Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer
Brindani, Nicoletta, Vuong, Linh M., Acquistapace, Isabella Maria, La Serra, Maria Antonietta, Ortega, José Antonio, Veronesi, Marina, Bertozzi, Sine Mandrup, Summa, Maria, Girotto, Stefania, Bertorelli, Rosalia, Armirotti, Andrea, Ganesan, Anand K., De Vivo, Marco
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5
Brusa, Irene, Sondo, Elvira, Pesce, Emanuela, Tomati, Valeria, Gioia, Dario, Falchi, Federico, Balboni, Beatrice, Ortega Martínez, Jose Antonio, Veronesi, Marina, Romeo, Elisa, Margaroli, Natasha, Recanatini, Maurizio, Girotto, Stefania, Pedemonte, Nicoletta, Roberti, Marinella, Cavalli, Andrea
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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Binding Affinities of Oligonucleotides and PNAs Containing Phenoxazine and G-Clamp Cytosine Analogues Are Unusually Sequence-Dependent
Ortega, José-Antonio, Blas, José Ramón, Orozco, Modesto, Grandas, Anna, Pedroso, Enrique, Robles, Jordi
Published in Organic letters (25.10.2007)
Published in Organic letters (25.10.2007)
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Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders
Savardi, Annalisa, Borgogno, Marco, Narducci, Roberto, La Sala, Giuseppina, Ortega, Jose Antonio, Summa, Maria, Armirotti, Andrea, Bertorelli, Rosalia, Contestabile, Andrea, De Vivo, Marco, Cancedda, Laura
Published in Chem (06.08.2020)
Published in Chem (06.08.2020)
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Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells
Ortega, Jose Antonio, Arencibia, Jose M, La Sala, Giuseppina, Borgogno, Marco, Bauer, Inga, Bono, Luca, Braccia, Clarissa, Armirotti, Andrea, Girotto, Stefania, Ganesan, Anand, De Vivo, Marco
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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Journal Article
An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer
Myers, Samuel H., Poppi, Laura, Rinaldi, Francesco, Veronesi, Marina, Ciamarone, Andrea, Previtali, Viola, Bagnolini, Greta, Schipani, Fabrizio, Ortega Martínez, Jose Antonio, Girotto, Stefania, Di Stefano, Giuseppina, Farabegoli, Fulvia, Walsh, Naomi, De Franco, Francesca, Roberti, Marinella, Cavalli, Andrea
Published in European journal of medicinal chemistry (05.02.2024)
Published in European journal of medicinal chemistry (05.02.2024)
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Journal Article
Synthesis of Amino- and Guanidino-G-Clamp PNA Monomers
Ausín, Cristina, Ortega, José-Antonio, Robles, Jordi, Grandas, Anna, Pedroso, Enrique
Published in Organic letters (14.11.2002)
Published in Organic letters (14.11.2002)
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Journal Article
Synthetic Lethality through the Lens of Medicinal Chemistry
Myers, Samuel H, Ortega, Jose Antonio, Cavalli, Andrea
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Journal Article
Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action
Mühlethaler, Tobias, Milanos, Lampros, Ortega, Jose Antonio, Blum, Thorsten B., Gioia, Dario, Roy, Bibhas, Prota, Andrea E., Cavalli, Andrea, Steinmetz, Michel O.
