Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88
Dzierba, Carolyn D., Bi, Yingzhi, Dasgupta, Bireshwar, Hartz, Richard A., Ahuja, Vijay, Cianchetta, Giovanni, Kumi, Godwin, Dong, Li, Aleem, Saadat, Fink, Cynthia, Garcia, Yudith, Green, Michael, Han, Jianxin, Kwon, Soojin, Qiao, Ying, Wang, Jiancheng, Zhang, Yulian, Liu, Ying, Zipp, Greg, Liang, Zhi, Burford, Neil, Ferrante, Meredith, Bertekap, Robert, Lewis, Martin, Cacace, Angela, Grace, James, Wilson, Alan, Nouraldeen, Amr, Westphal, Ryan, Kimball, David, Carson, Kenneth, Bronson, Joanne J., Macor, John E.
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
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The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders
Bi, Yingzhi, Dzierba, Carolyn D., Fink, Cynthia, Garcia, Yudith, Green, Michael, Han, Jianxin, Kwon, Soojin, Kumi, Godwin, Liang, Zhi, Liu, Ying, Qiao, Ying, Zhang, Yulian, Zipp, Greg, Burford, Neil, Ferrante, Meredith, Bertekap, Robert, Lewis, Martin, Cacace, Angela, Westphal, Ryan S., Kimball, David, Bronson, Joanne J., Macor, John E.
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
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Journal Article
Discovery of a new series of PI3K-6 inhibitors from Virtual Screening
Fradera, Xavier, Deng, Qiaolin, Achab, Abdelganhi, Garcia, Yudith, Kattar, Solomon D., McGowan, Meredeth A., Methot, Joey L., Wilson, Kevin, Zhou, Hua, Shaffer, Lynsey, Goldenblatt, Peter, Tong, Vincent, Augustin, Martin A., Altman, Michael D., Lesburg, Charles A., Shah, Sanjiv, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
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Journal Article
Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow
Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
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Journal Article
Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators
Methot, Joey L, Zhou, Hua, McGowan, Meredeth A, Anthony, Neville John, Christopher, Matthew, Garcia, Yudith, Achab, Abdelghani, Lipford, Kathryn, Trotter, Benjamin Wesley, Altman, Michael D, Fradera, Xavier, Lesburg, Charles A, Li, Chaomin, Alves, Stephen, Chappell, Craig P, Jain, Renu, Mangado, Ruban, Pinheiro, Elaine, Williams, Sybill M. G, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vincent, McLeod, Robbie L, Lee, Hyun-Hee, Yu, Hongshi, Shah, Sanjiv, Katz, Jason D
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
Discovery of a new series of PI3K-δ inhibitors from Virtual Screening
Fradera, Xavier, Deng, Qiaolin, Achab, Abdelganhi, Garcia, Yudith, Kattar, Solomon D., McGowan, Meredeth A., Methot, Joey L., Wilson, Kevin, Zhou, Hua, Shaffer, Lynsey, Goldenblatt, Peter, Tong, Vincent, Augustin, Martin A, Altman, Michael D., Lesburg, Charles A., Shah, Sanjiv, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
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Journal Article
Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability
Methot, Joey L, Zhou, Hua, Kattar, Sam D, McGowan, Meredeth A, Wilson, Kevin, Garcia, Yudith, Deng, Yongi, Altman, Michael, Fradera, Xavier, Lesburg, Charles, Fischmann, Thierry, Li, Chaomin, Alves, Steve, Shah, Sanjiv, Fernandez, Rafael, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vince, McLeod, Robbie L, Yu, Hongshi, Bass, Alan, Kemper, Ray, Gatto, Nicholas T, LaFranco-Scheuch, Lisa, Trotter, Benjamin Wesley, Guzi, Timothy, Katz, Jason D
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
Corrigendum to “Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow” [Bioorg. Med. Chem. Lett. 29 (2019) 2575–2580]
Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
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Journal Article
Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors
Simov, Vladimir, Deshmukh, Sujal V., Dinsmore, Christopher J., Elwood, Fiona, Fernandez, Rafael B., Garcia, Yudith, Gibeau, Craig, Gunaydin, Hakan, Jung, Joon, Katz, Jason D., Kraybill, Brian, Lapointe, Blair, Patel, Sangita B., Siu, Tony, Su, Hua, Young, Jonathan R.
