Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain
Stachel, Shawn J, Sanders, John M, Henze, Darrell A, Rudd, Mike T, Su, Hua-Poo, Li, Yiwei, Nanda, Kausik K, Egbertson, Melissa S, Manley, Peter J, Jones, Kristen L. G, Brnardic, Edward J, Green, Ahren, Grobler, Jay A, Hanney, Barbara, Leitl, Michael, Lai, Ming-Tain, Munshi, Vandna, Murphy, Dennis, Rickert, Keith, Riley, Daniel, Krasowska-Zoladek, Alicja, Daley, Christopher, Zuck, Paul, Kane, Stephanie A, Bilodeau, Mark T
Published in Journal of medicinal chemistry (10.07.2014)
Published in Journal of medicinal chemistry (10.07.2014)
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Journal Article
Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV
Schreier, John D., Embrey, Mark W., Raheem, Izzat T., Barbe, Guillaume, Campeau, Louis-Charles, Dubost, David, McCabe Dunn, Jamie, Grobler, Jay, Hartingh, Timothy J., Hazuda, Daria J., Klein, Daniel, Miller, Michael D., Moore, Keith P., Nguyen, Natalie, Pajkovic, Natasa, Powell, David A., Rada, Vanessa, Sanders, John M., Sisko, John, Steele, Thomas G., Wai, John, Walji, Abbas, Xu, Min, Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (01.05.2017)
Published in Bioorganic & medicinal chemistry letters (01.05.2017)
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Journal Article
3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts
Brnardic, Edward J., Fraley, Mark E., Garbaccio, Robert M., Layton, Mark E., Sanders, John M., Culberson, Chris, Jacobson, Marlene A., Magliaro, Brian C., Hutson, Pete H., O’Brien, Julie A., Huszar, Sarah L., Uslaner, Jason M., Fillgrove, Kerry L., Tang, Cuyue, Kuo, Yuhsin, Sur, Sylvie M., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Journal Article
Crystallographic Structures of Two Bisphosphonate:1-Deoxyxylulose-5-Phosphate Reductoisomerase Complexes
Yajima, Shunsuke, Hara, Kodai, Sanders, John M, Yin, Fenglin, Ohsawa, Kanju, Wiesner, Jochen, Jomaa, Hassan, Oldfield, Eric
Published in Journal of the American Chemical Society (08.09.2004)
Published in Journal of the American Chemical Society (08.09.2004)
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Journal Article
Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity
Scott, Jack D, DeMong, Duane E, Greshock, Thomas J, Basu, Kallol, Dai, Xing, Harris, Joel, Hruza, Alan, Li, Sarah W, Lin, Sue-Ing, Liu, Hong, Macala, Megan K, Hu, Zhiyong, Mei, Hong, Zhang, Honglu, Walsh, Paul, Poirier, Marc, Shi, Zhi-Cai, Xiao, Li, Agnihotri, Gautam, Baptista, Marco A. S, Columbus, John, Fell, Matthew J, Hyde, Lynn A, Kuvelkar, Reshma, Lin, Yinghui, Mirescu, Christian, Morrow, John A, Yin, Zhizhang, Zhang, Xiaoping, Zhou, Xiaoping, Chang, Ronald K, Embrey, Mark W, Sanders, John M, Tiscia, Heather E, Drolet, Robert E, Kern, Jonathan T, Sur, Sylvie M, Renger, John J, Bilodeau, Mark T, Kennedy, Matthew E, Parker, Eric M, Stamford, Andrew W, Nargund, Ravi, McCauley, John A, Miller, Michael W
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates and Diphosphates: A Potential Route to New Bone Antiresorption and Antiparasitic Agents
Szabo, Christina M, Matsumura, Yoshihiro, Fukura, Sayaka, Martin, Michael B, Sanders, John M, Sengupta, Suraj, Cieslak, John A, Loftus, Timothy C, Lea, Christopher R, Lee, Hyung-Jae, Koohang, Ali, Coates, Robert M, Sagami, Hiroshi, Oldfield, Eric
Published in Journal of medicinal chemistry (23.05.2002)
Published in Journal of medicinal chemistry (23.05.2002)
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Journal Article
Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery
Yan, Xin Cindy, Sanders, John M, Gao, Ying-Duo, Tudor, Matthew, Haidle, Andrew M, Klein, Daniel J, Converso, Antonella, Lesburg, Charles A, Zang, Yi, Wood, Harold B
