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Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2011)
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Published in PloS one (18.02.2014)
Published in PloS one (18.02.2014)
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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)
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Published in Bioorganic & medicinal chemistry letters (01.06.2019)
Published in Bioorganic & medicinal chemistry letters (01.06.2019)
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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety
He, Shuwen, Lai, Zhong, Hong, Qingmei, Shang, Jackie, Reibarkh, Mikhail, Kuethe, Jeffrey T., Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Cernak, Timothy A., Dykstra, Kevin D., Sperbeck, Donald M., Wu, Zhicai, Yu, Yang, Yang, Ginger X., Jian, Tianying, Verras, Andreas, Sonatore, Lisa M., Wiltsie, Judyann, Chung, Christine C., Murphy, Beth A., Gorski, Judith N., Liu, Jinqi, Xiao, Jianying, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., Pinto, Shirly, Nargund, Ravi P., DeVita, Robert J.
Published in Bioorganic & medicinal chemistry letters (15.05.2019)
Published in Bioorganic & medicinal chemistry letters (15.05.2019)
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Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes
Shah, Shrenik K, He, Shuwen, Guo, Liangqin, Truong, Quang, Qi, Hongbo, Du, Wu, Lai, Zhong, Liu, Jian, Jian, Tianying, Hong, Qingmei, Dobbelaar, Peter, Ye, Zhixiong, Sherer, Edward, Feng, Zhe, Yu, Yang, Wong, Frederick, Samuel, Koppara, Madiera, Maria, Karanam, Bindhu V, Reddy, Vijay B, Mitelman, Stan, Tong, Sharon X, Chicchi, Gary G, Tsao, Kwei-Lan, Trusca, Dorina, Feng, Yue, Wu, Margaret, Shao, Qing, Trujillo, Maria E, Eiermann, George J, Li, Cai, Pachanski, Michele, Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Morissette, Pierre, Volksdorf, Sylvia, Kerr, Janet, Zhang, Bei B, Howard, Andrew D, Zhou, Yun-Ping, Pasternak, Alexander, Nargund, Ravi P, Hagmann, William K
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain
Hoyt, Scott B., London, Clare, Abbadie, Catherine, Felix, John P., Garcia, Maria L., Jochnowitz, Nina, Karanam, Bindhu V., Li, Xiaohua, Lyons, Kathryn A., McGowan, Erin, Priest, Birgit T., Smith, McHardy M., Warren, Vivien A., Thomas-Fowlkes, Brande S., Kaczorowski, Gregory J., Duffy, Joseph L.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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Energy absorption and propagation in laser-created sparks
Bindhu, C V, Harilal, S S, Tillack, M S, Najmabadi, F, Gaeris, A C
Published in Applied spectroscopy (01.06.2004)
Published in Applied spectroscopy (01.06.2004)
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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety
He, Shuwen, Hong, Qingmei, Lai, Zhong, Yang, David X, Ting, Pauline C, Kuethe, Jeffrey T, Cernak, Timothy A, Dykstra, Kevin D, Sperbeck, Donald M, Wu, Zhicai, Yu, Yang, Yang, Ginger X, Jian, Tianying, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D, Sonatore, Lisa M, Wiltsie, Judyann, Liu, Jinqi, Gorski, Judith N, Chung, Christine C, Gibson, Jack T, Lisnock, JeanMarie, Xiao, Jianying, Wolff, Michael, Tong, Sharon X, Madeira, Maria, Karanam, Bindhu V, Shen, Dong-Ming, Balkovec, James M, Pinto, Shirly, Nargund, Ravi P, DeVita, Robert J
Published in ACS medicinal chemistry letters (09.10.2014)
Published in ACS medicinal chemistry letters (09.10.2014)
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Benzazepinone Nav1.7 blockers : Potential treatments for neuropathic pain
HOYT, Scott B, LONDON, Clare, KARANAM, Bindhu V, XIAOHUA LI, LYONS, Kathryn A, MCGOWAN, Erin, EUAN MACINTYRE, D, MARTIN, William J, PRIEST, Birgit T, SMITH, Mchardy M, TSCHIRRET-GUTH, Richard, WARREN, Vivien A, OK, Hyun, WILLIAMS, Brande S, KACZOROWSKI, Gregory J, PARSONS, William H, GONZALEZ, Edward, DUFFY, Joseph L, ABBADIE, Catherine, DEAN, Brian, FELIX, John P, GARCIA, Maria L, JOCHNOWITZ, Nina
Published in Bioorganic & medicinal chemistry letters (15.11.2007)
Published in Bioorganic & medicinal chemistry letters (15.11.2007)
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Imidazopyridines : A novel class of hNav1.7 channel blockers
