, Braccia, Clarissa, Armirotti, Andrea, Girotto, Stefania, Ganesan, Anand, De Vivo, Marco
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer
Myers, Samuel H., Poppi, Laura, Rinaldi, Francesco, Veronesi, Marina, Ciamarone, Andrea, Previtali, Viola, Bagnolini, Greta, Schipani, Fabrizio, Ortega Martínez, Jose Antonio, Girotto, Stefania, Di Stefano, Giuseppina, Farabegoli, Fulvia, Walsh, Naomi, De Franco, Francesca, Roberti, Marinella, Cavalli, Andrea
Published in European journal of medicinal chemistry (05.02.2024)
Published in European journal of medicinal chemistry (05.02.2024)
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Predictors of inappropriate antimicrobial prescription: Eight-year point prevalence surveys experience in a third level hospital in Spain
Núñez-Núñez, María, Perez-Galera, Salvador, Girón-Ortega, José Antonio, Sandoval Fernández-Del-Castillo, Santiago, Beltrán-García, Margarita, De Cueto, Marina, Suárez-Barrenechea, Ana Isabel, Palacios-Baena, Zaira R., Terol-Barrero, Pedro, Oltra-Hostalet, Fernando, Arenzana-Seisdedos, Ángel, Rodriguez-Baño, Jesús, Retamar-Gentil, Pilar
Published in Frontiers in pharmacology (10.10.2022)
Published in Frontiers in pharmacology (10.10.2022)
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Journal Article
Synthetic Lethality through the Lens of Medicinal Chemistry
Myers, Samuel H, Ortega, Jose Antonio, Cavalli, Andrea
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Journal Article
Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
de la Roche, Noelia Montel, Mühlethaler, Tobias, Di Martino, Rita Maria Concetta, Ortega, Jose Antonio, Gioia, Dario, Roy, Bibhas, Prota, Andrea E., Steinmetz, Michel O., Cavalli, Andrea
Published in European journal of medicinal chemistry (05.11.2022)
Published in European journal of medicinal chemistry (05.11.2022)
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Journal Article
Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib
Bagnolini, Greta, Milano, Domenico, Manerba, Marcella, Schipani, Fabrizio, Ortega, Jose Antonio, Gioia, Dario, Falchi, Federico, Balboni, Andrea, Farabegoli, Fulvia, De Franco, Francesca, Robertson, Janet, Pellicciari, Roberto, Pallavicini, Isabella, Peri, Sebastiano, Minucci, Saverio, Girotto, Stefania, Di Stefano, Giuseppina, Roberti, Marinella, Cavalli, Andrea
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
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Journal Article
Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
Ortega, Jose Antonio, Riccardi, Laura, Minniti, Elirosa, Borgogno, Marco, Arencibia, Jose M, Greco, Maria L, Minarini, Anna, Sissi, Claudia, De Vivo, Marco
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Journal Article
Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy
Brindani, Nicoletta, Vuong, Linh M., La Serra, Maria Antonietta, Salvador, Noel, Menichetti, Andrea, Acquistapace, Isabella Maria, Ortega, Jose Antonio, Veronesi, Marina, Bertozzi, Sine Mandrup, Summa, Maria, Girotto, Stefania, Bertorelli, Rosalia, Armirotti, Andrea, Ganesan, Anand K., De Vivo, Marco
Published in Journal of medicinal chemistry (27.06.2024)
Published in Journal of medicinal chemistry (27.06.2024)
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Journal Article
Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β
Ortega, Jose Antonio, Arencibia, Jose M, Minniti, Elirosa, Byl, Jo Ann W, Franco-Ulloa, Sebastian, Borgogno, Marco, Genna, Vito, Summa, Maria, Bertozzi, Sine Mandrup, Bertorelli, Rosalia, Armirotti, Andrea, Minarini, Anna, Sissi, Claudia, Osheroff, Neil, De Vivo, Marco
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Journal Article
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N‑Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration
Di Fruscia, Paolo, Carbone, Anna, Bottegoni, Giovanni, Berti, Francesco, Giacomina, Francesca, Ponzano, Stefano, Pagliuca, Chiara, Fiasella, Annalisa, Pizzirani, Daniela, Ortega, Jose Antonio, Nuzzi, Andrea, Tarozzo, Glauco, Mengatto, Luisa, Giampà, Roberta, Penna, Ilaria, Russo, Debora, Romeo, Elisa, Summa, Maria, Bertorelli, Rosalia, Armirotti, Andrea, Bertozzi, Sine Mandrup, Reggiani, Angelo, Bandiera, Tiziano, Bertozzi, Fabio