Published in Angewandte Chemie International Edition (20.06.2022)
Published in Angewandte Chemie International Edition (20.06.2022)
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Journal Article
Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
de la Roche, Noelia Montel, Mühlethaler, Tobias, Di Martino, Rita Maria Concetta, Ortega, Jose Antonio, Gioia, Dario, Roy, Bibhas, Prota, Andrea E., Steinmetz, Michel O., Cavalli, Andrea
Published in European journal of medicinal chemistry (05.11.2022)
Published in European journal of medicinal chemistry (05.11.2022)
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Journal Article
Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib
Bagnolini, Greta, Milano, Domenico, Manerba, Marcella, Schipani, Fabrizio, Ortega, Jose Antonio, Gioia, Dario, Falchi, Federico, Balboni, Andrea, Farabegoli, Fulvia, De Franco, Francesca, Robertson, Janet, Pellicciari, Roberto, Pallavicini, Isabella, Peri, Sebastiano, Minucci, Saverio, Girotto, Stefania, Di Stefano, Giuseppina, Roberti, Marinella, Cavalli, Andrea
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
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Journal Article
Isolation and Characterization of Monomeric Human RAD51: A Novel Tool for Investigating Homologous Recombination in Cancer
Rinaldi, Francesco, Schipani, Fabrizio, Balboni, Beatrice, Catalano, Federico, Marotta, Roberto, Myers, Samuel H., Previtali, Viola, Veronesi, Marina, Scietti, Luigi, Cecatiello, Valentina, Pasqualato, Sebastiano, Ortega, Jose Antonio, Girotto, Stefania, Cavalli, Andrea
Published in Angewandte Chemie International Edition (18.12.2023)
Published in Angewandte Chemie International Edition (18.12.2023)
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Journal Article
Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
Ortega, Jose Antonio, Riccardi, Laura, Minniti, Elirosa, Borgogno, Marco, Arencibia, Jose M, Greco, Maria L, Minarini, Anna, Sissi, Claudia, De Vivo, Marco
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Journal Article
Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy
Brindani, Nicoletta, Vuong, Linh M., La Serra, Maria Antonietta, Salvador, Noel, Menichetti, Andrea, Acquistapace, Isabella Maria, Ortega, Jose Antonio, Veronesi, Marina, Bertozzi, Sine Mandrup, Summa, Maria, Girotto, Stefania, Bertorelli, Rosalia, Armirotti, Andrea, Ganesan, Anand K., De Vivo, Marco
Published in Journal of medicinal chemistry (27.06.2024)
Published in Journal of medicinal chemistry (27.06.2024)
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Journal Article
Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β
Ortega, Jose Antonio, Arencibia, Jose M, Minniti, Elirosa, Byl, Jo Ann W, Franco-Ulloa, Sebastian, Borgogno, Marco, Genna, Vito, Summa, Maria, Bertozzi, Sine Mandrup, Bertorelli, Rosalia, Armirotti, Andrea, Minarini, Anna, Sissi, Claudia, Osheroff, Neil, De Vivo, Marco
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Journal Article
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N‑Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration
Di Fruscia, Paolo, Carbone, Anna, Bottegoni, Giovanni, Berti, Francesco, Giacomina, Francesca, Ponzano, Stefano, Pagliuca, Chiara, Fiasella, Annalisa, Pizzirani, Daniela, Ortega, Jose Antonio, Nuzzi, Andrea, Tarozzo, Glauco, Mengatto, Luisa, Giampà, Roberta, Penna, Ilaria, Russo, Debora, Romeo, Elisa, Summa, Maria, Bertorelli, Rosalia, Armirotti, Andrea, Bertozzi, Sine Mandrup, Reggiani, Angelo, Bandiera, Tiziano, Bertozzi, Fabio
Published in Journal of medicinal chemistry (23.09.2021)
Published in Journal of medicinal chemistry (23.09.2021)
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Journal Article
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure–activity relationship (SAR) studies
Nuzzi, Andrea, Fiasella, Annalisa, Ortega, Jose Antonio, Pagliuca, Chiara, Ponzano, Stefano, Pizzirani, Daniela, Bertozzi, Sine Mandrup, Ottonello, Giuliana, Tarozzo, Glauco, Reggiani, Angelo, Bandiera, Tiziano, Bertozzi, Fabio, Piomelli, Daniele
Published in European journal of medicinal chemistry (23.03.2016)
Published in European journal of medicinal chemistry (23.03.2016)
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Journal Article
Isolation and Characterization of Monomeric Human RAD51: A Novel Tool for Investigating Homologous Recombination in Cancer
Rinaldi, Francesco, Schipani, Fabrizio, Balboni, Beatrice, Catalano, Federico, Marotta, Roberto, Myers, Samuel H., Previtali, Viola, Veronesi, Marina, Scietti, Luigi, Cecatiello, Valentina, Pasqualato, Sebastiano, Ortega, Jose Antonio, Girotto, Stefania, Cavalli, Andrea
Published in Angewandte Chemie (18.12.2023)
Published in Angewandte Chemie (18.12.2023)
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Journal Article
Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action
Mühlethaler, Tobias, Milanos, Lampros, Ortega, Jose Antonio, Blum, Thorsten B., Gioia, Dario, Roy, Bibhas, Prota, Andrea E., Cavalli, Andrea, Steinmetz, Michel O.
Published in Angewandte Chemie (20.06.2022)
Published in Angewandte Chemie (20.06.2022)
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Journal Article
An 19 F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer
Myers, Samuel H, Poppi, Laura, Rinaldi, Francesco, Veronesi, Marina, Ciamarone, Andrea, Previtali, Viola, Bagnolini, Greta, Schipani, Fabrizio, Ortega Martínez, Jose Antonio, Girotto, Stefania, Di Stefano, Giuseppina, Farabegoli, Fulvia, Walsh, Naomi, De Franco, Francesca, Roberti, Marinella, Cavalli, Andrea
Published in European journal of medicinal chemistry (05.02.2024)
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Published in European journal of medicinal chemistry (05.02.2024)
Journal Article