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Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies
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Methionine Aminopeptidase 2 Inhibition Is an Effective Treatment Strategy for Neuroblastoma in Preclinical Models
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Published in Bioorganic & medicinal chemistry letters (01.06.2018)
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
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Methylpyrrole inhibitors of BET bromodomains
Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., McDaniel, Keith F.
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
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Imidazo[2,1- b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases
Fidanze, Steve D., Erickson, Scott A., Wang, Gary T., Mantei, Robert, Clark, Richard F., Sorensen, Bryan K., Bamaung, Nwe Y., Kovar, Peter, Johnson, Eric F., Swinger, Kerren K., Stewart, Kent D., Zhang, Qian, Tucker, Lora A., Pappano, William N., Wilsbacher, Julie L., Wang, Jieyi, Sheppard, George S., Bell, Randy L., Davidsen, Steven K., Hubbard, Robert D.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases
WANG, Gary T, MANTEI, Robert A, BOUSKA, Jennifer, JIEYI WANG, DAVIDSEN, Steven K, BELL, Randy L, SHEPPARD, George S, HUBBARD, Robert D, WILSBACHER, Julie L, QIAN ZHANG, TUCKER, Lora, XIAOMING HU, KOVAR, Peter, JOHNSON, Eric F, OSTERLING, Donald J
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
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Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2
JIEYI WANG, SHEPPARD, George S, FROST, David, TAPANG, Paul, ALBERT, Daniel H, MORGAN, Sherry J, MOROWITZ, Michael, SHUSTERMAN, Suzanne, MARIS, John M, LESNIEWSKI, Rick, HENKIN, Jack, PINGPING LOU, KAWAI, Megumi, BAMAUNG, Nwe, ERICKSON, Scott A, TUCKER-GARCIA, Lora, CHANG PARK, BOUSKA, Jennifer, WANG, Yi-Chun
Published in Cancer research (Chicago, Ill.) (15.11.2003)
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Published in Cancer research (Chicago, Ill.) (15.11.2003)
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Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties
Kawai, Megumi, BaMaung, Nwe Y., Fidanze, Steve D., Erickson, Scott A., Tedrow, Jason S., Sanders, William J., Vasudevan, Anil, Park, Chang, Hutchins, Charles, Comess, Kenneth M., Kalvin, Douglas, Wang, Jieyi, Zhang, Qian, Lou, Pingping, Tucker-Garcia, Lora, Bouska, Jennifer, Bell, Randy L., Lesniewski, Richard, Henkin, Jack, Sheppard, George S.
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases
HUBBARD, Robert D, BAMAUNG, Nwe Y, OSTERLING, Donald J, JOHNSON, Eric F, BOUSKA, Jennifer, JIEYI WANG, DAVIDSEN, Steven K, BELL, Randy L, SHEPPARD, George S, FIDANZE, Steve D, ERICKSON, Scott A, PALAZZO, Fabio, WILSBACHER, Julie L, QIAN ZHANG, TUCKER, Lora A, XIAOMING HU, KOVAR, Peter
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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Pyrazolo[3,4- d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR)
Hubbard, Robert D., Bamaung, Nwe Y., Palazzo, Fabio, Zhang, Qian, Kovar, Peter, Osterling, Donald J., Hu, Xiaoming, Wilsbacher, Julie L., Johnson, Eric F., Bouska, Jennifer, Wang, Jieyi, Bell, Randy L., Davidsen, Steven K., Sheppard, George S.
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2
SHEPPARD, George S, JIEYI WANG, PINGPING LOU, CHANG PARK, KIM, Ki H, HENKIN, Jack, LESNIEWSKI, Richard, KAWAI, Megumi, BAMAUNG, Nwe Y, CRAIG, Richard A, ERICKSON, Scott A, LYNCH, Linda, PATEL, Jyoti, FAN YANG, SEARLE, Xenia B
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
Wang, Gary T., Mantei, Robert A., Kawai, Megumi, Tedrow, Jason S., Barnes, David M., Wang, Jieyi, Zhang, Qian, Lou, Pingping, Garcia, Lora A., Bouska, Jennifer, Yates, Melinda, Park, Chang, Judge, Russell A., Lesniewski, Richard, Sheppard, George S., Bell, Randy L.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Lysyl 4-aminobenzoic acid derivatives as potent small molecule mimetics of plasminogen kringle 5
SHEPPARD, George S, KAWAI, Megumi, CRAIG, Richard A, DAVIDSON, Donald J, MAJEST, Sandra M, BELL, Randy L, HENKIN, Jack
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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TETRACYCLIC BROMODOMAIN INHIBITORS
JOHN PRATT, ROBERT A MANTEI, HASVOLD LISA A, GEORGE S SHEPPARD, JOHN H HOLMS, DAI YUJIA, JASMINA MARJANOVIC, LE WANG, LIU DACHUN, JUSTIN D DIETRICH, STEVEN D FIDANZE, MCDANIEL KEITH F, ANDREW BOGDAN
Year of Publication 31.01.2019
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Year of Publication 31.01.2019
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BROMODOMAIN INHIBITORS
WILLIAM J MCCLELLAN, ROBERT A MANTEI, JOHN H HOLMS, GEORGE S SHEPPARD, DAI YUJIA, CAROL K WADA, WARREN M KATI, LE WANG, LISA HASVOLD, LIU DACHUN, STEVEN D FIDANZE, MCDANIEL KEITH F, JOHN K PRATT
Year of Publication 08.11.2018
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Year of Publication 08.11.2018
Patent
BROMODOMAIN INHIBITORS
WILLIAM J MCCLELLAN, ROBERT A MANTEI, JOHN H HOLMS, GEORGE S SHEPPARD, DAI YUJIA, CAROL K WADA, WARREN M KATI, LE WANG, LISA HASVOLD, LIU DACHUN, STEVEN D FIDANZE, MCDANIEL KEITH F, JOHN K PRATT
Year of Publication 27.07.2017
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Year of Publication 27.07.2017
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Abstract 931: Discovery of ABBV-744, a first-in-class highly BDII-selective BET bromodomain inhibitor
Sheppard, George S., Wang, Le, Fidanze, Steven D., Hasvold, Lisa A., Liu, Dachun, Pratt, John K., Park, Chang H., Bui, Mai-Ha, Faivre, Emily J., Huang, Xiaoli, Lin, Xiaoyu, Wilcox, Denise M., Shen, Yu, Albert, Daniel H., Magoc, Terrance J., Rajaraman, Ganesh, Kati, Warren M., McDaniel, Keith F.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 4718: ABBV-075, a novel BET family bromodomain inhibitor, represents a promising therapeutic agent for a broad spectrum of cancer indications
Sarthy, Aparna, Li, Leiming, Albert, Daniel H., Lin, Xiaoyu, Scott, Warder, Faivre, Emily, Bui, Mai H., Huang, Xiaoli, Wilcox, Denise M., Magoc, Terry, Buchanan, Fritz G., Tapang, Paul, Sheppard, George S., Wang, Le, Fidanze, Steve D., Pratt, John, Liu, Dachun, Hasvold, Lisa, Hessler, Paul, Uziel, Tamar, Lam, Lloyd, Rajaraman, Ganesh, Fang, Guowei, Elmore, Steven W., Rosenberg, Saul H., McDaniel, Keith, Kati, Warren, Shen, Yu
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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