Published in Journal of chemical information and modeling (28.09.2020)
Published in Journal of chemical information and modeling (28.09.2020)
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Journal Article
Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles
Sanders, John M, Beshore, Douglas C, Culberson, J Christopher, Fells, James I, Imbriglio, Jason E, Gunaydin, Hakan, Haidle, Andrew M, Labroli, Marc, Mattioni, Brian E, Sciammetta, Nunzio, Shipe, William D, Sheridan, Robert P, Suen, Linda M, Verras, Andreas, Walji, Abbas, Joshi, Elizabeth M, Bueters, Tjerk
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Journal Article
Discovery of 2‑Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV‑1 Integrase Strand Transfer Inhibitors
Raheem, Izzat T, Walji, Abbas M, Klein, Daniel, Sanders, John M, Powell, David A, Abeywickrema, Pravien, Barbe, Guillaume, Bennet, Amrith, Clas, Sophie−Dorothee, Dubost, David, Embrey, Mark, Grobler, Jay, Hafey, Michael J, Hartingh, Timothy J, Hazuda, Daria J, Miller, Michael D, Moore, Keith P, Pajkovic, Natasa, Patel, Sangita, Rada, Vanessa, Rearden, Paul, Schreier, John D, Sisko, John, Steele, Thomas G, Truchon, Jean-François, Wai, John, Xu, Min, Coleman, Paul J
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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Journal Article
Amiodarone Has Intrinsic Anti-Trypanosoma cruzi Activity and Acts Synergistically with Posaconazole
BENAIM, Gustavo, SANDERS, John M., GARCIA-MARCHáN, Yael, COLINA, Claudia, LIRA, Renee, CALDERA, Aura R., PAYARES, Gilberto, SANOJA, Cristina, BURGOS, Juan Miguel, LEON-ROSSELL, Annette, CONCEPCION, Juan Luis, SCHIJMAN, Alejandro G., LEVIN, Mariano, OLDFIELD, Eric, URBINA, Julio A.
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Journal Article
Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors
Greshock, Thomas J., Sanders, John M., Drolet, Robert E., Rajapakse, Hemaka A., Chang, Ronald K., Kim, Boyoung, Rada, Vanessa L., Tiscia, Heather E., Su, Hua, Lai, Ming-Tain, Sur, Sylvie M., Sanchez, Rosa I., Bilodeau, Mark T., Renger, John J., Kern, Jonathan T., McCauley, John A.
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
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Journal Article
Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles: Miniperspective
Sanders, John M, Beshore, Douglas C, Culberson, J. Christopher, Fells, James I, Imbriglio, Jason E, Gunaydin, Hakan, Haidle, Andrew M, Labroli, Marc, Mattioni, Brian E, Sciammetta, Nunzio, Shipe, William D, Sheridan, Robert P, Suen, Linda M, Verras, Andreas, Walji, Abbas, Joshi, Elizabeth M, Bueters, Tjerk
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Journal Article
Solid-State NMR, Crystallographic, and Computational Investigation of Bisphosphonates and Farnesyl Diphosphate Synthase−Bisphosphonate Complexes
Mao, Junhong, Mukherjee, Sujoy, Zhang, Yong, Cao, Rong, Sanders, John M, Song, Yongcheng, Zhang, Yonghui, Meints, Gary A, Gao, Yi Gui, Mukkamala, Dushyant, Hudock, Michael P, Oldfield, Eric
Published in Journal of the American Chemical Society (15.11.2006)
Published in Journal of the American Chemical Society (15.11.2006)
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Journal Article
Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors
Zhao, Zhijian, Harrison, Scott T., Schubert, Jeffrey W., Sanders, John M., Polsky-Fisher, Stacey, Zhang, Nanyan Rena, McLoughlin, Debra, Gibson, Christopher R., Robinson, Ronald G., Sachs, Nancy A., Kandebo, Monika, Yao, Lihang, Smith, Sean M., Hutson, Pete H., Wolkenberg, Scott E., Barrow, James C.
