Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor
Man, Hon-Wah, Schafer, Peter, Wong, Lu Min, Patterson, Rebecca T, Corral, Laura G, Raymon, Heather, Blease, Kate, Leisten, Jim, Shirley, Michael A, Tang, Yang, Babusis, Darius M, Chen, Roger, Stirling, Dave, Muller, George W
Published in Journal of medicinal chemistry (26.03.2009)
Published in Journal of medicinal chemistry (26.03.2009)
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Journal Article
Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor
MAN, Hon-Wah, SCHAFER, Peter, BABUSIS, Darius M, CHEN, Roger, STIRLING, Dave, MULLER, George W, LU MIN WONG, PATTERSON, Rebecca T, CORRAL, Laura G, RAYMON, Heather, BLEASE, Kate, LEISTEN, Jim, SHIRLEY, Michael A, YANG TANG
Published in Journal of medicinal chemistry (26.03.2009)
Published in Journal of medicinal chemistry (26.03.2009)
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Journal Article
Enhancement of Cytokine Production and AP-1 Transcriptional Activity in T Cells by Thalidomide-Related Immunomodulatory Drugs
Schafer, Peter H, Gandhi, Anita K, Loveland, Michelle A, Chen, Roger S, Man, Hon-Wah, Schnetkamp, Paul P M, Wolbring, Gregor, Govinda, Sowmya, Corral, Laura G, Payvandi, Faribourz, Muller, George W, Stirling, David I
Published in The Journal of pharmacology and experimental therapeutics (01.06.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2003)
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Journal Article
Use of IMiD3, a Thalidomide Analog, as an Adjunct to Therapy for Experimental Tuberculous Meningitis
TSENOVA, Liana, MANGALISO, Bande, MULLER, George, YONG CHEN, FREEDMAN, Victoria H, STIRLING, David, KAPLAN, Gilla
Published in Antimicrobial Agents and Chemotherapy (01.06.2002)
Published in Antimicrobial Agents and Chemotherapy (01.06.2002)
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Structural Modifications of Thalidomide Produce Analogs with Enhanced Tumor Necrosis Factor Inhibitory Activity
Muller, George W, Corral, Laura G, Shire, Mary G, Wang, Hua, Moreira, Andre, Kaplan, Gilla, Stirling, David I
Published in Journal of medicinal chemistry (16.08.1996)
Published in Journal of medicinal chemistry (16.08.1996)
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A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos
Matyskiela, Mary E, Zhang, Weihong, Man, Hon-Wah, Muller, George, Khambatta, Godrej, Baculi, Frans, Hickman, Matthew, LeBrun, Laurie, Pagarigan, Barbra, Carmel, Gilles, Lu, Chin-Chun, Lu, Gang, Riley, Mariko, Satoh, Yoshitaka, Schafer, Peter, Daniel, Thomas O, Carmichael, James, Cathers, Brian E, Chamberlain, Philip P
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Protein Degradation via CRL4(CRBN) Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1
Hansen, Joshua D., Condroski, Kevin, Correa, Matthew, Muller, George, Man, Hon-Wah, Ruchelman, Alexander, Zhang, Weihong, Vocanson, Fan, Crea, Tim, Liu, Wei, Lu, Gang, Baculi, Frans, LeBrun, Laurie, Mahmoudi, Afshin, Carmel, Gilles, Hickman, Matt, Lu, Chin-Chun
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Journal Article
Protein Degradation via CRL4 CRBN Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1
Hansen, Joshua D, Condroski, Kevin, Correa, Matthew, Muller, George, Man, Hon-Wah, Ruchelman, Alexander, Zhang, Weihong, Vocanson, Fan, Crea, Tim, Liu, Wei, Lu, Gang, Baculi, Frans, LeBrun, Laurie, Mahmoudi, Afshin, Carmel, Gilles, Hickman, Matt, Lu, Chin-Chun
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Journal Article
Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure–Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1
Hansen, Joshua D, Condroski, Kevin, Correa, Matthew, Muller, George, Man, Hon-Wah, Ruchelman, Alexander, Zhang, Weihong, Vocanson, Fan, Crea, Tim, Liu, Wei, Lu, Gang, Baculi, Frans, LeBrun, Laurie, Mahmoudi, Afshin, Carmel, Gilles, Hickman, Matt, Lu, Chin-Chun
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Journal Article
N,N'-disubstituted guanidine high-potency sweeteners
Muller, George W, Walters, D. Eric, DuBois, Grant. E
Published in Journal of medicinal chemistry (01.02.1992)
Published in Journal of medicinal chemistry (01.02.1992)
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Journal Article
Compounded drugs of value in outpatient hospice and palliative care practice
McNulty, John P, Muller, George
Published in International journal of pharmaceutical compounding (01.05.2014)
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Published in International journal of pharmaceutical compounding (01.05.2014)
Journal Article
Carboxylic acid replacement structure-activity relationships in suosan type sweeteners. A sweet taste antagonist. 1
Muller, George W, Culberson, J. Chris, Roy, Glenn, Ziegler, Jeanette, Walters, D. Eric, Kellogg, Michael S, Schiffman, Susan S, Warwick, Zoe S
Published in Journal of medicinal chemistry (01.05.1992)
Published in Journal of medicinal chemistry (01.05.1992)
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Journal Article
Update on manging neuropathic pain
McNulty, Jack P, Muller, George
Published in International journal of pharmaceutical compounding (01.05.2009)
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Published in International journal of pharmaceutical compounding (01.05.2009)
Journal Article
Tetracaine lollipops for the suppression of extreme gag reflex in dental patients
Muller, George, Case, Tyler, Deen, Griffin L
Published in International journal of pharmaceutical compounding (01.09.2010)
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Published in International journal of pharmaceutical compounding (01.09.2010)
Journal Article
Diverse challenges in pediatric compounding: treating pulmonary hypertension, uncombable hair syndrome, and acanthamoeba keratitis
Muller, George, Young, Thomas W, Riana, Rachel, Caldwell, Delmar R
Published in International journal of pharmaceutical compounding (01.01.2010)
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Published in International journal of pharmaceutical compounding (01.01.2010)
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