The host STING pathway at the interface of cancer and immunity
Corrales, Leticia, McWhirter, Sarah M, Dubensky, Jr, Thomas W, Gajewski, Thomas F
Published in The Journal of clinical investigation (01.07.2016)
Published in The Journal of clinical investigation (01.07.2016)
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Journal Article
Combination of the STING Agonist MIW815 (ADU-S100) and PD-1 Inhibitor Spartalizumab in Advanced/Metastatic Solid Tumors or Lymphomas: An Open-Label, Multicenter, Phase Ib Study
Meric-Bernstam, Funda, Sweis, Randy F, Kasper, Stefan, Hamid, Omid, Bhatia, Shailender, Dummer, Reinhard, Stradella, Agostina, Long, Georgina V, Spreafico, Anna, Shimizu, Toshio, Steeghs, Neeltje, Luke, Jason J, McWhirter, Sarah M, Müller, Thomas, Nair, Nitya, Lewis, Nancy, Chen, Xinhui, Bean, Andrew, Kattenhorn, Lisa, Pelletier, Marc, Sandhu, Shahneen
Published in Clinical cancer research (04.01.2023)
Published in Clinical cancer research (04.01.2023)
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Journal Article
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
Fu, Juan, Kanne, David B, Leong, Meredith, Glickman, Laura Hix, McWhirter, Sarah M, Lemmens, Edward, Mechette, Ken, Leong, Justin J, Lauer, Peter, Liu, Weiqun, Sivick, Kelsey E, Zeng, Qi, Soares, Kevin C, Zheng, Lei, Portnoy, Daniel A, Woodward, Joshua J, Pardoll, Drew M, Dubensky, Jr, Thomas W, Kim, Young
Published in Science translational medicine (15.04.2015)
Published in Science translational medicine (15.04.2015)
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A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
McWhirter, Sarah M, Barbalat, Roman, Monroe, Kathryn M, Fontana, Mary F, Hyodo, Mamoru, Joncker, Nathalie T, Ishii, Ken J, Akira, Shizuo, Colonna, Marco, Chen, Zhijian J, Fitzgerald, Katherine A, Hayakawa, Yoshihiro, Vance, Russell E
Published in The Journal of experimental medicine (31.08.2009)
Published in The Journal of experimental medicine (31.08.2009)
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Journal Article
MK5 activates Rag transcription via Foxo1 in developing B cells
Chow, Kwan T, Timblin, Greg A, McWhirter, Sarah M, Schlissel, Mark S
Published in The Journal of experimental medicine (29.07.2013)
Published in The Journal of experimental medicine (29.07.2013)
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Journal Article
Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas
Meric-Bernstam, Funda, Sweis, Randy F, Hodi, F Stephen, Messersmith, Wells A, Andtbacka, Robert H I, Ingham, Matthew, Lewis, Nancy, Chen, Xinhui, Pelletier, Marc, Chen, Xueying, Wu, Jincheng, McWhirter, Sarah M, Müller, Thomas, Nair, Nitya, Luke, Jason J
Published in Clinical cancer research (15.02.2022)
Published in Clinical cancer research (15.02.2022)
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Journal Article
Mucosal Vaccination with Cyclic Dinucleotide Adjuvants Induces Effective T Cell Homing and IL-17-Dependent Protection against Mycobacterium tuberculosis Infection
Jong, Robyn M, Van Dis, Erik, Berry, Samuel B, Nguyenla, Xammy, Baltodano, Alexander, Pastenkos, Gabrielle, Xu, Chenling, Fox, Douglas, Yosef, Nir, McWhirter, Sarah M, Stanley, Sarah A
Published in The Journal of immunology (1950) (15.01.2022)
Published in The Journal of immunology (1950) (15.01.2022)
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Journal Article
Correction: Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas
Meric-Bernstam, Funda, Sweis, Randy F, Hodi, F Stephen, Messersmith, Wells A, Andtbacka, Robert H I, Ingham, Matthew, Lewis, Nancy, Chen, Xinhui, Pelletier, Marc, Chen, Xueying, Wu, Jincheng, Dubensky, Thomas W, McWhirter, Sarah M, Müller, Thomas, Nair, Nitya, Luke, Jason J
Published in Clinical cancer research (13.06.2023)
Published in Clinical cancer research (13.06.2023)
