PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-1-(3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL) N-METHYL METHANAMINE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF
GONZALEZ SABIN JAVIER, MORIS VARAS FRANCISCO, LEFOULON FRANCOIS, PEDRAGOSA MOREAU SANDRINE
Year of Publication 27.01.2014
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Year of Publication 27.01.2014
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Visualization of enzyme-catalyzed reactions using pH indicators: rapid screening of hydrolase libraries and estimation of the enantioselectivity
Morís-Varas, F, Shah, A, Aikens, J, Nadkarni, N P, Rozzell, J D, Demirjian, D C
Published in Bioorganic & medicinal chemistry (01.10.1999)
Published in Bioorganic & medicinal chemistry (01.10.1999)
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Journal Article
Synthesis of sialyl Lewis x mimetics as selectin inhibitors by enzymatic aldol condensation reactions
Lin, C C, Morís-Varas, F, Weitz-Schmidt, G, Wong, C H
Published in Bioorganic & medicinal chemistry (01.03.1999)
Published in Bioorganic & medicinal chemistry (01.03.1999)
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Journal Article
PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-1-(3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL) N-METHYL METHANAMINE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF
Sandrine PEDRAGOSA MOREAU, Francisco MORIS VARAS, Javier GONZALEZ SABIN, Francois LEFOULON
Year of Publication 07.09.2020
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Year of Publication 07.09.2020
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Actividad antitumoral de inhibidores de multicinasas en cáncer colorrectal
MORIS VARAS, Francisco, OCANA FERNANDEZ, Alberto, PANDIELLA ALONSO, Atanasio
Year of Publication 19.01.2021
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Year of Publication 19.01.2021
Patent
ΜΕΘΟΔΟΣ ΕΝΖΥΜΑΤΙΚΗΣ ΣΥΝΘΕΣΗΣ TOY (7S)-1-(3,4-ΔΙΜΕΘΟΞΥΔΙΚΥΚΛΟ[4.2.0] ΟΚΤΑ-1,3,5-ΤΡΙΕΝ-7-ΥΛ)-Ν-ΜΕΘΥΛΟΜΕΘΑΝΑΜΙΝΗΣ ΚΑΙ ΕΦΑΡΜΟΓΗ ΣΤΗ ΣΥΝΘΕΣΗ ΤΗΣ ΙΒΑΒΡΑΔΙΝΗΣ ΚΑΙ ΤΩΝ ΑΛΑΤΩΝ ΑΥΤΗΣ
PEDRAGOSA MOREAU Sandrine, LEFOULON François, MORIS VARAS Francisco, GONZALEZ SABIN Javier
Year of Publication 15.03.2017
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Year of Publication 15.03.2017
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Process for the enzymatic synthesis of (7S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl) N-methyl methanamine, and application in the synthesis of ivabradine and salts thereof
MORIS VARAS, Francisco, PEDRAGOSA MOREAU, Sandrine, GONZALEZ SABIN, Javier, LEFOULON, Francois
Year of Publication 02.02.2017
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Year of Publication 02.02.2017
Patent
PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-1-(3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL) N-METHYL METHANAMINE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF
PEDRAGOSA-MOREAU Sandrine, LEFOULON Francois, MORIS VARAS Francisco, GONZALEZ SABIN Javier
Year of Publication 31.10.2016
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Year of Publication 31.10.2016
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ENZYMATIC SYNTHESIS PROCESS FOR (7S)-1-(3,4-DIMETHOXY BICYCLO[4.2.0]OCTA-1,3,5-TRIENE 7-YL) N-METHYL METHANAMINE, AND APPLICATION TO THE SYNTHESIS OF IVABRADINE AND OF ITS SALTS
PEDRAGOSA MOREAU, SANDRINE, GONZALEZ SABIN, JAVIER, LEFOULON, FRANCOIS, MORIS VARAS, FRANCISCO
Year of Publication 22.03.2016
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Year of Publication 22.03.2016
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Method for enzymatic synthesis of (7S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-yl) N-methyl methanamine, and use for the synthesis of Ivabradine and the salts thereof
Moris Varas, Francisco, Gonzalez Sabin, Javier, Lefoulon, François, Pedragosa Moreau, Sandrine
Year of Publication 29.02.2016
