Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy
Chen, Qing, Xie, Weilin, Kuhn, Deborah J., Voorhees, Peter M., Lopez-Girona, Antonia, Mendy, Derek, Corral, Laura G., Krenitsky, Veronique Plantevin, Xu, Weiming, Moutouh-de Parseval, Laure, Webb, David R., Mercurio, Frank, Nakayama, Keiichi I., Nakayama, Keiko, Orlowski, Robert Z.
Published in Blood (01.05.2008)
Published in Blood (01.05.2008)
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Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases
Xu, Yibing, Li, Jianwu, Ferguson, Gregory D., Mercurio, Frank, Khambatta, Gody, Morrison, Lisa, Lopez-Girona, Antonia, Corral, Laura G., Webb, David R., Bennett, Brydon L., Xie, Weilin
Published in Blood (09.07.2009)
Published in Blood (09.07.2009)
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BTX-1188, a first-in-class dual degrader of GSPT1 and IKZF1/3, for treatment of acute myeloid leukemia (AML) and solid tumors
Chourasia, Aparajita Hoskote, Majeski, Hannah, Pasis, Angela, Erdman, Paul, Oke, Ashwini, Hecht, David, Lonergan, David, Mercurio, Frank, Chan, Kyle, Thai, Dung Luong, Fung, Leah
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Abstract 1963: Targeting hematological malignancies with two functionally and mechanistically distinct classes of cereblon mediated protein homeostatic modulators
Chourasia, Aparajita Hoskote, Fung, Leah, Pasis, Angela, McElwee, Brooke, Schoolmeesters, Angela, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle W., Mercurio, Frank, Stirling, David I.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Bioavailable Dual-Protein Degraders of CK1α and Transcriptional Kinase CDK9 As Potential Therapeutics for Hematological Malignancies
Fung, Leah, Chourasia, Aparajita Hoskote, Torres, Eduardo, Lam, Imelda, Erdman, Paul, Hecht, David, Sullivan, Robert, McElwee, Brooke, Richard, Normand, Venkatachalam, Avanthika, Snir-Alkalay, Irit, Chan, Kyle WH, Mercurio, Frank, Ben-Neriah, Yinon, Stirling, David I
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Targeting AML: The Development of Two Functionally and Mechanistically Distinct Classes of Cereblon-Mediated Protein Homeostatic Modulators
Chourasia, Aparajita Hoskote, Fung, Leah, McElwee, Brooke, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle WH, Mercurio, Frank, Stirling, David I
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Targeting the Transcriptional Addiction of Leukemia Stem Cells By a New Class of Protein Kinase Inhibitors
Ben-Neriah, Yinon, Venkatachalam, Avanthika, Fink, Avner, Hung, Eric, Vacca, Joseph, Mercurio, Frank, Oren, Moshe, Pikarsky, Eli, Snir-Alkalay, Irit, Minzel, Waleed
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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The novel protein homeostatic modulator BTX306 is active in myeloma and overcomes bortezomib and lenalidomide resistance
Zou, Jianxuan, Jones, Richard J., Wang, Hua, Kuiatse, Isere, Shirazi, Fazal, Manasanch, Elisabet E., Lee, Hans C., Sullivan, Robert, Fung, Leah, Richard, Normand, Erdman, Paul, Torres, Eduardo, Hecht, David, Lam, Imelda, McElwee, Brooke, Chourasia, Aparajita H., Chan, Kyle W. H., Mercurio, Frank, Stirling, David I., Orlowski, Robert Z.
Published in Journal of molecular medicine (Berlin, Germany) (01.08.2020)
Published in Journal of molecular medicine (Berlin, Germany) (01.08.2020)
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Journal Article
Protein Homeostatic Modulators, a Novel Class of Cereblon-Targeting Small Molecules As Potential Clinical Candidates in Multiple Myeloma
Zou, Jianxuan, Jones, Richard J., Mertz, Janet E., Wang, Hua, Kuiatse, Isere, Sullivan, Bob, Fung, Leah, Richard, Normand, Erdman, Paul, Torres, Eduardo, Chourasia, Aparajita Hoskote, Chan, Kyle WH, Mercurio, Frank, Stirling, David I, Orlowski, Robert Z.
