Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy
Trotter, B. Wesley, Nanda, Kausik K., Burgey, Christopher S., Potteiger, Craig M., Deng, James Z., Green, Ahren I., Hartnett, John C., Kett, Nathan R., Wu, Zhicai, Henze, Darrell A., Penna, Kimberly Della, Desai, Reshma, Leitl, Michael D., Lemaire, Wei, White, Rebecca B., Yeh, Suzie, Urban, Mark O., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors
Greshock, Thomas J., Sanders, John M., Drolet, Robert E., Rajapakse, Hemaka A., Chang, Ronald K., Kim, Boyoung, Rada, Vanessa L., Tiscia, Heather E., Su, Hua, Lai, Ming-Tain, Sur, Sylvie M., Sanchez, Rosa I., Bilodeau, Mark T., Renger, John J., Kern, Jonathan T., McCauley, John A.
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
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Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics
Wolkenberg, Scott E., Nolt, M. Brad, Bilodeau, Mark T., Trotter, B. Wesley, Manley, Peter J., Kett, Nathan R., Nanda, Kausik K., Wu, Zhicai, Cato, Matthew J., Kane, Stefanie A., Kiss, Laszlo, Spencer, Robert H., Wang, Jixin, Lynch, Joseph J., Regan, Christopher P., Stump, Gary L., Li, Bing, White, Rebecca, Yeh, Suzie, Dinsmore, Christopher J., Lindsley, Craig W., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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Benzimidazole CB2 agonists: Design, synthesis and SAR
Nanda, Kausik K., Henze, Darrell A., Della Penna, Kimberly, Desai, Reshma, Leitl, Michael, Lemaire, Wei, White, Rebecca B., Yeh, Suzie, Brouillette, Janine N., Hartman, George D., Bilodeau, Mark T., Trotter, B. Wesley
Published in Bioorganic & medicinal chemistry letters (15.02.2014)
Published in Bioorganic & medicinal chemistry letters (15.02.2014)
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Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model
Bilodeau, Mark T., Balitza, Adrienne E., Hoffman, Jacob M., Manley, Peter J., Barnett, Stanley F., Defeo-Jones, Deborah, Haskell, Kathleen, Jones, Raymond E., Leander, Karen, Robinson, Ronald G., Smith, Anthony M., Huber, Hans E., Hartman, George D.
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Fused heterocyclic M₁ positive allosteric modulators
Kuduk, Scott D, Di Marco, Christina N, Cofre, Victoria, Ray, William J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Hartman, George D, Bilodeau, Mark T
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
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Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series
Kuduk, Scott D., Chang, Ronald K., Di Marco, Christina N., Ray, William J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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N-Heterocyclic derived M1 positive allosteric modulators
KUDUK, Scott D, DI MARCO, Christina N, THOMPSON, Charles D, HARTMAN, George D, BILODEAU, Mark T, COFRE, Victoria, PITTS, Daniel R, RAY, William J, LEI MA, WITTMANN, Marion, VENG, Lone, SEAGER, Matthew A, KOEPLINGER, Kenneth
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
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Rapid assembly of diverse and potent allosteric Akt inhibitors
Wu, Zhicai, Robinson, Ronald G., Fu, Sheng, Barnett, Stanley F., Defeo-Jones, Deborah, Jones, Raymond E., Kral, Astrid M., Huber, Hans E., Kohl, Nancy E., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3)
Kuduk, Scott D., Di Marco, Christina N., Chang, Ronald K., DiPardo, Robert M., Cook, Sean P., Cato, Matthew J., Jovanovska, Aneta, Urban, Mark O., Leitl, Michael, Spencer, Robert H., Kane, Stefanie A., Bilodeau, Mark T., Hartman, George D., Bock, Mark G.
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
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Tricyclic imidazole antagonists of the Neuropeptide S Receptor
Trotter, B. Wesley, Nanda, Kausik K., Manley, Peter J., Uebele, Victor N., Condra, Cindra L., Gotter, Anthony L., Menzel, Karsten, Henault, Martin, Stocco, Rino, Renger, John J., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Pyridine containing M1 positive allosteric modulators with reduced plasma protein binding
KUDUK, Scott D, DI MARCO, Christina N, HARTMAN, George D, BILODEAU, Mark T, COFRE, Victoria, PITTS, Daniel R, RAY, William J, LEI MA, WITTMANN, Marion, SEAGER, Matthew, KOEPLINGER, Kenneth, THOMPSON, Chuck D
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Heterocyclic fused pyridone carboxylic acid M1 positive allosteric modulators
KUDUK, Scott D, DI MARCO, Christina N, BILODEAU, Mark T, CHANG, Ronald K, RAY, William J, LEI MA, WITTMANN, Marion, SEAGER, Matthew A, KOEPLINGER, Kenneth A, THOMPSON, Charles D, HARTMAN, George D
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3)
Kuduk, Scott D., Chang, Ronald K., Di Marco, Christina N., DiPardo, Robert M., Cook, Sean P., Cato, Matthew J., Jovanovska, Aneta, Urban, Mark O., Leitl, Michael, Spencer, Robert H., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
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Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on in vivo efficacy in a rodent model of analgesia
Manley, Peter J., Zartman, Amy, Paone, Daniel V., Burgey, Christopher S., Henze, Darrell A., Penna, Kimberly Della, Desai, Reshma, Leitl, Michael D., Lemaire, Wei, White, Rebecca B., Yeh, Suzie, Urban, Mark O., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T., Trotter, B. Wesley
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Hydroxy cycloalkyl fused pyridone carboxylic acid M1, positive allosteric modulators
KUDUK, Scott D, DIPARDO, Robert M, BILODEAU, Mark T, BESHORE, Douglas C, RAY, William J, LEI MA, WITTMANN, Marion, SEAGER, Matthew A, KOEPLINGER, Kenneth A, THOMPSON, Charles D, HARTMAN, George D
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists
Melamed, Jeffrey Y., Zartman, Amy E., Kett, Nathan R., Gotter, Anthony L., Uebele, Victor N., Reiss, Duane R., Condra, Cindra L., Fandozzi, Christine, Lubbers, Laura S., Rowe, Blake A., McGaughey, Georgia B., Henault, Martin, Stocco, Rino, Renger, John J., Hartman, George D., Bilodeau, Mark T., Trotter, B. Wesley
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors
Hartnett, John C., Barnett, Stanley F., Bilodeau, Mark T., Defeo-Jones, Deborah, Hartman, George D., Huber, Hans E., Jones, Raymond E., Kral, Astrid M., Robinson, Ronald G., Wu, Zhicai
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors
Wu, Zhicai, Hartnett, John C., Neilson, Lou Anne, Robinson, Ronald G., Fu, Sheng, Barnett, Stanley F., Defeo-Jones, Deborah, Jones, Raymond E., Kral, Astrid M., Huber, Hans E., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry (15.02.2008)
Published in Bioorganic & medicinal chemistry (15.02.2008)
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Optimization of a pyrazolo[1,5- a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics
Fraley, Mark E., Rubino, Robert S., Hoffman, William F., Hambaugh, Scott R., Arrington, Kenneth L., Hungate, Randall W., Bilodeau, Mark T., Tebben, Andrew J., Rutledge, Ruth Z., Kendall, Richard L., McFall, Rosemary C., Huckle, William R., Coll, Kathleen E., Thomas, Kenneth A.
Published in Bioorganic & medicinal chemistry letters (16.12.2002)
Published in Bioorganic & medicinal chemistry letters (16.12.2002)
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