Discovery of Novel Quaternary Ammonium Derivatives of (3R)-Quinuclidinol Esters as Potent and Long-Acting Muscarinic Antagonists with Potential for Minimal Systemic Exposure after Inhaled Administration: Identification of (3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide (Aclidinium Bromide)
Prat, María, Fernández, Dolors, Buil, M. Antonia, Crespo, María I, Casals, Gaspar, Ferrer, Manuel, Tort, Laia, Castro, Jordi, Monleón, Juan M, Gavaldà, Amadeu, Miralpeix, Montserrat, Ramos, Israel, Doménech, Teresa, Vilella, Dolors, Antón, Francisca, Huerta, Josep M, Espinosa, Sonia, López, Manuel, Sentellas, Sonia, González, Marisa, Albertí, Joan, Segarra, Victor, Cárdenas, Alvaro, Beleta, Jorge, Ryder, Hamish
Published in Journal of medicinal chemistry (27.08.2009)
Published in Journal of medicinal chemistry (27.08.2009)
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Discovery of novel quaternary ammonium derivatives of (3 R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists
Prat, Maria, Buil, María Antonia, Fernández, Maria Dolors, Castro, Jordi, Monleón, Juan Manuel, Tort, Laia, Casals, Gaspar, Ferrer, Manuel, Huerta, Josep Maria, Espinosa, Sònia, López, Manuel, Segarra, Victor, Gavaldà, Amadeu, Miralpeix, Montserrat, Ramos, Israel, Vilella, Dolors, González, Marisa, Córdoba, Mònica, Cárdenas, Alvaro, Antón, Francisca, Beleta, Jorge, Ryder, Hamish
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Preclinical cardiotoxicity assessment: Can stem cell-derived cardiomyocytes contribute to the 3Rs?
Gryshkova, Vitalina, Lushbough, Isabel, Roquigny, Julia, Cardenas, Alvaro, Lowe, Martin, Delaunois, Annie, Valentin, Jean-Pierre
Published in Journal of pharmacological and toxicological methods (01.09.2021)
Published in Journal of pharmacological and toxicological methods (01.09.2021)
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Discovery and Characterization of 4‘-(2-Furyl)-N-pyridin-3-yl-4,5‘-bipyrimidin-2‘-amine (LAS38096), a Potent, Selective, and Efficacious A2B Adenosine Receptor Antagonist
Vidal, Bernat, Nueda, Arsenio, Esteve, Cristina, Domenech, Teresa, Benito, Sonia, Reinoso, Raquel F, Pont, Mercè, Calbet, Marta, López, Rosa, Cadavid, María Isabel, Loza, María Isabel, Cárdenas, Álvaro, Godessart, Núria, Beleta, Jorge, Warrellow, Graham, Ryder, Hamish
Published in Journal of medicinal chemistry (31.05.2007)
Published in Journal of medicinal chemistry (31.05.2007)
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Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362
Lowe, Martin A., Cardenas, Alvaro, Valentin, Jean-Pierre, Zhu, Zhaoning, Abendroth, Jan, Castro, Jose L., Class, Reiner, Delaunois, Annie, Fleurance, Renaud, Gerets, Helga, Gryshkova, Vitalina, King, Lloyd, Lorimer, Donald D., MacCoss, Malcolm, Rowley, Julian H., Rosseels, Marie-Luce, Royer, Leandro, Taylor, Richard D., Wong, Melanie, Zaccheo, Oliver, Chavan, Vishal P., Ghule, Gokul A., Tapkir, Bapusaheb K., Burrows, Jeremy N., Duffey, Maëlle, Rottmann, Matthias, Wittlin, Sergio, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Striepen, Josefine, Fairhurst, Kate J., Yeo, Tomas, Fidock, David A., Cowman, Alan F., Favuzza, Paola, Crespo-Fernandez, Benigno, Gamo, Francisco Javier, Goldberg, Daniel E., Soldati-Favre, Dominique, Laleu, Benoît, de Haro, Teresa
Published in Journal of medicinal chemistry (27.10.2022)
Published in Journal of medicinal chemistry (27.10.2022)
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Synthesis and Biological Evaluation of 2-Phenylpyran-4-ones: A New Class of Orally Active Cyclooxygenase-2 Inhibitors
Caturla, Francisco, Jiménez, Juan-Miguel, Godessart, Núria, Amat, Mercè, Cárdenas, Alvaro, Soca, Lídia, Beleta, Jordi, Ryder, Hamish, Crespo, María I
Published in Journal of medicinal chemistry (15.07.2004)
Published in Journal of medicinal chemistry (15.07.2004)
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New pyrrolopyrimidin-6-yl benzenesulfonamides : Potent A2B adenosine receptor antagonists
ESTEVE, Cristina, NUEDA, Arsenio, DIAZ, José Luis, BELETA, Jorge, CARDENAS, Alvaro, LOZOYA, Estrella, CADAVID, Maria Isabel, LOZA, Maria Isabel, RYDER, Hamish, VIDAV, Bernat