Published in Bioorganic & medicinal chemistry letters (15.06.2016)
Published in Bioorganic & medicinal chemistry letters (15.06.2016)
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Journal Article
Quantitative Structure−Activity Relationships for γδ T Cell Activation by Bisphosphonates
Sanders, John M, Ghosh, Subhash, Chan, Julian M. W, Meints, Gary, Wang, Hong, Raker, Amy M, Song, Yongcheng, Colantino, Alison, Burzynska, Agnieszka, Kafarski, Pawel, Morita, Craig T, Oldfield, Eric
Published in Journal of medicinal chemistry (15.01.2004)
Published in Journal of medicinal chemistry (15.01.2004)
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Journal Article
Attenuation of scratch‐induced reactive astrogliosis by novel EphA4 kinase inhibitors
Parmentier‐Batteur, Sophie, Finger, Eleftheria N., Krishnan, Raghu, Rajapakse, Hemaka A., Sanders, John M., Kandpal, Geeta, Zhu, Hong, Moore, Keith P., Regan, Christopher P., Sharma, Sujata, Hess, J. Fred, Williams, Theresa M., Reynolds, Ian J., Vacca, Joseph P., Mark, Robert J., Nantermet, Philippe G.
Published in Journal of neurochemistry (01.09.2011)
Published in Journal of neurochemistry (01.09.2011)
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Journal Article
Correction to Discovery of 2‑Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV‑1 Integrase Strand Transfer Inhibitors
Raheem, Izzat T, Walji, Abbas M, Klein, Daniel, Sanders, John M, Powell, David A, Abeywickrema, Pravien, Barbe, Guillaume, Bennet, Amrith, Childers, Karla, Christensen, Melodie, Clas, Sophie−Dorothee, Dubost, David, Embrey, Mark, Grobler, Jay, Hafey, Michael J, Hartingh, Timothy J, Hazuda, Daria J, Kuethe, Jeffrey T, McCabe Dunn, Jamie, Miller, Michael D, Moore, Keith P, Nolting, Andrew, Pajkovic, Natasa, Patel, Sangita, Peng, Zuihui, Rada, Vanessa, Rearden, Paul, Schreier, John D, Sisko, John, Steele, Thomas G, Truchon, Jean-François, Wai, John, Xu, Min, Coleman, Paul J
Published in Journal of medicinal chemistry (14.01.2016)
Published in Journal of medicinal chemistry (14.01.2016)
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Journal Article
3-D QSAR Investigations of the Inhibition of Leishmania major Farnesyl Pyrophosphate Synthase by Bisphosphonates
SANDERS, John M., GóMEZ, Aurora Ortiz, MAO, Junhong, MEINTS, Gary A., VAN BRUSSEL, Erin M., BURZYNSKA, Agnieszka, KAFARSKI, Pawel, GONZáLEZ-PACANOWSKA, Dolores, OLDFIELD, Eric
Published in Journal of medicinal chemistry (20.11.2003)
Published in Journal of medicinal chemistry (20.11.2003)
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Journal Article
Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies
Montalvetti, Andrea, Fernandez, Alexis, Sanders, John M, Ghosh, Subhash, Van Brussel, Erin, Oldfield, Eric, Docampo, Roberto
Published in The Journal of biological chemistry (09.05.2003)
Published in The Journal of biological chemistry (09.05.2003)
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Journal Article