Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
Spradlin, Jessica N., Hu, Xirui, Ward, Carl C., Brittain, Scott M., Jones, Michael D., Ou, Lisha, To, Milton, Proudfoot, Andrew, Ornelas, Elizabeth, Woldegiorgis, Mikias, Olzmann, James A., Bussiere, Dirksen E., Thomas, Jason R., Tallarico, John A., McKenna, Jeffrey M., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.
Published in Nature chemical biology (01.07.2019)
Published in Nature chemical biology (01.07.2019)
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Bardoxolone conjugation enables targeted protein degradation of BRD4
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Published in Scientific reports (23.09.2020)
Published in Scientific reports (23.09.2020)
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Isobe, Yosuke, Okumura, Mikiko, McGregor, Lynn M., Brittain, Scott M., Jones, Michael D., Liang, Xiaoyou, White, Ross, Forrester, William, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.
Published in Nature chemical biology (01.11.2020)
Published in Nature chemical biology (01.11.2020)
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Deubiquitinase-targeting chimeras for targeted protein stabilization
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Published in Nature chemical biology (01.04.2022)
Published in Nature chemical biology (01.04.2022)
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Oxidative cyclization reagents reveal tryptophan cation–π interactions
Xie, Xiao, Moon, Patrick J., Crossley, Steven W. M., Bischoff, Amanda J., He, Dan, Li, Gen, Dao, Nam, Gonzalez-Valero, Angel, Reeves, Audrey G., McKenna, Jeffrey M., Elledge, Susanna K., Wells, James A., Toste, F. Dean, Chang, Christopher J.
Published in Nature (London) (21.03.2024)
Published in Nature (London) (21.03.2024)
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Rational Chemical Design of Molecular Glue Degraders
Toriki, Ethan S., Papatzimas, James W., Nishikawa, Kaila, Dovala, Dustin, Frank, Andreas O., Hesse, Matthew J., Dankova, Daniela, Song, Jae-Geun, Bruce-Smythe, Megan, Struble, Heidi, Garcia, Francisco J., Brittain, Scott M., Kile, Andrew C., McGregor, Lynn M., McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.
Published in ACS central science (24.05.2023)
Published in ACS central science (24.05.2023)
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Correction to “Rational Chemical Design of Molecular Glue Degraders”
Toriki, Ethan S., Papatzimas, James W., Nishikawa, Kaila, Dovala, Dustin, Frank, Andreas O., Hesse, Matthew J., Dankova, Daniela, Song, Jae-Geun, Bruce-Smythe, Megan, Struble, Heidi, Garcia, Francisco J., Brittain, Scott M., Kile, Andrew C., McGregor, Lynn M., McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.
Published in ACS central science (23.08.2023)
Published in ACS central science (23.08.2023)
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Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications
Henning, Nathaniel J, Manford, Andrew G, Spradlin, Jessica N, Brittain, Scott M, Mckenna, Jeffrey M, Tallarico, John A, Schirle, Markus, Rape, Michael, Nomura, Daniel K
Published in bioRxiv (15.04.2021)
Published in bioRxiv (15.04.2021)
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Targeted Protein Degradation through E2 Recruitment
te, Nafsika, Dovala, Dustin, Hesse, Matthew J, Mckenna, Jeffrey M, Tallarico, John A, Schirle, Markus, Nomura, Daniel K
Published in bioRxiv (20.12.2022)
Published in bioRxiv (20.12.2022)
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Moncure, David, John Del Piero, McKenna, Jeffrey
Published in Inside Counsel. Breaking News (23.11.2016)
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Published in Inside Counsel. Breaking News (23.11.2016)
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Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors
Moon, Patrick, Boike, Lydia, Dovala, Dustin, Henning, Nathaniel J, Knapp, Mark, Spradlin, Jessica N, Ward, Carl C, Wolleb, Helen, Zammit, Charlotte M, Fuller, Daniel, Blake, Gabrielle, Murphy, Jason P, Wang, Feng, Lu, Yipin, Moquin, Stephanie A, Tandeske, Laura, Hesse, Matthew J, Mckenna, Jeffrey M, Tallarico, John, Schirle, Markus, Toste, F Dean, Nomura, Daniel K
Published in bioRxiv (07.03.2022)
Published in bioRxiv (07.03.2022)
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Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53 to Impair Breast Cancer Pathogenicity
Isobe, Yosuke, Okumura, Mikiko, White, Ross, Mcgregor, Lynn M, Mckenna, Jeffrey M, Tallarico, John A, Schirle, Markus, Maimone, Thomas J, Nomura, Daniel K
Published in bioRxiv (22.10.2019)
Published in bioRxiv (22.10.2019)
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A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL
Tong, Bingqi, Spradlin, Jessica N, Novaes, Luiz Ft, Zhang, Erika, Hu, Xirui, Moeller, Malte, Brittain, Scott M, Mcgregor, Lynn M, Mckenna, Jeffrey M, Tallarico, John A, Schirle, Markus, Maimone, Thomas J, Nomura, Daniel K
Published in bioRxiv (03.04.2020)
Published in bioRxiv (03.04.2020)
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Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications
Ward, Carl C, Kleinman, Jordan I, Clive Yik Sham Chung, Kim, Kenneth, Petri, Yana, Lee, Patrick S, Thomas, Jason R, Tallarico, John A, Mckenna, Jeffrey M, Schirle, Markus, Nomura, Daniel K
Published in bioRxiv (16.10.2018)
Published in bioRxiv (16.10.2018)
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Paper
Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation
Spradlin, Jessica N, Hu, Xirui, Ward, Carl C, Brittain, Scott M, Jones, Michael D, Ou, Lisha, To, Milton, Proudfoot, Andrew, Ornleas, Elizabeth, Woldegiorgis, Mikias, Olzmann, James A, Bussiere, Dirksen E, Thomas, Jason R, Tallarico, John A, Mckenna, Jeffrey M, Schirle, Markus, Maimone, Thomas J, Nomura, Daniel K
Published in bioRxiv (09.04.2019)
Published in bioRxiv (09.04.2019)
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