The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
Nag, Suman, Trivedi, Darshan V, Sarkar, Saswata S, Adhikari, Arjun S, Sunitha, Margaret S, Sutton, Shirley, Ruppel, Kathleen M, Spudich, James A
Published in Nature structural & molecular biology (01.06.2017)
Published in Nature structural & molecular biology (01.06.2017)
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Cryo-EM structure of the folded-back state of human β-cardiac myosin
Grinzato, Alessandro, Auguin, Daniel, Kikuti, Carlos, Nandwani, Neha, Moussaoui, Dihia, Pathak, Divya, Kandiah, Eaazhisai, Ruppel, Kathleen M., Spudich, James A., Houdusse, Anne, Robert-Paganin, Julien
Published in Nature communications (31.05.2023)
Published in Nature communications (31.05.2023)
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β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Nature communications (18.06.2019)
Published in Nature communications (18.06.2019)
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Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
Morck, Makenna M, Bhowmik, Debanjan, Pathak, Divya, Dawood, Aminah, Spudich, James, Ruppel, Kathleen M
Published in eLife (29.06.2022)
Published in eLife (29.06.2022)
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Climatic impacts on an Arctic lake since 1300 AD: a multi-proxy lake sediment reconstruction from Prins Karls Forland, Svalbard
Orme, L. C., Lind, E. M., Holm, T. M., Kjellman, S. E., Koinig, K. A., Hormes, A., Rosqvist, G. C., Ruppel, M., Divine, D. V., Husum, K., Miettinen, A., Isaksson, E.
Published in Journal of paleolimnology (01.03.2023)
Published in Journal of paleolimnology (01.03.2023)
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Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level
Liu, Chao, Kawana, Masataka, Song, Dan, Ruppel, Kathleen M., Spudich, James A.
Published in Nature structural & molecular biology (01.06.2018)
Published in Nature structural & molecular biology (01.06.2018)
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Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin
Adhikari, Arjun S., Kooiker, Kristina B., Sarkar, Saswata S., Liu, Chao, Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Cell reports (Cambridge) (13.12.2016)
Published in Cell reports (Cambridge) (13.12.2016)
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Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness
Gyimesi, Máté, Horváth, Ádám I., Túrós, Demeter, Suthar, Sharad Kumar, Pénzes, Máté, Kurdi, Csilla, Canon, Louise, Kikuti, Carlos, Ruppel, Kathleen M., Trivedi, Darshan V., Spudich, James A., Lőrincz, István, Rauscher, Anna Á., Kovács, Mihály, Pál, Endre, Komoly, Sámuel, Houdusse, Anne, Málnási-Csizmadia, András
Published in Cell (15.10.2020)
Published in Cell (15.10.2020)
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Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin
Spudich, James A, Aksel, Tural, Bartholomew, Sadie R, Nag, Suman, Kawana, Masataka, Yu, Elizabeth Choe, Sarkar, Saswata S, Sung, Jongmin, Sommese, Ruth F, Sutton, Shirley, Cho, Carol, Adhikari, Arjun S, Taylor, Rebecca, Liu, Chao, Trivedi, Darshan, Ruppel, Kathleen M
Published in Journal of experimental biology (01.01.2016)
Published in Journal of experimental biology (01.01.2016)
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Vaccination induces HIV broadly neutralizing antibody precursors in humans
Leggat, David J, Cohen, Kristen W, Willis, Jordan R, Fulp, William J, deCamp, Allan C, Kalyuzhniy, Oleksandr, Cottrell, Christopher A, Menis, Sergey, Finak, Greg, Ballweber-Fleming, Lamar, Srikanth, Abhinaya, Plyler, Jason R, Schiffner, Torben, Liguori, Alessia, Rahaman, Farhad, Lombardo, Angela, Philiponis, Vincent, Whaley, Rachael E, Seese, Aaron, Brand, Joshua, Ruppel, Alexis M, Hoyland, Wesley, Yates, Nicole L, Williams, LaTonya D, Greene, Kelli, Gao, Hongmei, Mahoney, Celia R, Corcoran, Martin M, Cagigi, Alberto, Taylor, Alison, Brown, David M, Ambrozak, David R, Sincomb, Troy, Hu, Xiaozhen, Tingle, Ryan, Georgeson, Erik, Eskandarzadeh, Saman, Alavi, Nushin, Lu, Danny, Mullen, Tina-Marie, Kubitz, Michael, Groschel, Bettina, Maenza, Janine, Kolokythas, Orpheus, Khati, Nadia, Bethony, Jeffrey, Crotty, Shane, Roederer, Mario, Karlsson Hedestam, Gunilla B, Tomaras, Georgia D, Montefiori, David, Diemert, David, Koup, Richard A, Laufer, Dagna S, McElrath, M Juliana, McDermott, Adrian B, Schief, William R
Published in Science (American Association for the Advancement of Science) (02.12.2022)
Published in Science (American Association for the Advancement of Science) (02.12.2022)
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Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin
Pan, Stephen, Sommese, Ruth F, Sallam, Karim I, Nag, Suman, Sutton, Shirley, Miller, Susan M, Spudich, James A, Ruppel, Kathleen M, Ashley, Euan A
Published in BMC medical genetics (26.10.2015)
Published in BMC medical genetics (26.10.2015)
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Myosin structure/function: a combined mutagenesis-crystallography approach
Ruppel, Kathleen M, Lorenz, Michael, Spudich, James A
Published in Current opinion in structural biology (01.04.1995)
Published in Current opinion in structural biology (01.04.1995)
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