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Journal Article
TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors
Francica, Brian J, Ghasemzadeh, Ali, Desbien, Anthony L, Theodros, Debebe, Sivick, Kelsey E, Reiner, Gabrielle L, Hix Glickman, Laura, Marciscano, Ariel E, Sharabi, Andrew B, Leong, Meredith L, McWhirter, Sarah M, Dubensky, Jr, Thomas W, Pardoll, Drew M, Drake, Charles G
Published in Cancer immunology research (01.04.2018)
Published in Cancer immunology research (01.04.2018)
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Journal Article
Abstract 1445: STING activation in the tumor microenvironment with a synthetic human STING-activating cyclic dinucleotide leads to potent anti-tumor immunity
Glickman, Laura Hix, Kanne, David B., Kasibhatla, Shailaja, Li, Jie, Pferdekamper, AnneMarie Culazzo, Gauthier, Kelsey Sivick, Deng, Weiwen, Desbien, Anthony L., Katibah, George E., Leong, Justin J., Sung, Leonard, Metchette, Ken, Ndubaku, Chudi, Zheng, Lianxing, Cho, Charles, Feng, Yan, McKenna, Jeffrey M., Tallarico, John A., Bender, Steven L., Dubensky, Thomas W., McWhirter, Sarah M.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract SY39-02: Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
Glickman, Laura Hix, Corrales, Leticia, Kanne, David B., Kasibhatla, Shailaja, Li, Jie, Pferdekamper, Anne Marie Culazzo, Gauthier, Kelsey Sivick, Katibah, George E., Leong, Justin J., Sung, Leonard, Metchette, Ken, Deng, Weiwen, Desbien, Anthony L., Ndubaku, Chudi, Zheng, Lianxing, Cho, Charles, Feng, Yan, McKenna, Jeffery M., Tallarico, John A., Bender, Steven L., McWhirter, Sarah M., Gajewski, Thomas F., Dubensky, Thomas W.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
인터페론 유전자의 자극인자"-의존적 신호전달을 활성화하는 조성물 및 방법
SUNG LEONARD, MCWHIRTER SARAH M, GLICKMAN LAURA HIX, KANNE DAVID, GAUTHIER KELSEY, LEONG JUSTIN, DUBENSKY JR. THOMAS W, KATIBAH GEORGE EDWIN
Year of Publication 27.11.2017
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Year of Publication 27.11.2017
Patent
"인터페론 유전자의 자극제"-의존성 신호전달을 활성화시키기 위한 조성물 및 방법
SUNG LEONARD, MCWHIRTER SARAH M, NDUBAKU CHUDI OBIOMA, GLICKMAN LAURA HIX, KANNE DAVID, MCKENNA JEFFREY, GAUTHIER KELSEY, LEONG JUSTIN, DUBENSKY THOMAS W. JR, CANHAM STEPHEN M, KATIBAH GEORGE EDWIN
Year of Publication 18.06.2018
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Year of Publication 18.06.2018
Patent
Mucosal vaccination with cyclic-di-nucleotide adjuvants induces effective T cell homing and IL-17-dependent protection against M. tuberculosis infection
Jong, Robyn M., Van Dis, Erik, Berry, Samuel B., Nguyenla, Xammy, Baltodano, Alexander, Pastenkos, Gabrielle, Xu, Chenling, Fox, Douglas, Yosef, Nir, McWhirter, Sarah M., Stanley, Sarah A.
Published in The Journal of immunology (1950) (29.12.2021)
Published in The Journal of immunology (1950) (29.12.2021)
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Journal Article
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, Katherine A., McWhirter, Sarah M., Faia, Kerrie L., Rowe, Daniel C., Latz, Eicke, Golenbock, Douglas T., Coyle, Anthony J., Liao, Sha-Mei, Maniatis, Tom
Published in Nature immunology (01.05.2003)
Published in Nature immunology (01.05.2003)
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Journal Article
Abstract 1202: Tumor cell intrinsic STING signaling demonstrates minimal contribution to the anti-tumor response elicited by the STING agonist ADU-S100 (MIW815)
Corrales, Leticia, Desbien, Antony L., Gauthier, Kelsey E. Sivick, Deng, Weiwen, Schroeder, Tamara, Reiner, Gabrielle L., Surh, Natalie, Francica, Brian, Metchette, Ken, Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Elsas, Andrea van, Leong, Meredith L., McWhirter, Sarah M.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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