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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단백질 표적 화합물, 이의 약학 조성물 및 이들의 치료적 적용
CHAN KYLE W.H, CHOURASIA APARAJITA HOSKOTE, HECHT DAVID AARON, TORRES EDUARDO, LAM IMELDA, MERCURIO FRANK, SULLIVAN ROBERT, ERDMAN PAUL E, FUNG LEAH
Year of Publication 02.03.2022
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Year of Publication 02.03.2022
Patent
단백질 표적화에 사용하기 위한 티에노피롤 유도체, 조성물, 방법 및 이의 용도
CHAN KYLE W. H, TORRES EDUARDO, MERCURIO FRANK, SULLIVAN ROBERT, ERDMAN PAUL E, FUNG LEAH
Year of Publication 08.08.2019
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Year of Publication 08.08.2019
Patent
GSK-3 Spatial Regulation Has an Essential Role in Lenalidomide Activity and Represents a Biomarker of Clinical Response in CLL
Trudel, Suzanne, Scanga, Sam, Mastronardi, Fabrizio G, Wei, Ellen Nong, Mercurio, Frank, Lopez-Girona, Antonia, Gaidarova, Svetlana, Webb, David R., Chen, Christine, Stewart, Keith, Manoukian, Armen S
Published in Blood (16.11.2012)
Published in Blood (16.11.2012)
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단백질을 표적하는 화합물, 조성물, 방법, 및 그의 용도
CHAN KYLE W.H, SULLIVAN ROBERT, MERCURIO FRANK, ERDMAN PAUL E, FUNG LEAH
Year of Publication 15.01.2018
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Year of Publication 15.01.2018
Patent
Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
ARSURA, Marcello, PANTA, Ganesh R, SONENSHEIN, Gail E, BILYEU, Jennifer D, CAVIN, Lakita G, SOVAK, Mika A, OLIVER, Aundrea A, FACTOR, Valentina, HEUCHEL, Rainer, MERCURIO, Frank, THORGEIRSSON, Snorri S
Published in Oncogene (23.01.2003)
Published in Oncogene (23.01.2003)
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Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-κB in breast cancer
ROMIEU-MOUREZ, Raphaëlle, LANDESMAN-BOLLAG, Esther, SELDIN, David C, TRAISH, Abdulmaged M, MERCURIO, Frank, SONENSHEIN, Gail E
Published in Cancer research (Baltimore) (01.05.2001)
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Published in Cancer research (Baltimore) (01.05.2001)
Conference Proceeding
Regulation of α-fetoprotein by nuclear factor-κb protects hepatocytes from tumor necrosis factor-α cytotoxicity during fetal liver development and hepatic oncogenesis
CAVIN, Lakita G, VENKATRAMAN, Manickam, FACTOR, Valentina M, KAUR, Swayamjot, SCHROEDER, Insa, MERCURIO, Frank, BEG, Amer A, THORGEIRSSON, Snorri S, ARSURA, Marcello
Published in Cancer research (Chicago, Ill.) (01.10.2004)
Published in Cancer research (Chicago, Ill.) (01.10.2004)
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Identification of Novel Activities of Immunomodulatory Drugs: Cytoskeleton Reorganization through Modulation of Rho GTPases
Xu, Yibing, Li, JianWu, Ferguson, Greg, Mercurio, Frank, Khambatta, Gody, Morrison, Lisa, Lopez-Girona, Antonia, Corral, Laura G, Webb, David, Bennett, Brydon L., Xie, Weilin
Published in Blood (16.11.2008)
Published in Blood (16.11.2008)
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Targeting the p27Kip1 E3 Ubiquitin Ligase for the Treatment of Multiple Myeloma and Other Hematological Malignancies
Chen, Qing, Xie, Weilin, Kuhn, Deborah J., Voorhees, Peter M., Mendy, Derek, Lopez-Girona, Antonia, Plantevin, Veronique, Xu, Weiming, De Parseval, Laura, Corral, Laura G., Glezer, Emilia, Chan, Kyle, Mercurio, Frank, Orlowski, Robert Z.
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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FUSED THIOPHENE COMPOUNDS
CHOURASIA, APARAJITA HOSKOTE, MERCURIO, FRANK, SULLIVAN, ROBERT, FUNG, LEAH, CHAN, KYLE W.H, ERDMAN, PAUL E
Year of Publication 09.01.2024
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Year of Publication 09.01.2024
Patent