Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach
Kuebler, Wolfgang M, Jordt, Sven-Eric, Liedtke, Wolfgang B
Published in American journal of physiology. Lung cellular and molecular physiology (01.06.2020)
Published in American journal of physiology. Lung cellular and molecular physiology (01.06.2020)
Get full text
Journal Article
Elementary Ca²⁺ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function
Sonkusare, Swapnil K., Bonev, Adrian D., Ledoux, Jonathan, Liedtke, Wolfgang, Kotlikoff, Michael I., Heppner, Thomas J., Hill-Eubanks, David C., Nelson, Mark T.
Published in Science (American Association for the Advancement of Science) (04.05.2012)
Published in Science (American Association for the Advancement of Science) (04.05.2012)
Get full text
Journal Article
Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis
O’Conor, Christopher J., Ramalingam, Sendhilnathan, Zelenski, Nicole A., Benefield, Halei C., Rigo, Isaura, Little, Dianne, Wu, Chia-Lung, Chen, Di, Liedtke, Wolfgang, McNulty, Amy L., Guilak, Farshid
Published in Scientific reports (08.07.2016)
Published in Scientific reports (08.07.2016)
Get full text
Journal Article
Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission
Yeo, Michele, Chen, Yong, Jiang, Changyu, Chen, Gang, Wang, Kaiyuan, Chandra, Sharat, Bortsov, Andrey, Lioudyno, Maria, Zeng, Qian, Wang, Peng, Wang, Zilong, Busciglio, Jorge, Ji, Ru-Rong, Liedtke, Wolfgang
Published in Nature communications (27.10.2021)
Published in Nature communications (27.10.2021)
Get full text
Journal Article
TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis
Ye, Li, Kleiner, Sandra, Wu, Jun, Sah, Rajan, Gupta, Rana K, Banks, Alexander S, Cohen, Paul, Khandekar, Melin J, Boström, Pontus, Mepani, Rina J, Laznik, Dina, Kamenecka, Theodore M, Song, Xinyi, Liedtke, Wolfgang, Mootha, Vamsi K, Puigserver, Pere, Griffin, Patrick R, Clapham, David E, Spiegelman, Bruce M
Published in Cell (28.09.2012)
Published in Cell (28.09.2012)
Get full text
Journal Article
Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain
Kanju, Patrick, Chen, Yong, Lee, Whasil, Yeo, Michele, Lee, Suk Hee, Romac, Joelle, Shahid, Rafiq, Fan, Ping, Gooden, David M., Simon, Sidney A., Spasojevic, Ivan, Mook, Robert A., Liddle, Rodger A., Guilak, Farshid, Liedtke, Wolfgang B.
Published in Scientific reports (01.06.2016)
Published in Scientific reports (01.06.2016)
Get full text
Journal Article
Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion
Zhang, Yang, Liang, Pengfei, Yang, Liheng, Shan, Ke Zoe, Feng, Liping, Chen, Yong, Liedtke, Wolfgang, Coyne, Carolyn B, Yang, Huanghe
Published in eLife (07.06.2022)
Published in eLife (07.06.2022)
Get full text
Journal Article
TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity
Seth, Ratanesh K., Das, Suvarthi, Dattaroy, Diptadip, Chandrashekaran, Varun, Alhasson, Firas, Michelotti, Gregory, Nagarkatti, Mitzi, Nagarkatti, Prakash, Diehl, Anna Mae, Bell, P. Darwin, Liedtke, Wolfgang, Chatterjee, Saurabh
Published in Free radical biology & medicine (01.01.2017)
Published in Free radical biology & medicine (01.01.2017)
Get full text
Journal Article
Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes
Dicks, Amanda R, Maksaev, Grigory I, Harissa, Zainab, Savadipour, Alireza, Tang, Ruhang, Steward, Nancy, Liedtke, Wolfgang, Nichols, Colin G, Wu, Chia-Lung, Guilak, Farshid
Published in eLife (22.02.2023)
Published in eLife (22.02.2023)
Get full text
Journal Article
TRPV4 channels augment macrophage activation and ventilator-induced lung injury
Hamanaka, Kazutoshi, Jian, Ming-Yuan, Townsley, Mary I, King, Judy A, Liedtke, Wolfgang, Weber, David S, Eyal, Fabien G, Clapp, Mary M, Parker, James C
Published in American journal of physiology. Lung cellular and molecular physiology (01.09.2010)
Published in American journal of physiology. Lung cellular and molecular physiology (01.09.2010)
Get full text
Journal Article
Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension
Yang, Xiao-Ru, Lin, Amanda H Y, Hughes, Jennifer M, Flavahan, Nicholas A, Cao, Yuan-Ning, Liedtke, Wolfgang, Sham, James S K
Published in American journal of physiology. Lung cellular and molecular physiology (15.03.2012)
Published in American journal of physiology. Lung cellular and molecular physiology (15.03.2012)
Get full text
Journal Article
Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion
Mannaa, Marwan, Markó, Lajos, Balogh, András, Vigolo, Emilia, N’diaye, Gabriele, Kaßmann, Mario, Michalick, Laura, Weichelt, Ulrike, Schmidt–Ott, Kai M., Liedtke, Wolfgang B., Huang, Yu, Müller, Dominik N., Kuebler, Wolfgang M., Gollasch, Maik
Published in Scientific reports (20.03.2018)
Published in Scientific reports (20.03.2018)
Get full text
Journal Article
Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference
Arredondo Zamarripa, David, Noguez Imm, Ramsés, Bautista Cortés, Ana María, Vázquez Ruíz, Osvaldo, Bernardini, Michela, Fiorio Pla, Alessandra, Gkika, Dimitra, Prevarskaya, Natalia, López-Casillas, Fernando, Liedtke, Wolfgang, Clapp, Carmen, Thébault, Stéphanie
Published in Scientific reports (12.10.2017)
Published in Scientific reports (12.10.2017)
Get full text
Journal Article
Trpv4 Mediates Hypotonic Inhibition of Central Osmosensory Neurons via Taurine Gliotransmission
Ciura, Sorana, Prager-Khoutorsky, Masha, Thirouin, Zahra S., Wyrosdic, Joshua C., Olson, James E., Liedtke, Wolfgang, Bourque, Charles W.
Published in Cell reports (Cambridge) (22.05.2018)
Published in Cell reports (Cambridge) (22.05.2018)
Get full text
Journal Article
TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs
Hamanaka, Kazutoshi, Jian, Ming-Yuan, Weber, David S, Alvarez, Diego F, Townsley, Mary I, Al-Mehdi, Abu B, King, Judy A, Liedtke, Wolfgang, Parker, James C
Published in American journal of physiology. Lung cellular and molecular physiology (01.10.2007)
Published in American journal of physiology. Lung cellular and molecular physiology (01.10.2007)
Get full text
Journal Article
Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss
Cohen, Paul, Miyazaki, Makoto, Socci, Nicholas D., Hagge-Greenberg, Aaron, Liedtke, Wolfgang, Soukas, Alexander A., Sharma, Ratnendra, Hudgins, Lisa C., Ntambi, James M., Friedman, Jeffrey M.
Published in Science (American Association for the Advancement of Science) (12.07.2002)
Published in Science (American Association for the Advancement of Science) (12.07.2002)
Get full text
Journal Article
Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor
Liedtke, Wolfgang, Choe, Yong, Martí-Renom, Marc A., Bell, Andrea M., Denis, Charlotte S., AndrejŠali, Hudspeth, A.J., Friedman, Jeffrey M., Heller, Stefan
Published in Cell (27.10.2000)
Published in Cell (27.10.2000)
Get full text
Journal Article