Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality
Beauparlant, David, Rusert, Peter, Magnus, Carsten, Kadelka, Claus, Weber, Jacqueline, Uhr, Therese, Zagordi, Osvaldo, Oberle, Corinna, Duenas-Decamp, Maria J, Clapham, Paul R, Metzner, Karin J, Günthard, Huldrych F, Trkola, Alexandra
Published in PLoS pathogens (06.03.2017)
Published in PLoS pathogens (06.03.2017)
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Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue
Gonzalez-Perez, Maria Paz, O'Connell, Olivia, Lin, Rongheng, Sullivan, W Matthew, Bell, Jeanne, Simmonds, Peter, Clapham, Paul R
Published in Retrovirology (15.03.2012)
Published in Retrovirology (15.03.2012)
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Genotypic and functional properties of early infant HIV-1 envelopes
Kishko, Michael, Somasundaran, Mohan, Brewster, Frank, Sullivan, John L, Clapham, Paul R, Luzuriaga, Katherine
Published in Retrovirology (15.08.2011)
Published in Retrovirology (15.08.2011)
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No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications
Quitadamo, Briana, Peters, Paul J., Koch, Matthew, Luzuriaga, Katherine, Cheng-Mayer, Cecilia, Clapham, Paul R., Gonzalez-Perez, Maria Paz
Published in Archives of virology (01.02.2019)
Published in Archives of virology (01.02.2019)
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Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages
Shen, Ruizhong, Meng, Gang, Ochsenbauer, Christina, Clapham, Paul R, Grams, Jayleen, Novak, Lea, Kappes, John C, Smythies, Lesley E, Smith, Phillip D
Published in PLoS pathogens (01.05.2011)
Published in PLoS pathogens (01.05.2011)
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HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages
Musich, Thomas, O'Connell, Olivia, Gonzalez-Perez, Maria Paz, Derdeyn, Cynthia A, Peters, Paul J, Clapham, Paul R
Published in Retrovirology (14.03.2015)
Published in Retrovirology (14.03.2015)
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Potent Inhibition of HIV-1 Infectivity in Macrophages and Lymphocytes by a Novel CCR5 Antagonist
Simmons, Graham, Clapham, Paul R., Picard, Laurent, Offord, Robin E., Rosenkilde, Mette M., Schwartz, Thue W., Buser, Raphaële, Timothy N. C. Wells, Amanda E. I. Proudfoot
Published in Science (American Association for the Advancement of Science) (11.04.1997)
Published in Science (American Association for the Advancement of Science) (11.04.1997)
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Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes
Peters, Paul J, Gonzalez-Perez, Maria Paz, Musich, Thomas, Moore Simas, Tiffany A, Lin, Rongheng, Morse, Abraham N, Shattock, Robin J, Derdeyn, Cynthia A, Clapham, Paul R
Published in Retrovirology (09.06.2015)
Published in Retrovirology (09.06.2015)
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A Broad-Spectrum Chemokine Antagonist Encoded by Kaposi's Sarcoma- Associated Herpesvirus
Kledal, Thomas N., Rosenkilde, Mette M., Coulin, Florence, Simmons, Graham, Johnsen, Anders H., Alouani, Sami, Power, Christine A., Lüttichau, Hans R., Gerstoft, Jan, Clapham, Paul R., Clark-Lewis, Ian, Timothy N. C. Wells, Schwartz, Thue W.
Published in Science (American Association for the Advancement of Science) (12.09.1997)
Published in Science (American Association for the Advancement of Science) (12.09.1997)
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Stromal Down-Regulation of Macrophage CD4/CCR5 Expression and NF-[kappa]B Activation Mediates HIV-1 Non-Permissiveness in Intestinal Macrophages
Shen, Ruizhong, Meng, Gang, Ochsenbauer, Christina, Clapham, Paul R, Grams, Jayleen, Novak, Lea, Kappes, John C, Smythies, Lesley E, Smith, Phillip D
Published in PLoS pathogens (01.05.2011)
Published in PLoS pathogens (01.05.2011)
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Journal Article
Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis
Duenas-Decamp, Maria José, Peters, Paul J, Repik, Alexander, Musich, Thomas, Gonzalez-Perez, Maria Paz, Caron, Catherine, Brown, Richard, Ball, Jonathan, Clapham, Paul R
Published in Future virology (01.07.2010)
Published in Future virology (01.07.2010)
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Journal Article
HIV-1 tropism and co-receptor use
Dittmar, Matthias T, McKnight, Áine, Simmons, Graham, Clapham, Paul R, Weiss, Robin A, Simmonds, Peter
Published in Nature (London) (06.02.1997)
Published in Nature (London) (06.02.1997)
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Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells
Clapham, P R, Weber, J N, Whitby, D, McIntosh, K, Dalgleish, A G, Maddon, P J, Deen, K C, Sweet, R W, Weiss, R A
Published in Nature (London) (26.01.1989)
Published in Nature (London) (26.01.1989)
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