Published in Bioorganic & medicinal chemistry letters (01.04.2016)
Published in Bioorganic & medicinal chemistry letters (01.04.2016)
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Purine derivatives as potent γ-secretase modulators
Rivkin, Alexey, Ahearn, Sean P., Chichetti, Stephanie M., Hamblett, Christopher L., Garcia, Yudith, Martinez, Michelle, Hubbs, Jed L., Reutershan, Michael H., Daniels, Matthew H., Siliphaivanh, Phieng, Otte, Karin M., Li, Chaomin, Rosenau, Andrew, Surdi, Laura M., Jung, Joon, Hughes, Bethany L., Crispino, Jamie L., Nikov, George N., Middleton, Richard E., Moxham, Christopher M., Szewczak, Alexander A., Shah, Sanjiv, Moy, Lily Y., Kenific, Candia M., Tanga, Flobert, Cruz, Jonathan C., Andrade, Paula, Angagaw, Minilik H., Shomer, Nirah H., Miller, Thomas, Munoz, Benito, Shearman, Mark S.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
Purine derivatives as potent g-secretase modulators
Rivkin, Alexey, Ahearn, Sean P, Chichetti, Stephanie M, Hamblett, Christopher L, Garcia, Yudith, Martinez, Michelle, Hubbs, Jed L, Reutershan, Michael H, Daniels, Matthew H, Siliphaivanh, Phieng, Otte, Karin M, Li, Chaomin, Rosenau, Andrew, Surdi, Laura M, Jung, Joon, Hughes, Bethany L, Crispino, Jamie L, Nikov, George N, Middleton, Richard E, Moxham, Christopher M, Szewczak, Alexander A, Shah, Sanjiv, Moy, Lily Y, Kenific, Candia M, Tanga, Flobert, Cruz, Jonathan C, Andrade, Paula, Angagaw, Minilik H, Shomer, Nirah H, Miller, Thomas, Munoz, Benito, Shearman, Mark S
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA
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Year of Publication 22.07.2015
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PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA
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PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA
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Year of Publication 25.12.2019
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Year of Publication 25.12.2019
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PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA
MCGOWAN, Meredeth, DENG, Yongqi, ACHAB, Abdelghani Abe, FONG, Kin Chiu, MU, Changwei, LENG, Xiansheng, ZHANG, Rong, KATZ, Jason D, METHOT, Joey L, CHRISTOPHER, Matthew P, ANTHONY, Neville John, ZHANG, Sixing, ZHOU, Hua, KATTAR, Solomon, FRADERA LLINAS, Francesc Xavier, GARCIA, Yudith, ALTMAN, Michael D, GUZI, Timothy
Year of Publication 29.08.2018
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Year of Publication 29.08.2018
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Purine inhibitors of human phosphatidylinositol 3-kinase delta
Yang Liping, Anthony Neville John, Ye Baijun, Altman Michael D, Shi Feng, Zhou Hua, Fradera Llinas Francesc Xavier, Kattar Solomon, Zhang Rong, McGowan Meredeth, Katz Jason D, Deng Yongqi, Christopher Matthew P, Leng Xiansheng, Achab Abdelghani Abe, Methot Joey L, Wang Xiaona, Zhang Sixing, Mu Changwei, Fong Kin Chiu, Garcia Yudith, Zhao Xiaoli
Year of Publication 10.04.2018
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Year of Publication 10.04.2018
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Purine inhibitors of human phosphatidylinositol 3-kinase delta
Anthony Neville John, Altman Michael D, Zhou Hua, Fradera Llinas Francesc Xavier, Kattar Solomon, Zhang Rong, McGowan Meredeth, Katz Jason D, Deng Yongqi, Christopher Matthew P, Leng Xiansheng, Achab Abdelghani Abe, Methot Joey L, Zhang Sixing, Fong Kin Chiu, Mu Changwei, Garcia Yudith, Guzi Timothy
Year of Publication 15.08.2017
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Year of Publication 15.08.2017
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Purine inhibitors of human phosphatidylinositol 3-kinase delta
Leng, Xiansheng, Methot, Joey L, Anthony, Neville John, Zhou, Hua, Achab, Abdelghani Abe, Altman, Michael D, Ye, Baijun, Zhao, Xiaoli, Christopher, Matthew P, Fradera Llinas, Francesc Xavier, Mu, Changwei, Yang, Liping, Zhang, Sixing, Deng, Yongqi, Katz, Jason D, Garcia, Yudith, Wang, Xiaona, Zhang, Rong, McGowan, Meredeth, Shi, Feng, Kattar, Solomon, Fong, Kin Chiu
Year of Publication 15.06.2017
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Year of Publication 15.06.2017
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Purine inhibitors of human phosphatidylinositol 3-kinase delta
Leng, Xiansheng, Methot, Joey L, Anthony, Neville John, Guzi, Timothy, Zhou, Hua, Achab, Abdelghani Abe, Altman, Michael D, Christopher, Matthew P, Fradera Llinas, Francesc Xavier, Mu, Changwei, Zhang, Sixing, Deng, Yongqi, Katz, Jason D, Garcia, Yudith, Zhang, Rong, McGowan, Meredeth, Kattar, Solomon, Fong, Kin Chiu
Year of Publication 27.04.2017
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Year of Publication 27.04.2017
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PURINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE
GARCIA, YUDITH, CHICHETTI, STEPHANIE, MARTINEZ, MICHELLE, AHEARN, SEAN, P, MUNOZ, BENITO, RIVKIN, ALEXEY, HAMBLETT, CHRISTOPHER, L
Year of Publication 09.05.2012
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Year of Publication 09.05.2012
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