T-CAST: An optimized CAST-Seq pipeline for TALEN confirms superior safety and efficacy of obligate-heterodimeric scaffolds
Rhiel, Manuel, Geiger, Kerstin, Andrieux, Geoffroy, Rositzka, Julia, Boerries, Melanie, Cathomen, Toni, Cornu, Tatjana I
Published in Frontiers in genome editing (20.02.2023)
Published in Frontiers in genome editing (20.02.2023)
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Journal Article
Unexpected failure rates for modular assembly of engineered zinc fingers
Joung, J Keith, Ramirez, Cherie L, Foley, Jonathan E, Wright, David A, Müller-Lerch, Felix, Rahman, Shamim H, Cornu, Tatjana I, Winfrey, Ronnie J, Sander, Jeffry D, Fu, Fengli, Townsend, Jeffrey A, Cathomen, Toni, Voytas, Daniel F
Published in Nature methods (01.05.2008)
Published in Nature methods (01.05.2008)
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Journal Article
CRISPR-Cas12a for Highly Efficient and Marker-Free Targeted Integration in Human Pluripotent Stem Cells
Hammad, Ruba, Alzubi, Jamal, Rhiel, Manuel, Chmielewski, Kay O, Mosti, Laura, Rositzka, Julia, Heugel, Marcel, Lawrenz, Jan, Pennucci, Valentina, Gläser, Birgitta, Fischer, Judith, Schambach, Axel, Moritz, Thomas, Lachmann, Nico, Cornu, Tatjana I, Mussolino, Claudio, Schäfer, Richard, Cathomen, Toni
Published in International journal of molecular sciences (01.01.2024)
Published in International journal of molecular sciences (01.01.2024)
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Journal Article
Automated generation of gene-edited CAR T cells at clinical scale
Alzubi, Jamal, Lock, Dominik, Rhiel, Manuel, Schmitz, Sabrina, Wild, Stefan, Mussolino, Claudio, Hildenbeutel, Markus, Brandes, Caroline, Rositzka, Julia, Lennartz, Simon, Haas, Simone A., Chmielewski, Kay O., Schaser, Thomas, Kaiser, Andrew, Cathomen, Toni, Cornu, Tatjana I.
Published in Molecular therapy. Methods & clinical development (12.03.2021)
Published in Molecular therapy. Methods & clinical development (12.03.2021)
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Journal Article
Cell-Based Models of 'Cytokine Release Syndrome' Endorse CD40L and Granulocyte-Macrophage Colony-Stimulating Factor Knockout in Chimeric Antigen Receptor T Cells as Mitigation Strategy
Dibas, Ala, Rhiel, Manuel, Patel, Vidisha Bhavesh, Andrieux, Geoffroy, Boerries, Melanie, Cornu, Tatjana I, Alzubi, Jamal, Cathomen, Toni
Published in Cells (Basel, Switzerland) (01.11.2023)
Published in Cells (Basel, Switzerland) (01.11.2023)
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Journal Article
Allele-Specific Disruption of a Common STAT3 Autosomal Dominant Allele Is Not Sufficient to Restore Downstream Signaling in Patient-Derived T Cells
König, Saskia, Fliegauf, Manfred, Rhiel, Manuel, Grimbacher, Bodo, Cornu, Tatjana I., Cathomen, Toni, Mussolino, Claudio
Published in Genes (20.10.2022)
Published in Genes (20.10.2022)
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Journal Article
Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq
Turchiano, Giandomenico, Andrieux, Geoffroy, Klermund, Julia, Blattner, Georges, Pennucci, Valentina, el Gaz, Melina, Monaco, Gianni, Poddar, Sushmita, Mussolino, Claudio, Cornu, Tatjana I., Boerries, Melanie, Cathomen, Toni
Published in Cell stem cell (03.06.2021)
Published in Cell stem cell (03.06.2021)
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Journal Article
On- and off-target effects of paired CRISPR-Cas nickase in primary human cells
Klermund, Julia, Rhiel, Manuel, Kocher, Thomas, Chmielewski, Kay Ole, Bischof, Johannes, Andrieux, Geoffroy, el Gaz, Melina, Hainzl, Stefan, Boerries, Melanie, Cornu, Tatjana I., Koller, Ulrich, Cathomen, Toni
Published in Molecular therapy (01.05.2024)
Published in Molecular therapy (01.05.2024)
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Journal Article
HIV Gene Therapy: An Update
Cornu, Tatjana I, Mussolino, Claudio, Müller, Matthias C, Wehr, Claudia, Kern, Winfried V, Cathomen, Toni
Published in Human gene therapy (01.01.2021)
Published in Human gene therapy (01.01.2021)
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Journal Article
Cells Expressing the RING Finger Z Protein Are Resistant to Arenavirus Infection
CORNU, Tatiana I, FELDMANN, Heinz, DE LA TORRE, Juan Carlos
Published in Journal of Virology (01.03.2004)
Published in Journal of Virology (01.03.2004)
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Journal Article
Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing
Knipping, Friederike, Newby, Gregory A., Eide, Cindy R., McElroy, Amber N., Nielsen, Sarah C., Smith, Kyle, Fang, Yongxing, Cornu, Tatjana I., Costa, Caroline, Gutierrez-Guerrero, Alejandra, Bingea, Samuel P., Feser, Colby J., Steinbeck, Benjamin, Hippen, Keli L., Blazar, Bruce R., McCaffrey, Anton, Mussolino, Claudio, Verhoeyen, Els, Tolar, Jakub, Liu, David R., Osborn, Mark J.
Published in Molecular therapy (05.01.2022)
Published in Molecular therapy (05.01.2022)
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Journal Article
Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors
Händel, Eva-Maria, Gellhaus, Katharina, Khan, Kafaitullah, Bednarski, Christien, Cornu, Tatjana I, Müller-Lerch, Felix, Kotin, Robert M, Heilbronn, Regine, Cathomen, Toni
Published in Human gene therapy (01.03.2012)
Published in Human gene therapy (01.03.2012)
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