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Year of Publication 29.02.2016
Patent
METHOD FOR ENZYMATIC SYNTHESIS OF (7S)-1-(3,4-DIMETHOXYBICYCLO [4.2.0]OCTA-1,3,5-TRIENE-7-YL)N-METHYL METHANAMINE AND APPLICATION THEREIN IVABRADINE SYNTHESIS
MORIS VARAS, JAVIER, LEFOULON, FRANÇOIS, MOREAU, SANDRINE PEDRAGOSA, MORIS VARAS, FRANCISCO
Year of Publication 11.01.2016
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Year of Publication 11.01.2016
Patent
Method for enzymatic synthesis of (7S)-1-(3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-triene-7-yl) N-methyl methanamine, and use for the synthesis of Ivabradine and the salts thereof
GONZALEZ SABIN JAVIER, MORIS VARAS FRANCISCO, LEFOULON FRANCOIS, PEDRAGOSA MOREAU SANDRINE
Year of Publication 30.11.2015
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Year of Publication 30.11.2015
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Process for the enzymatic synthesis of (7S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methyl-methanamine and application in the synthesis of ivabradine and salts thereof
GONZALEZ SABIN JAVIER, MORIS VARAS FRANCISCO, LEFOULON FRANCOIS, PEDRAGOSA MOREAU SANDRINE
Year of Publication 31.10.2015
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Year of Publication 31.10.2015
Patent
Method for enzymatic synthesis of (7S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-yl) N-methyl methanamine, and use for the synthesis of Ivabradine and the salts thereof
PEDRAGOSA MOREAU, SANDRINE, GONZALEZ SABIN, JAVIER, LEFOULON, FRANÇOIS, MORIS VARAS, FRANCISCO
Year of Publication 30.10.2015
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Year of Publication 30.10.2015
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METHOD FOR ENZYMATIC SYNTHESIS OF (7S)-1-(3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIENE-7-YL) N-METHYL METHANAMINE, AND USE FOR THE SYNTHESIS OF IVABRADINE AND THE SALTS THEREOF
MORIS, VARAS FRANCISCO, PEDRAGOSA, MOREAU SANDRINE, LEFOULON, FRANÇOIS, GONZALEZ, SABIN JAVIER
Year of Publication 30.10.2015
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Year of Publication 30.10.2015
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Fremgangsmåde til enzymatisk syntese af (7s)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-n-methylmethanamin og anvendelse til syntese af ivabradin og salte deraf
PEDRAGOSA MOREAU, SANDRINE, GONZALEZ SABIN, JAVIER, LEFOULON, FRANÇOIS, MORIS VARAS, FRANCISCO
Year of Publication 28.09.2015
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Year of Publication 28.09.2015
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METHOD FOR ENZYMATIC SYNTHESIS OF (7S)-1-(3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIENE-7-YL) N-METHYL METHANAMINE, AND USE FOR THE SYNTHESIS OF IVABRADINE AND THE SALTS THEREOF
PEDRAGOSA MOREAU, SANDRINE, GONZALEZ SABIN, JAVIER, LEFOULON, FRANÇOIS, MORIS VARAS, FRANCISCO
Year of Publication 25.09.2015
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Year of Publication 25.09.2015
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METHOD FOR ENZYMATIC SYNTHESIS OF (7S)-1-(3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIENE-7-YL) N-METHYL METHANAMINE, AND USE FOR THE SYNTHESIS OF IVABRADINE AND THE SALTS THEREOF
FRANÇOIS LEFOULON, JAVIER GONZALEZ SABIN, SANDRINE PEDRAGOSA MOREAU, FRANCISCO MORIS VARAS
Year of Publication 11.08.2015
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Year of Publication 11.08.2015
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Method for enzymatic synthesis of (7S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-yl) N-methyl methanamine, and use for the synthesis of Ivabradine and the salts thereof
PEDRAGOSA MOREAU, SANDRINE, GONZALEZ SABIN, JAVIER, LEFOULON, FRANÇOIS, MORIS VARAS, FRANCISCO
Year of Publication 24.06.2015
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Year of Publication 24.06.2015
Patent