Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus
Schafer, Peter H, Ye, Ying, Wu, Lei, Kosek, Jolanta, Ringheim, Garth, Yang, Zhihong, Liu, Liangang, Thomas, Michael, Palmisano, Maria, Chopra, Rajesh
Published in Annals of the rheumatic diseases (01.10.2018)
Published in Annals of the rheumatic diseases (01.10.2018)
Get full text
Journal Article
CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL
Hagner, Patrick R., Man, Hon-Wah, Fontanillo, Celia, Wang, Maria, Couto, Suzana, Breider, Mike, Bjorklund, Chad, Havens, Courtney G., Lu, Gang, Rychak, Emily, Raymon, Heather, Narla, Rama Krishna, Barnes, Leo, Khambatta, Gody, Chiu, Hsiling, Kosek, Jolanta, Kang, Jian, Amantangelo, Michael D., Waldman, Michelle, Lopez-Girona, Antonia, Cai, Ti, Pourdehnad, Michael, Trotter, Matthew, Daniel, Thomas O., Schafer, Peter H., Klippel, Anke, Thakurta, Anjan, Chopra, Rajesh, Gandhi, Anita K.
Published in Blood (06.08.2015)
Published in Blood (06.08.2015)
Get full text
Journal Article
Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity
Nakayama, Yumi, Kosek, Jolanta, Capone, Lori, Hur, Eun Mi, Schafer, Peter H, Ringheim, Garth E
Published in The Journal of immunology (1950) (01.10.2017)
Published in The Journal of immunology (1950) (01.10.2017)
Get full text
Journal Article
Lenalidomide downregulates the cell survival factor, interferon regulatory factor‐4, providing a potential mechanistic link for predicting response
Lopez‐Girona, Antonia, Heintel, Daniel, Zhang, Ling‐Hua, Mendy, Derek, Gaidarova, Svetlana, Brady, Helen, Bartlett, Justin Blake, Schafer, Peter H., Schreder, Martin, Bolomsky, Arnold, Hilgarth, Bernadette, Zojer, Niklas, Gisslinger, Heinz, Ludwig, Heinz, Daniel, Tom, Jäger, Ulrich, Chopra, Rajesh
Published in British journal of haematology (01.08.2011)
Published in British journal of haematology (01.08.2011)
Get full text
Journal Article
Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity
Gandhi, Anita K., Mendy, Derek, Waldman, Michelle, Chen, Gengxin, Rychak, Emily, Miller, Karen, Gaidarova, Svetlana, Ren, Yan, Wang, Maria, Breider, Michael, Carmel, Gilles, Mahmoudi, Afshin, Jackson, Pilgrim, Abbasian, Mahan, Cathers, Brian E., Schafer, Peter H., Daniel, Tom O., Lopez‐Girona, Antonia, Thakurta, Anjan, Chopra, Rajesh
Published in British journal of haematology (01.01.2014)
Published in British journal of haematology (01.01.2014)
Get full text
Journal Article
Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice
Schafer, Peter H., Adams, Mary, Horan, Gerald, Truzzi, Francesca, Marconi, Alessandra, Pincelli, Carlo
Published in Drugs in R&D (01.12.2019)
Published in Drugs in R&D (01.12.2019)
Get full text
Journal Article
Spebrutinib (CC-292) Affects Markers of B Cell Activation, Chemotaxis, and Osteoclasts in Patients with Rheumatoid Arthritis: Results from a Mechanistic Study
Schafer, Peter H., Kivitz, Alan J., Ma, Jianglin, Korish, Shimon, Sutherland, Donna, Li, Li, Azaryan, Ada, Kosek, Jolanta, Adams, Mary, Capone, Lori, Hur, Eun Mi, Hough, Douglas R., Ringheim, Garth E.
Published in Rheumatology and therapy. (01.03.2020)
Published in Rheumatology and therapy. (01.03.2020)
Get full text
Journal Article
Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells
VERHELLE, Dominique, CORRAL, Laura G, LOPEZ-GIRONA, Antonia, MUTTER, George W, BRADY, Helen A, CHAN, Kyle W. H, WONG, Kevin, MUELLER, Jessica H, MOUTOUH-DE PARSEVAL, Laure, JENSEN-PERGAKES, Kristen, SCHAFER, Peter H, CHEN, Roger, GLEZER, Emilia, FERGUSON, Gregory D
Published in Cancer research (Chicago, Ill.) (15.01.2007)
Published in Cancer research (Chicago, Ill.) (15.01.2007)
Get full text
Journal Article
The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions
Lu, Ling, Payvandi, Faribourz, Wu, Lei, Zhang, Ling-Hua, Hariri, Robert J, Man, Hon-Wah, Chen, Roger S., Muller, George W., Hughes, Christopher C.W., Stirling, David I., Schafer, Peter H., Bartlett, J. Blake
Published in Microvascular research (01.03.2009)
Published in Microvascular research (01.03.2009)
Get full text
Journal Article
Proteomic Correlates and Prognostic Significance of Kidney Injury in Heart Failure With Preserved Ejection Fraction
Salman, Oday, Zhao, Lei, Cohen, Jordana B, Dib, Marie Joe, Azzo, Joe David, Gan, Sushrima, Richards, A Mark, Pourmussa, Bianca, Doughty, Rob, Javaheri, Ali, Mann, Douglas L, Rietzschel, Ernst, Zhao, Manyun, Wang, Zhaoqing, Ebert, Christina, van Empel, Vanessa, Kammerhoff, Karl, Maranville, Joseph, Gogain, Joseph, Dennis, Jaclyn, Schafer, Peter H, Seiffert, Dietmar, Gordon, David A, Ramirez-Valle, Francisco, Cappola, Thomas P, Chirinos, Julio A