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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Synthesis and Structure−Activity Relationships of Novel Histamine H1 Antagonists: Indolylpiperidinyl Benzoic Acid Derivatives
Fonquerna, Silvia, Miralpeix, Montse, Pagès, Lluís, Puig, Carles, Cardús, Arantxa, Antón, Francisca, Cárdenas, Álvaro, Vilella, Dolors, Aparici, Mónica, Calaf, Elena, Prieto, José, Gras, Jordi, Huerta, Josep M, Warrellow, Graham, Beleta, Jorge, Ryder, Hamish
Published in Journal of medicinal chemistry (02.12.2004)
Published in Journal of medicinal chemistry (02.12.2004)
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Discovery and characterization of 4 '-(2-Furyl)-N-pyridin-3-yl-4,5 '-bipyrimidin-2 '-amine (LAS38096), a potent, selective, and efficacious A(2B) adenosine receptor antagonist
Vidal, Bernat, Nueda, Arsenio, Esteve, Cristina, Domenech, Teresa, Benito, Sonia, Reinoso, Raquel F., Pont, Merce, Calbet, Marta, Lopez, Rosa, Cadavid, Maria Isabel, Loza, Maria Isabel, Cardenas, Alvaro, Godessart, Nuria, Beleta, Jorge, Warrellow, Graham, Ryder, Hamish
Published in Journal of medicinal chemistry (31.05.2007)
Published in Journal of medicinal chemistry (31.05.2007)
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FLAME RETARDANT RIGID HIGH DENSITY POLYURETHANE FOAM
MUÑOZ, Omar Hernandez, REN, Dakai, OGUNNIYI, Adebola O, CARDENAS, Alvaro Ballesteros
Year of Publication 04.09.2024
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Year of Publication 04.09.2024
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FLAME RETARDANT RIGID HIGH DENSITY POLYURETHANE FOAM
Muñoz, Omar Hernandez, Cardenas, Alvaro Ballesteros, Ogunniyi, Adebola O, Ren, Dakai
Year of Publication 08.08.2024
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Year of Publication 08.08.2024
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New pyrrolopyrimidin-6-yl benzenesulfonamides: Potent A sub(2B) adenosine receptor antagonists
Esteve, Cristina, Nueda, Arsenio, Diaz, Jose Luis, Beleta, Jorge, Cardenas, Alvaro, Lozoya, Estrella, Cadavid, Maria Isabel, Loza, Maria Isabel, Ryder, Hamish, Vidal, Bernat
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Pyridinyl and pyrazinyl-(asa)indolsulfonamides
Ledecq, Marie, Pegurier, Cecile, Provins, Laurent, Boshta, Nader, El-Tayeb, Ali, Rashed, Mahmoud, Mueller, Christa E, Cardenas, Alvaro, Hockemeyer, Joerg
Year of Publication 26.03.2024
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Year of Publication 26.03.2024
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FLAME RETARDANT RIGID HIGH DENSITY POLYURETHANE FOAM
MUÑOZ, Omar Hernandez, REN, Dakai, OGUNNIYI, Adebola O, CARDENAS, Alvaro Ballesteros
Year of Publication 04.05.2023
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Year of Publication 04.05.2023
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Pyridinyl and pyrazinyl-(aza)indolsulfonamides
EL-TAYEB, Ali, PEGURIER, Cécile, MUELLER, Christa E, LEDECQ, Marie, BOSHTA, Nader, RASHED, Mahmoud, PROVINS, Laurent, CARDENAS, Alvaro, HOCKEMEYER, Joerg
Year of Publication 11.07.2024
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Year of Publication 11.07.2024
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PYRIDINYL-(AZA)INDOLSULFONAMIDES
EL-TAYEB, Ali, PEGURIER, Cécile, MUELLER, Christa E, LEDECQ, Marie, BOSHTA, Nader, RASHED, Mahmoud, PROVINS, Laurent, CARDENAS, Alvaro, HOCKEMEYER, Joerg
Year of Publication 01.02.2024
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Year of Publication 01.02.2024
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PYRIDINYL-(AZA)INDOLSULFONAMIDES
EL-TAYEB, Ali, PEGURIER, Cécile, MUELLER, Christa E, LEDECQ, Marie, BOSHTA, Nader, RASHED, Mahmoud, PROVINS, Laurent, CARDENAS, Alvaro, HOCKEMEYER, Joerg
Year of Publication 29.11.2023
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Year of Publication 29.11.2023
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PYRIDINYL AND PYRAZINYL-(AZA)INDOLSULFONAMIDES
Ledecq, Marie, Pegurier, Cécile, Provins, Laurent, Boshta, Nader, El-Tayeb, Ali, Rashed, Mahmoud, Mueller, Christa E, Cardenas, Alvaro, Hockemeyer, Joerg
Year of Publication 23.12.2022
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Year of Publication 23.12.2022
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