Published in Journal of medicinal chemistry (23.09.2021)
Published in Journal of medicinal chemistry (23.09.2021)
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Journal Article
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure–activity relationship (SAR) studies
Nuzzi, Andrea, Fiasella, Annalisa, Ortega, Jose Antonio, Pagliuca, Chiara, Ponzano, Stefano, Pizzirani, Daniela, Bertozzi, Sine Mandrup, Ottonello, Giuliana, Tarozzo, Glauco, Reggiani, Angelo, Bandiera, Tiziano, Bertozzi, Fabio, Piomelli, Daniele
Published in European journal of medicinal chemistry (23.03.2016)
Published in European journal of medicinal chemistry (23.03.2016)
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Journal Article
Identification of RAD51–BRCA2 Inhibitors Using N‑Acylhydrazone-Based Dynamic Combinatorial Chemistry
Bagnolini, Greta, Balboni, Beatrice, Schipani, Fabrizio, Gioia, Dario, Veronesi, Marina, De Franco, Francesca, Kaya, Cansu, Jumde, Ravindra P., Ortega, Jose Antonio, Girotto, Stefania, Hirsch, Anna K. H., Roberti, Marinella, Cavalli, Andrea
Published in ACS medicinal chemistry letters (11.08.2022)
Published in ACS medicinal chemistry letters (11.08.2022)
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Journal Article
Psychological and Psychiatric Events Following Immunization with Five Different Vaccines against SARS-CoV-2
García-Alanis, Mario, Morales-Cárdenas, Marisa, Toapanta-Yanchapaxi, Liz Nicole, Chiquete, Erwin, Núñez, Isaac, Ceballos-Liceaga, Santa Elizabeth, Carbajal-Sandoval, Guillermo, Toledo-Salinas, Carla, Mendoza-Hernández, David Alejandro, Scheffler-Mendoza, Selma Cecilia, Ortega-Martell, José Antonio, Carrillo-García, Daniel Armando, Hernández-Valdivia, Noé, Gutiérrez-Romero, Alonso, Galnares-Olalde, Javier Andrés, Flores-Silva, Fernando Daniel, Díaz-Ortega, José Luis, Reyes-Terán, Gustavo, López-Gatell, Hugo, Cortes-Alcalá, Ricardo, Pérez-Padilla, José Rogelio, Arauz, Antonio, García-Grimshaw, Miguel, Valdés-Ferrer, Sergio Iván
Published in Vaccines (Basel) (01.08.2022)
Published in Vaccines (Basel) (01.08.2022)
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Significance and clinical outcome of lymph node level assessment in biliary tract cancers
Martínez-Galán, Joaquina, Soberino, Jesús, González Rivas, Cynthia S., Ruiz Vozmediano, Julia, Portellano, Lucia, Conde, Veronica, Ortega, Jose Antonio, Garcia, Javier, González Vicente, Aranzazu, Delgado, Juan Ramon
Published in Journal of clinical oncology (01.02.2013)
Published in Journal of clinical oncology (01.02.2013)
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Journal Article
Open, phase II randomized trial of gefitinib alone versus olaparib (AZD2281) plus gefitinib in advanced non-small cell lung cancer (NSCLC) patients (P) with epidermal growth factor receptor (EGFR) mutations: Spanish Lung Cancer Group trial (NCT=1513174/GECP-GOAL)
Massuti, Bartomeu, García Campelo, Rosario, Rodriguez Abreu, Delvys, Remon, Jordi, Majem, Margarita, Galvez, Elisa, Ortega, Jose Antonio, Aparisi, Francisco, Reguart, Noemi, Sala, María Ángeles, Isla, Dolores, Sanchez Ronco, Maria, Verdu, Ana, Molina-Vila, Miguel Angel, Mayo-de las Casas, Clara, Pereira, Eva, Cajal, Rosana, Gonzalez-Arenas, Maria Carmen, Carcereny, Enric, Rosell, Rafael
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
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Journal Article
An 19 F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer
Myers, Samuel H, Poppi, Laura, Rinaldi, Francesco, Veronesi, Marina, Ciamarone, Andrea, Previtali, Viola, Bagnolini, Greta, Schipani, Fabrizio, Ortega Martínez, Jose Antonio, Girotto, Stefania, Di Stefano, Giuseppina, Farabegoli, Fulvia, Walsh, Naomi, De Franco, Francesca, Roberti, Marinella, Cavalli, Andrea
Published in European journal of medicinal chemistry (05.02.2024)
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Published in European journal of medicinal chemistry (05.02.2024)
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