Published in Journal of the American Heart Association (03.09.2024)
Published in Journal of the American Heart Association (03.09.2024)
Get full text
Journal Article
Prognostic Significance and Biologic Associations of Senescence-Associated Secretory Phenotype Biomarkers in Heart Failure
Salman, Oday, Zamani, Payman, Zhao, Lei, Dib, Marie Joe, Gan, Sushrima, Azzo, Joe David, Pourmussa, Bianca, Richards, Arthur Mark, Javaheri, Ali, Mann, Douglas L, Rietzschel, Ernst, Zhao, Manyun, Wang, Zhaoqing, Ebert, Christina, Liu, Laura, Gunawardhana, Kushan L, Greenawalt, Danielle, Carayannopoulos, Leon, Chang, Ching-Pin, van Empel, Vanessa, Gogain, Joseph, Schafer, Peter H, Gordon, David A, Ramirez-Valle, Francisco, Cappola, Thomas P, Chirinos, Julio A
Published in Journal of the American Heart Association (03.09.2024)
Published in Journal of the American Heart Association (03.09.2024)
Get full text
Journal Article
Iberdomide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled, ascending-dose, phase 2a study
Furie, Richard A, Hough, Douglas R, Gaudy, Allison, Ye, Ying, Korish, Shimon, Delev, Nikolay, Weiswasser, Michael, Zhan, Xiaojiang, Schafer, Peter H, Werth, Victoria P
Published in Lupus science & medicine (01.02.2022)
Published in Lupus science & medicine (01.02.2022)
Get full text
Journal Article
Urinary Proteomics and Outcomes in Heart Failure With Preserved Ejection Fraction
Carland, Corinne, Zhao, Lei, Salman, Oday, Cohen, Jordana B, Zamani, Payman, Xiao, Qing, Dongre, Ashok, Wang, Zhaoqing, Ebert, Christina, Greenawalt, Danielle, van Empel, Vanessa, Richards, A Mark, Doughty, Robert N, Rietzschel, Ernst, Javaheri, Ali, Wang, Yixin, Schafer, Peter H, Hersey, Sarah, Carayannopoulos, Leonidas N, Seiffert, Dietmar, Chang, Ching-Pin, Gordon, David A, Ramirez-Valle, Francisco, Mann, Douglas L, Cappola, Thomas P, Chirinos, Julio A
Published in Journal of the American Heart Association (07.05.2024)
Published in Journal of the American Heart Association (07.05.2024)
Get full text
Journal Article
JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers
van der Velden, Jos L. J., Ye, Ying, Nolin, James D., Hoffman, Sidra M., Chapman, David G., Lahue, Karolyn G., Abdalla, Sarah, Chen, Peng, Liu, Yong, Bennett, Brydon, Khalil, Nasreen, Sutherland, Donna, Smith, William, Horan, Gerald, Assaf, Mahmoud, Horowitz, Zebulun, Chopra, Rajesh, Stevens, Randall M., Palmisano, Maria, Janssen-Heininger, Yvonne M. W., Schafer, Peter H.
Published in Clinical and translational medicine (02.09.2016)
Published in Clinical and translational medicine (02.09.2016)
Get full text
Journal Article
Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity
Ruchelman, Alexander L., Man, Hon-Wah, Zhang, Weihong, Chen, Roger, Capone, Lori, Kang, Jian, Parton, Anastasia, Corral, Laura, Schafer, Peter H., Babusis, Darius, Moghaddam, Mehran F., Tang, Yang, Shirley, Michael A., Muller, George W.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Get full text
Journal Article
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)
Gandhi, Anita K, Kang, Jian, Havens, Courtney G, Conklin, Thomas, Ning, Yuhong, Wu, Lei, Ito, Takumi, Ando, Hideki, Waldman, Michelle F, Thakurta, Anjan, Klippel, Anke, Handa, Hiroshi, Daniel, Thomas O, Schafer, Peter H, Chopra, Rajesh
Published in British journal of haematology (01.03.2014)
Published in British journal of haematology (01.03.2014)
Get full text
Journal Article
Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus
Merrill, Joan T, Werth, Victoria P, Furie, Richard, van Vollenhoven, Ronald, Dörner, Thomas, Petronijevic, Milan, Velasco, Jorge, Majdan, Maria, Irazoque-Palazuelos, Fedra, Weiswasser, Michael, Korish, Shimon, Ye, Ying, Gaudy, Allison, Schafer, Peter H, Liu, Zhaohui, Agafonova, Nataliya, Delev, Nikolay
Published in The New England journal of medicine (17.03.2022)
Published in The New England journal of medicine (17.03.2022)
Get full text
Journal Article
Lenalidomide efficacy in activated B‐cell‐like subtype diffuse large B‐cell lymphoma is dependent upon IRF4 and cereblon expression
Zhang, Ling‐Hua, Kosek, Jolanta, Wang, Maria, Heise, Carla, Schafer, Peter H., Chopra, Rajesh
Published in British journal of haematology (01.02.2013)
Published in British journal of haematology (01.02.2013)
Get full text
Journal Article