LONDON, Clare, HOYT, Scott B, LYONS, Kathryn A, XIAOHUA LI, KARANAM, Bindhu V, JOCHNOWITZ, Nina, GARCIA, Maria L, FELIX, John P, DEAN, Brian, ABBADIE, Catherine, KACZOROWSKI, Gregory J, DUFFY, Joseph L, PARSONS, William H, WILLIAMS, Brande S, WARREN, Vivien A, TSCHIRRET-GUTH, Richard, SMITH, Mchardy M, PRIEST, Birgit T, MCGOWAN, Erin, MARTIN, William J
Published in Bioorganic & medicinal chemistry letters (01.03.2008)
Published in Bioorganic & medicinal chemistry letters (01.03.2008)
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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety
He, Shuwen, Hong, Qingmei, Lai, Zhong, Wu, Zhicai, Yu, Yang, Kim, David W, Ting, Pauline C, Kuethe, Jeffrey T, Yang, Ginger X, Jian, Tianying, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D, Sperbeck, Donald M, Sonatore, Lisa M, Wiltsie, Judyann, Chung, Christine C, Gibson, Jack T, Lisnock, JeanMarie, Murphy, Beth A, Gorski, Judith N, Liu, Jinqi, Chen, Dunlu, Chen, Xiaoli, Wolff, Michael, Tong, Sharon X, Madeira, Maria, Karanam, Bindhu V, Shen, Dong-Ming, Balkovec, James M, Pinto, Shirly, Nargund, Ravi P, DeVita, Robert J
Published in ACS medicinal chemistry letters (08.08.2013)
Published in ACS medicinal chemistry letters (08.08.2013)
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Mechanistic Studies on the Metabolic Scission of Thiazolidinedione Derivatives to Acyclic Thiols
Reddy, Vijay Bhasker G, Karanam, Bindhu V, Gruber, Wendy L, Wallace, Michael A, Vincent, Stella H, Franklin, Ronald B, Baillie, Thomas A
Published in Chemical research in toxicology (01.05.2005)
Published in Chemical research in toxicology (01.05.2005)
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SPECIES DIFFERENTIAL STEREOSELECTIVE OXIDATION OF A METHYLSULFIDE METABOLITE OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL)PHENYL]METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DUAL AGONIST
KARANAM, Bindhu V, WELCH, Christopher J, REDDY, Vijay G, CHILENSKI, Jennifer, BIBA, Mirlinda, VINCENT, Stella
Published in Drug metabolism and disposition (01.10.2004)
Published in Drug metabolism and disposition (01.10.2004)
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Discovery of imidazole carboxamides as potent and selective CCK1R agonists
Zhu, Cheng, Hansen, Alexa R., Bateman, Thomas, Chen, Zhesheng, Holt, Tom G., Hubert, James A., Karanam, Bindhu V., Lee, Susan J., Pan, Jie, Qian, Su, Reddy, Vijay B.G., Reitman, Marc L., Strack, Alison M., Tong, Vincent, Weingarth, Drew T., Wolff, Michael S., MacNeil, Doug J., Weber, Ann E., Duffy, Joseph L., Edmondson, Scott D.
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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In vitro metabolism of MK-0767 [(±)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phe nyl] methyl]benzamide], a peroxisome proliferator-activated receptor α/γ agonist. II. Identification of metabolites by liquid chromatography-tandem mass spectrometry
LIU, David Q, KARANAM, Bindhu V, DOSS, George A, SIDLER, Rick R, VINCENT, Stella H, HOP, Cornelis E. C. A
Published in Drug metabolism and disposition (01.09.2004)
Published in Drug metabolism and disposition (01.09.2004)
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Journal Article
IDENTIFICATION AND METABOLISM OF A NOVEL DIHYDROHYDROXY-S-GLUTATHIONYL CONJUGATE OF A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONIST, MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL) PHENYL]METHYL]BENZAMIDE], IN RATS
REDDY, Vijay Bhasker G, DOSS, George A, CREIGHTON, Mellissa, KOCHANSKY, Christopher J, VINCENT, Stella H, FRANKLIN, Ronald B, KARANAM, Bindhu V
Published in Drug metabolism and disposition (01.10.2004)
Published in Drug metabolism and disposition (01.10.2004)
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Journal Article
In vitro metabolism of MK-0767 [(±)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor α/γ agonist. I. Role of cytochrome P450, methyltransferases, flavin monooxygenases, and esterases
KARANAM, Bindhu V, HOP, Cornelis E. C. A, LIU, David Q, WALLACE, Mike, DEAN, Dennis, SATOH, Hiroya, KOMURO, Masakatsu, AWANO, Katsuya, VINCENT, Stella H
Published in Drug metabolism and disposition (01.09.2004)
Published in Drug metabolism and disposition (01.09.2004)
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