Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog
Heikkinen, Aki T., Friedlein, Arno, Lamerz, Jens, Jakob, Peter, Cutler, Paul, Fowler, Stephen, Williamson, Tara, Tolando, Roberto, Lave, Thierry, Parrott, Neil
Published in Pharmaceutical research (01.07.2012)
Published in Pharmaceutical research (01.07.2012)
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Physiologically Based Pharmacokinetic (PBPK) Modeling of Disposition of Epiroprim in Humans
Luttringer, Olivier, Theil, Frank‐Peter, Poulin, Patrick, Schmitt‐Hoffmann, Anne H., Guentert, Theodor Walter, Lavé, Thierry
Published in Journal of pharmaceutical sciences (01.10.2003)
Published in Journal of pharmaceutical sciences (01.10.2003)
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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance
Ring, Barbara J., Chien, Jenny Y., Adkison, Kimberly K., Jones, Hannah M., Rowland, Malcolm, Jones, Rhys Do, Yates, James W.T., Ku, M. Sherry, Gibson, Christopher R., He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Poulin, Patrick
Published in Journal of pharmaceutical sciences (01.10.2011)
Published in Journal of pharmaceutical sciences (01.10.2011)
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PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach
Poulin, Patrick, Jones, Rhys D.O., Jones, Hannah M., Gibson, Christopher R., Rowland, Malcolm, Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., Ku, M. Sherry, He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Yates, James W.T.
Published in Journal of pharmaceutical sciences (01.10.2011)
Published in Journal of pharmaceutical sciences (01.10.2011)
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Translational PK/PD modeling for cardiovascular safety assessment of drug candidates: Methods and examples in drug development
Caruso, Antonello, Frances, Nicolas, Meille, Christophe, Greiter-Wilke, Andrea, Hillebrecht, Alexander, Lavé, Thierry
Published in Journal of pharmacological and toxicological methods (01.07.2014)
Published in Journal of pharmacological and toxicological methods (01.07.2014)
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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: Comparative assessment of prediction methods of human volume of distribution
Jones, Rhys Do, Jones, Hannah M., Rowland, Malcolm, Gibson, Christopher R., Yates, James W.T., Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., Ku, M. Sherry, He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Poulin, Patrick
Published in Journal of pharmaceutical sciences (01.10.2011)
Published in Journal of pharmaceutical sciences (01.10.2011)
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PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation
Caruso, Antonello, Alvarez-Sánchez, Ruben, Hillebrecht, Alexander, Poirier, Agnès, Schuler, Franz, Lavé, Thierry, Funk, Christoph, Belli, Sara
Published in Biochemical pharmacology (01.06.2013)
Published in Biochemical pharmacology (01.06.2013)
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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: Prediction of plasma concentration–time profiles in human from in vivo preclinical data by using the Wajima approach
Vuppugalla, Ragini, Marathe, Punit, He, Handan, Jones, Rhys D.O., Yates, James W.T., Jones, Hannah M., Gibson, Christopher R., Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., Ku, M. Sherry, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Poulin, Patrick
Published in Journal of pharmaceutical sciences (01.10.2011)
Published in Journal of pharmaceutical sciences (01.10.2011)
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PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, Part 1: Goals, Properties of the Phrma Dataset, and Comparison with Literature Datasets
Poulin, Patrick, Jones, Hannah M., Jones, Rhys Do, Yates, James W.T., Gibson, Christopher R., Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Sherry Ku, M.
Published in Journal of pharmaceutical sciences (01.10.2011)
Published in Journal of pharmaceutical sciences (01.10.2011)
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Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs
Kristoffersson, Anders N., David-Pierson, Pascale, Parrott, Neil J., Kuhlmann, Olaf, Lave, Thierry, Friberg, Lena E., Nielsen, Elisabet I.
Published in Pharmaceutical research (01.05.2016)
Published in Pharmaceutical research (01.05.2016)
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Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes
Luttringer, Olivier, Theil, Frank-Peter, Lavé, Thierry, Wernli-Kuratli, Karin, Guentert, Theodor W, de Saizieu, Antoine
Published in Biochemical pharmacology (01.12.2002)
Published in Biochemical pharmacology (01.12.2002)
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A pharmacokinetic–pharmacodynamic model for cardiovascular safety assessment of R1551
Fleury, Angèle, Lavé, Thierry, Jonsson, Fredrik, Schmitt, Monique, Hirkaler, Gerard, Polonchuk, Liudmila, Breidenbach, Alexander
Published in Journal of pharmacological and toxicological methods (01.01.2011)
Published in Journal of pharmacological and toxicological methods (01.01.2011)
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Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity
Zbinden, Katrin Groebke, Banner, David W., Hilpert, Kurt, Himber, Jacques, Lavé, Thierry, Riederer, Markus A., Stahl, Martin, Tschopp, Thomas B., Obst-Sander, Ulrike
Published in Bioorganic & medicinal chemistry (01.08.2006)
Published in Bioorganic & medicinal chemistry (01.08.2006)
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Comparison and assessment of CaV1.2 kinetics described by different in silico cellular cardiac electrophysiology models
Wang, Ken, Cooper, Jonathan, Mirams, Gary, Gavaghan, David, Davies, Mark, Schuler, Franz, Lave, Thierry, Singer, Thomas, Polonchuk, Liudmila
Published in Journal of pharmacological and toxicological methods (01.09.2018)
Published in Journal of pharmacological and toxicological methods (01.09.2018)
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Journal Article
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors
Zbinden, Katrin Groebke, Obst-Sander, Ulrike, Hilpert, Kurt, Kühne, Holger, Banner, David W., Böhm, Hans-Joachim, Stahl, Martin, Ackermann, Jean, Alig, Leo, Weber, Lutz, Wessel, Hans Peter, Riederer, Markus A., Tschopp, Thomas B., Lavé, Thierry
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
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What are the challenges and opportunities ahead of any regulatory requirements for in silico cardiac pro-arrhythmia prediction?
Davies, Mark, Wang, Ken, Caruso, Antonello, Mirams, Gary, Noble, Denis, Walz, Antje, Lave, Thierry, Schuler, Franz, Singer, Thomas, Polonchuk, Liudmila
Published in Journal of pharmacological and toxicological methods (01.09.2016)
Published in Journal of pharmacological and toxicological methods (01.09.2016)
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Tailoring in silico model to electrophysiology of individual iPSC-derived cardiomyocyte lines: One-size fits all?
Lei, Chon Lok, Wang, Ken, Gissinger, Evgenia, Flint, Nicholas, Mamta, Chabria, Badi, Laura, Hoflack, Jean-Christophe, Schuler, Franz, Lave, Thierry, Singer, Thomas, Clerx, Michael, Gavaghan, David, Mirams, Gary, Polonchuk, Liudmila
Published in Journal of pharmacological and toxicological methods (01.09.2018)
Published in Journal of pharmacological and toxicological methods (01.09.2018)
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